(Q34730572)

4 August 2017

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title

Tau function and dysfunction in neurons: its role in neurodegenerative disorders (English)

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4 August 2017

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Jesús Avila

1

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4 August 2017

Filip Lim

2

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4 August 2017

Francisco Moreno

3

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4 August 2017

Carlos Belmonte

4

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4 August 2017

A Claudio Cuello

5

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4 August 2017

1 June 2002

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4 August 2017

Molecular Neurobiology

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4 August 2017

25

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4 August 2017

3

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4 August 2017

213-231

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https://scigraph.springernature.com/pub.10.1385/mn:25:3:213

4 August 2017

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cites work

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

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12 December 2020

In vitro conditions for the self-polymerization of the microtubule-associated protein, tau factor

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12 December 2020

Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain.

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12 December 2020

Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies

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12 December 2020

The FTDP-17-linked mutation R406W abolishes the interaction of phosphorylated tau with microtubules

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12 December 2020

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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12 December 2020

Activation of m1 muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells

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12 December 2020

Tau protein pathology in neurodegenerative diseases.

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12 December 2020

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

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12 December 2020

Analysis of microtubule-associated protein tau glycation in paired helical filaments.

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12 December 2020

Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau.

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12 December 2020

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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12 December 2020

Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

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12 December 2020

Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAPP751)

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12 December 2020

Tau protein and the establishment of an axonal morphology

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12 December 2020

Degradation of tau by lysosomal enzyme cathepsin D: implication for Alzheimer neurofibrillary degeneration.

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12 December 2020

Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors

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12 December 2020

Tau protein function in living cells

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12 December 2020

Immature and mature variants of MAP2 and tau proteins and neuronal plasticity

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12 December 2020

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

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12 December 2020

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly

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12 December 2020

High molecular weight microtubule-associated proteins: purification by electro-elution and amino acid compositions

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12 December 2020

Structure and novel exons of the human tau gene

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12 December 2020

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2.

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12 December 2020

Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations

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12 December 2020

C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease.

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12 December 2020

Phosphorylation of tau by proline-directed protein kinase (p34cdc2/p58cyclin A) decreases tau-induced microtubule assembly and antibody SMI33 reactivity.

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12 December 2020

Pyramidal cell topography of microtubule-associated proteins and their precipitation into paired helical filaments.

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12 December 2020

Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture.

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12 December 2020

The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase

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12 December 2020

Controlling beta-sheet assembly in genetically engineered silk by enzymatic phosphorylation/dephosphorylation

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12 December 2020

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

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12 December 2020

Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor

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12 December 2020

Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease

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12 December 2020

Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal

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12 December 2020

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

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12 December 2020

Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

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12 December 2020

p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]

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12 December 2020

Conformational change as one of the earliest alterations of tau in Alzheimer's disease.

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12 December 2020

Age-related modifications of MAP-2.

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12 December 2020

Quantitation and characterization of tau factor in porcine tissues.

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12 December 2020

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

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12 December 2020

Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease

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12 December 2020

Altered microtubule organization in small-calibre axons of mice lacking tau protein

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12 December 2020

Developmentally regulated expression of specific tau sequences

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12 December 2020

Identification and partial characterization of a candidate gene for X-linked retinopathies using a lateral approach

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12 December 2020

The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis

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12 December 2020

Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins

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12 December 2020

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

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12 December 2020

Changes in phosphorylation of tau during ischemia and reperfusion in the rabbit spinal cord.

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12 December 2020

Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins

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12 December 2020

Molecular dissection of the neurofibrillary lesions of Alzheimer's disease

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12 December 2020

Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease

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12 December 2020

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

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12 December 2020

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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12 December 2020

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

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12 December 2020

Identification of a tau promoter region mediating tissue-specific-regulated expression in PC12 cells.

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12 December 2020

Transgenic mouse models of tauopathies: prospects for animal models of Pick's disease

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12 December 2020

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.

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12 December 2020

Phosphorylated tau can promote tubulin assembly

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12 December 2020

Interaction between microtubule-associated protein tau and spectrin

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12 December 2020

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

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12 December 2020

Along the way to a neurofibrillary tangle: a look at the structure of tau.

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12 December 2020

Structural characterization of the core of the paired helical filament of Alzheimer disease

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12 December 2020

A tau promoter region without neuronal specificity.

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12 December 2020

Tau factor polymers are similar to paired helical filaments of Alzheimer's disease

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12 December 2020

Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase

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12 December 2020

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

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12 December 2020

Oxidative regulation of fatty acid-induced tau polymerization.

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12 December 2020

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

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12 December 2020

Regionally selective changes in brain lysosomes occur in the transition from young adulthood to middle age in rats

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12 December 2020

Microtubule bundling by tau proteins in vivo: analysis of functional domains

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12 December 2020

Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly

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12 December 2020

Differential phosphorylation of tau by cyclic AMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase II: metabolic and functional consequences

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12 December 2020

Structural and functional implications of tau hyperphosphorylation: information from phosphorylation-mimicking mutated tau proteins.

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12 December 2020

Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease.

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12 December 2020

Alzheimer's disease: clues from flies and worms

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12 December 2020

Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes

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12 December 2020

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

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12 December 2020

Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assembly

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12 December 2020

Tau aggregation into fibrillar polymers: taupathies

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12 December 2020

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

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12 December 2020

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

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12 December 2020

Purification of tau protein from brain.

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12 December 2020

The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease

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12 December 2020

Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice.

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12 December 2020

Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.

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12 December 2020

Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene: expansion of the disease phenotype caused by tau gene mutations.

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12 December 2020

The deposition of amyloid proteins in the aging mammalian brain: implications for Alzheimer's disease

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12 December 2020

Alzheimer's disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon's horn.

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12 December 2020

Role of glycosaminoglycans in determining the helicity of paired helical filaments

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12 December 2020

A neuronal antigen in the brains of Alzheimer patients

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12 December 2020

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

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12 December 2020

The distribution of tau in the mammalian central nervous system

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12 December 2020

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

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12 December 2020

Activation of phospholipase C-gamma by the concerted action of tau proteins and arachidonic acid

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12 December 2020

Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis

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12 December 2020

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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12 December 2020

In vitro polymerization of oxidized tau into filaments.

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12 December 2020

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

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12 December 2020

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

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12 December 2020

Protein phosphatase 2A: a panoply of enzymes.

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12 December 2020

Casein kinase II preferentially phosphorylates human tau isoforms containing an amino-terminal insert. Identification of threonine 39 as the primary phosphate acceptor.

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12 December 2020

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

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12 December 2020

Normal and pathological Tau proteins as factors for microtubule assembly.

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12 December 2020

The naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathway

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12 December 2020

Differences in microtubule binding and self-association abilities of bovine brain tau isoforms.

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12 December 2020

Primary structure of high molecular weight tau present in the peripheral nervous system

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12 December 2020

Tau interacts with src-family non-receptor tyrosine kinases

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12 December 2020

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

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12 December 2020

The molecular and cellular pathology of Alzheimer neurofibrillary lesions

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12 December 2020

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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12 December 2020

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

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12 December 2020

Frequency of stages of Alzheimer-related lesions in different age categories

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12 December 2020

Alzheimer's paired helical filaments

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12 December 2020

Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease

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12 December 2020

Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules

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12 December 2020

A protein factor essential for microtubule assembly

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12 December 2020

Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly.

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12 December 2020

Identification and characterization of the ATP.Mg-dependent protein phosphatase activator (FA) as a microtubule protein kinase in the brain

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12 December 2020

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

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12 December 2020

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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12 December 2020

RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

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12 December 2020

Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau.

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12 December 2020

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

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12 December 2020

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

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12 December 2020

A progressive deposition of paired helical filaments (PHF) in the brain characterizes the evolution of dementia in Alzheimer's disease. An immunocytochemical study with a monoclonal antibody against the PHF core.

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12 December 2020

Tau dephosphorylation at tau-1 site correlates with its association to cell membrane

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12 December 2020

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

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12 December 2020

A modified form of microtubule-associated tau protein is the main component of paired helical filaments.

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12 December 2020

Tau proteins: the molecular structure and mode of binding on microtubules

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12 December 2020

Sulphated glycosaminoglycans prevent the neurotoxicity of a human prion protein fragment

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12 December 2020

Phosphorylation of mitogen-activated protein kinase is altered in neuroectodermal cells overexpressing the human amyloid precursor protein 751 isoform

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12 December 2020

Tau filament formation in transgenic mice expressing P301L tau.

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12 December 2020

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

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12 December 2020

Effects of brain microtubule-associated proteins on microtubule dynamics and the nucleating activity of centrosomes

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12 December 2020

Phosphorylation determines two distinct species of Tau in the central nervous system.

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12 December 2020

Identification of the major multiphosphorylation site in mammalian neurofilaments

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12 December 2020

Molecular dissection of the paired helical filament

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12 December 2020

Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain

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12 December 2020

Tau and transgenic animal models

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12 December 2020

Modulation of tau phosphorylation and intracellular localization by cellular stress

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12 December 2020

The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes.

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12 December 2020

The primary structure and heterogeneity of tau protein from mouse brain.

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12 December 2020

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress

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12 December 2020

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

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12 December 2020

Characterization of microtubule-associated protein phosphoisoforms present in isolated growth cones

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12 December 2020

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

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12 December 2020

Tau promoter confers neuronal specificity and binds Sp1 and AP-2

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12 December 2020

Neurodegenerative tauopathies

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12 December 2020

Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.

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12 December 2020

Molecular dissection of the neurofibrillary lesions of Alzheimer's disease

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12 December 2020

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

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12 December 2020

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

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12 December 2020

Tau epitopes in spinal cord neurofibrillary lesions in Chamorros of Guam

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12 December 2020

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

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12 December 2020

Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family

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12 December 2020

Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system

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12 December 2020

Functional organization of microtubule-associated protein tau. Identification of regions which affect microtubule growth, nucleation, and bundle formation in vitro.

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12 December 2020

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

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12 December 2020

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

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12 December 2020

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform

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12 December 2020

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

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12 December 2020

Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease

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12 December 2020

Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau.

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12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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12 December 2020

Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

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12 December 2020

Tau protein in Alzheimer's disease

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12 December 2020

Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein

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12 December 2020

Tau in situ hybridization in normal and Alzheimer brain: localization in the somatodendritic compartment.

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12 December 2020

FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain

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12 December 2020

Microtubule assembly in vitro. Purification of assembly-promoting factors.

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12 December 2020

Tau is a candidate gene for chromosome 17 frontotemporal dementia

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12 December 2020

Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta

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12 December 2020

The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP-2, is also involved in actin binding

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12 December 2020

Dietary aluminum selectively decreases MAP-2 in brains of developing and adult rats

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12 December 2020

Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy

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12 December 2020

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

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12 December 2020

Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

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12 December 2020

Tau complexes with phospholipase C-gamma in situ

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12 December 2020

Amyloid plaques, neurofibrillary tangles and their relevance for the study of Alzheimer's disease

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12 December 2020

Identifiers

DOI

10.1385/MN:25:3:213

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Dimensions Publication ID

4 August 2017

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