(Q34733047)

4 August 2017

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title

Role of Bcl-2 family of proteins in malignancy (English)

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4 August 2017

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Sharad Kumar

2

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author name string

Belinda C Baliga

series ordinal

1

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4 August 2017

1 June 2002

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4 August 2017

Hematological Oncology

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4 August 2017

20

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4 August 2017

63-74

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4 August 2017

2

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

4 August 2017

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Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

21 January 2018

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Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

21 January 2018

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

21 January 2018

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 January 2018

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Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

21 January 2018

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Role of BAX in the apoptotic response to anticancer agents

21 January 2018

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Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

21 January 2018

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BCL-2 family members and the mitochondria in apoptosis

21 January 2018

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Bcl-2-family proteins: the role of the BH3 domain in apoptosis.

21 January 2018

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

21 January 2018

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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

21 January 2018

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Regulated targeting of BAX to mitochondria.

21 January 2018

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 January 2018

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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Genetic control of programmed cell death in the nematode C. elegans.

21 January 2018

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C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

21 January 2018

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Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

21 January 2018

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The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

21 January 2018

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Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery.

21 January 2018

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Cloning and characterization of a novel nuclear Bcl-2 family protein, zfMcl-1a, in zebrafish embryo.

21 January 2018

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An evolutionary perspective on apoptosis.

21 January 2018

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The fight of viruses against apoptosis

21 January 2018

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Genetic control of programmed cell death in Drosophila

21 January 2018

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Cell death in the fly comes of age.

21 January 2018

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Regulation and execution of apoptosis during Drosophila development

21 January 2018

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Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila.

21 January 2018

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21 January 2018

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Caspase structure, proteolytic substrates, and function during apoptotic cell death

21 January 2018

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

21 January 2018

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21 January 2018

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Mechanisms mediating caspase activation in cell death

21 January 2018

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Prodomains--adaptors--oligomerization: the pursuit of caspase activation in apoptosis.

21 January 2018

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

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Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

21 January 2018

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Bax directly induces release of cytochrome c from isolated mitochondria

21 January 2018

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Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

21 January 2018

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Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

21 January 2018

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Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

21 January 2018

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The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol

21 January 2018

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

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Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

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Solution structure of BID, an intracellular amplifier of apoptotic signaling

21 January 2018

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Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

21 January 2018

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Bcl-2 family proteins as ion-channels

21 January 2018

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Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

21 January 2018

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Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c.

21 January 2018

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Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

21 January 2018

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Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

21 January 2018

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Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

21 January 2018

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Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

21 January 2018

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Injected cytochrome c induces apoptosis

21 January 2018

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Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

21 January 2018

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

21 January 2018

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Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

21 January 2018

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Testicular degeneration in Bclw-deficient mice

21 January 2018

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Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

21 January 2018

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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Pleiotropic drug resistance in B-cell chronic lymphocytic leukaemia--the role of Bcl-2 family dysregulation.

21 January 2018

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Human Bcl-2 antisense therapy for lymphomas

21 January 2018

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Chemosensitisation of malignant melanoma by BCL2 antisense therapy

21 January 2018

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In vitro down-regulation of bcl-2 expression by all-trans retinoic acid in AML blasts

21 January 2018

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The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review

21 January 2018

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Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1

21 January 2018

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21 January 2018

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Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

21 January 2018

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Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

21 January 2018

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Prevention of neuronal cell death by Bcl-2

21 January 2018

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7 January 2021

The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition

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7 January 2021

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

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7 January 2021

Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine

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7 January 2021

Expression of bcl-2 and bax in cells isolated from B-chronic lymphocytic leukemia patients at different stages of the disease

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7 January 2021

Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid

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7 January 2021

Identifiers

DOI

10.1002/HON.685

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4 August 2017

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PubMed ID

12111869