(Q34732905)

4 August 2017

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title

The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery (English)

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4 August 2017

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Alun Bermingham

1

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4 August 2017

Jeremy P Derrick

series ordinal

2

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4 August 2017

language of work or name

English

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publication date

1 July 2002

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4 August 2017

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4 August 2017

volume

24

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4 August 2017

issue

7

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4 August 2017

page(s)

637-648

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Replacement of the folC gene, encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli, with genes mutagenized in vitro

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Adaptation to sulfonamide resistance in Neisseria meningitidis may have required compensatory changes to retain enzyme function: kinetic analysis of dihydropteroate synthases from N. meningitidis expressed in a knockout mutant of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

A metabolic node in action: chorismate-utilizing enzymes in microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

The antimicrobial activities of trimethoprim and sulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Atomic structure of GTP cyclohydrolase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Zinc plays a key role in human and bacterial GTP cyclohydrolase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Active site topology and reaction mechanism of GTP cyclohydrolase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Biosynthesis of pteridines. Stopped-flow kinetic analysis of GTP cyclohydrolase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Crystal structure of 7,8-dihydroneopterin triphosphate epimerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Purification, cloning, and functional expression of dihydroneopterin triphosphate 2'-epimerase from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

A vibrational structure of 7,8-dihydrobiopterin bound to dihydroneopterin aldolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Inhibitors of folate biosynthesis. 1. Inhibition of dihydroneopterin aldolase by pteridine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

2.0 A X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Unusual conformational changes in 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as revealed by X-ray crystallography and NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Structure and function of the dihydropteroate synthase from Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Dihydropteroate synthase from Streptococcus pneumoniae: characterization of substrate binding order and sulfonamide inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Monocyclic pteridine analogues. Inhibition of Escherichia coli dihydropteroate synthase by 6-amino-5-nitrosoisocytosines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Inhibitors of dihydropteroate synthase: substituent effects in the side-chain aromatic ring of 6-[[3-(aryloxy)propyl]amino]-5-nitrosoisocytosines and synthesis and inhibitory potency of bridged 5-nitrosoisocytosine-p-aminobenzoic acid analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Regulatory role of oxidized and reduced pteroylpolyglutamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Mutagenesis of the Lactobacillus casei folylpolyglutamate synthetase gene at essential residues resembling an ATP binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Folate-binding triggers the activation of folylpolyglutamate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Structural and functional similarities in the ADP-forming amide bond ligase superfamily: implications for a substrate-induced conformational change in folylpolyglutamate synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Channeling of substrates and intermediates in enzyme-catalyzed reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

The molecular basis of substrate channeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10114

21 January 2018

Identifiers

DOI

10.1002/BIES.10114

1 reference

release_ptoyjfqej5gwjpyltq45mmizou

4 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ptoyjfqej5gwjpyltq45mmizou

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference