(Q34731582)

4 August 2017

title

Aging of the Innate Immune System: An Update (English)

1 reference

4 August 2017

Shegufta Mahbub

1

1 reference

4 August 2017

Aleah L Brubaker

series ordinal

2

1 reference

4 August 2017

Elizabeth J Kovacs

series ordinal

3

1 reference

4 August 2017

publication date

1 February 2011

1 reference

Current Immunology Reviews

4 August 2017

published in

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4 August 2017

volume

7

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4 August 2017

issue

1

1 reference

4 August 2017

page(s)

104-115

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Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection

4 August 2017

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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NK and NKT cells in aging and longevity: role of zinc and metallothioneins

7 July 2018

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Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA

7 July 2018

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Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen

7 July 2018

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Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation

7 July 2018

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Aging and neutrophils: there is still much to do.

7 July 2018

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Molecular inflammation: underpinnings of aging and age-related diseases

7 July 2018

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Aging and animal models of systemic insult: trauma, burn, and sepsis

7 July 2018

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Innate immunity and aging

7 July 2018

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Aging and impairment of innate immunity

7 July 2018

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Dysregulation of TLR3 Impairs the Innate Immune Response to West Nile Virus in the Elderly

7 July 2018

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Effect of senescence on macrophage polarization and angiogenesis

7 July 2018

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Biology of dendritic cells in aging

7 July 2018

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Toll-like receptors in older adults

7 July 2018

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Getting to the site of inflammation: the leukocyte adhesion cascade updated

7 July 2018

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Neutrophil granules: a library of innate immunity proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Pulmonary effects of inhaled limonene ozone reaction products in elderly rats

7 July 2018

1 reference

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Invariant NKT and NKT-like lymphocytes: two different T cell subsets that are differentially affected by ageing

7 July 2018

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7 July 2018

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Aberrant acute-phase response in aged interleukin-6 knockout mice

7 July 2018

1 reference

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Dendritic cells in a mature age.

7 July 2018

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The aging innate immune system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

How neutrophils kill microbes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Signal transduction and functional changes in neutrophils with aging.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

NK and NKT cell functions in immunosenescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Innate immunity in aging: impact on macrophage function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Aging and innate immune cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

7 July 2018

Aging and wound healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

The central role of dendritic cells and interferon-alpha in SLE.

7 July 2018

1 reference

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Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Alternative activation of macrophages

7 July 2018

1 reference

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A meta-analysis of effectiveness of influenza vaccine in persons aged 65 years and over living in the community.

7 July 2018

1 reference

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RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Neutrophil ageing and immunesenescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Inflamm-aging. An evolutionary perspective on immunosenescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

NK and NK/T cells in human senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Integrin signal transduction in myeloid leukocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Signal transduction in LPS-activated aged and young monocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Senescence and cytokines modulate the NK cell expression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Neutrophil migration, oxidative metabolism, and adhesion in elderly and young subjects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Neutrophil adhesion in the elderly: inhibitory effects of plasma from elderly patients

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Immunosenescence of human NK cells: effects on tumor target recognition, lethal hit and interferon sensitivity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

NF-kappaB signaling in the aging process

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

A role for IL-18 in human neutrophil apoptosis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Role of inositol 1,4,5-triphosphate and p38 mitogen-activated protein kinase in reactive oxygen species generation by granulocytes in a cyclic AMP-dependent manner: an age-related phenomenon.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

The variations during the circadian cycle of liver CD1d-unrestricted NK1.1+TCR gamma/delta+ cells lead to successful ageing. Role of metallothionein/IL-6/gp130/PARP-1 interplay in very old mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Macrophage hypo-responsiveness to interferon-gamma in aged mice is associated with impaired signaling through Jak-STAT.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Cytokine requirements for the growth and development of mouse NK cells in vitro.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Age-dependent change in reactive oxygen species and nitric oxide generation by rat alveolar macrophages.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Chemokine production by natural killer cells from nonagenarians

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Association between natural killer cell activity and infection in immunologically normal elderly people

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

NK phenotypic markers and IL2 response in NK cells from elderly people.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Age-dependent decreases of NK cell phosphoinositide turnover during spontaneous but not Fc-mediated cytolytic activity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Effects of aging on natural killer cell activity and activation by interleukin-2 and IFN-alpha

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066013

Tumour necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing

26 October 2018

1 reference

12 December 2020

IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation

1 reference

12 December 2020

Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization

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12 December 2020

Interferon-gamma-induced priming for secretion of superoxide anion and tumor necrosis factor-alpha declines in macrophages from aged rats

1 reference

12 December 2020

Peripheral blood dendritic cells and monocytes are differently regulated in the elderly

1 reference

12 December 2020

Telomere Shortening and Oxidative Stress in Aged Macrophages Results in Impaired STAT5a Phosphorylation

1 reference

12 December 2020

Dysregulation of IL-10 production with aging: possible linkage to the age-associated decline in DHEA and its sulfated derivative

1 reference

12 December 2020

Admission criteria for immunogerontological studies in man: the SENIEUR protocol

1 reference

12 December 2020

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12 December 2020

Cytokine production and aging: overproduction of IL-8 in elderly males in response to lipopolysaccharide

1 reference

12 December 2020

Effect of aging on murine macrophages. Diminished response to IFN-gamma for enhanced oxidative metabolism

1 reference

12 December 2020

Impaired wound repair and delayed angiogenesis in aged mice

1 reference

12 December 2020

CD1d-restricted NKT cells contribute to the age-associated decline of T cell immunity

1 reference

12 December 2020

Effect of age on marrow macrophage number and function

1 reference

12 December 2020

An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition

1 reference

12 December 2020

Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression

1 reference

12 December 2020

Ageing and Toll-like receptor expression by innate immune cells in chronic human schistosomiasis

1 reference

12 December 2020

Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock?

1 reference

12 December 2020

Enhanced expression of inducible cyclooxygenase with age in murine macrophages

1 reference

12 December 2020

The function and fate of neutrophils at the inflamed site: prospects for therapeutic intervention

1 reference

12 December 2020

Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply

1 reference

12 December 2020

Cutting edge: impaired Toll-like receptor expression and function in aging

1 reference

12 December 2020

Age-associated defect in human TLR-1/2 function

1 reference

12 December 2020

The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function

1 reference

12 December 2020

Decreased frequency and proliferative response of invariant Vα24Vβ11 natural killer T (iNKT) cells in healthy elderly

1 reference

12 December 2020

Vα24+ NKT cells are decreased in elderly humans

1 reference

12 December 2020

[Age-dependent distribution of Langerhans cells within human conjunctival epithelium]

1 reference

12 December 2020

Perforins in human cytolytic cells: the effect of age

1 reference

12 December 2020

Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4

1 reference

12 December 2020

From transcription to cell surface expression, the induction of MHC class II I-Aα by interferon-γ in macrophages is regulated at different levels

1 reference

12 December 2020

Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans

1 reference

12 December 2020

Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly

1 reference

12 December 2020

Chronic exercise increases macrophage-mediated tumor cytolysis in young and old mice

1 reference

12 December 2020

1 reference

12 December 2020

Modulation of epidermal Langerhans' cell frequency by tumour necrosis factor-alpha

1 reference

12 December 2020

Effect of age on second messenger generation in neutrophils

1 reference

12 December 2020

Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis

1 reference

12 December 2020

Monocyte chemiluminescence and macrophage precursors in the aged

1 reference

12 December 2020

Influence of aging on murine neutrophil and macrophage function against Candida albicans

1 reference

12 December 2020

Dendritic cells in vivo: a key target for a new vaccine science

1 reference

12 December 2020

Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells

1 reference

12 December 2020

Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing

1 reference

12 December 2020

10.2174/157339511794474181

Identifiers

DOI

1 reference

4 August 2017

1 reference

4 August 2017

1 reference