(Q34734158)

4 August 2017

title

HCV 3a core protein increases lipid droplet cholesteryl ester content via a mechanism dependent on sphingolipid biosynthesis (English)

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4 August 2017

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8

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4 August 2017

Ursula Loizides-Mangold

object named as

Ursula Loizides-Mangold

1

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author name string

Sophie Clément

2

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4 August 2017

Alba Alfonso-Garcia

3

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4 August 2017

Emilie Branche

4

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4 August 2017

Stéphanie Conzelmann

5

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4 August 2017

Clotilde Parisot

6

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4 August 2017

Eric O Potma

7

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4 August 2017

Francesco Negro

9

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4 August 2017

language of work or name

English

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publication date

18 December 2014

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4 August 2017

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4 August 2017

volume

9

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4 August 2017

issue

12

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4 August 2017

page(s)

e115309

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Creative Commons Attribution 4.0 International

4 August 2017

copyright license

start time

18 December 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4270764/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus

7 July 2018

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Is genotype 3 of the hepatitis C virus the new villain?

7 July 2018

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1-O-acylceramides are natural components of human and mouse epidermis

7 July 2018

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PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism.

7 July 2018

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Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence

7 July 2018

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Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis

7 July 2018

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Glycosylphosphatidylinositol anchors regulate glycosphingolipid levels

7 July 2018

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What is killing people with hepatitis C virus infection?

7 July 2018

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Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis

7 July 2018

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Regulation of HMG-CoA reductase in mammals and yeast

7 July 2018

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Hepatic steatosis in hepatitis B virus infected patients: meta-analysis of risk factors and comparison with hepatitis C infected patients.

7 July 2018

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Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets.

7 July 2018

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Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome

7 July 2018

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Yeast lipid analysis and quantification by mass spectrometry

7 July 2018

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Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro

7 July 2018

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The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8.

7 July 2018

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The distribution and function of phosphatidylserine in cellular membranes

7 July 2018

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Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics

7 July 2018

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Do statins reduce hepatitis C RNA titers during routine clinical use?

7 July 2018

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Hepatitis C virus infection and its clearance alter circulating lipids: implications for long-term follow-up

7 July 2018

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Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

7 July 2018

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Recombinant adenoviruses expressing Steatosis-associated Hepatitis C virus genotype 3 Core protein produce intracellular lipid accumulation in cultured and primary hepatocytes

7 July 2018

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Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Targeting lipid metabolism in the treatment of hepatitis C virus infection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Different anti-HCV profiles of statins and their potential for combination therapy with interferon

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

An intimate collaboration between peroxisomes and lipid bodies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Host sphingolipid biosynthesis as a target for hepatitis C virus therapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Intracellular signal transduction pathways activated by ceramide and its metabolites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Titering lentiviral vectors: comparison of DNA, RNA and marker expression methods

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Tubulo-reticular clusters of peroxisomes in living COS-7 cells: dynamic behavior and association with lipid droplets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Hepatitis C virus core protein induces hepatic steatosis in transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Ceramide stimulates a cytosolic protein phosphatase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

PTEN upregulation may explain the development of insulin resistance and type 2 diabetes with high dose statins.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Changes in the expression of cholesterol metabolism-associated genes in HCV-infected liver: a novel target for therapy?

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: A randomized placebo-controlled trial.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

An open pilot study exploring the efficacy of fluvastatin, pegylated interferon and ribavirin in patients with hepatitis C virus genotype 1b in high viral loads.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Isolation of lipid droplets from cells by density gradient centrifugation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Effect of rosuvastatin on insulin sensitivity in an animal model of insulin resistance: evidence for statin-induced hepatic insulin sensitization

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

A lipidomic analysis of nonalcoholic fatty liver disease.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: a pilot clinical trial

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270764

Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis

26 October 2018

1 reference

12 December 2020

Increase in the concentration of carbon 18 monounsaturated fatty acids in the liver with hepatitis C: analysis in transgenic mice and humans

1 reference

12 December 2020

Analysis of triglyceride mixtures by gas chromatography-mass spectrometry

1 reference

12 December 2020

Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0115309

Identifiers

DOI

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4 August 2017

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4 August 2017

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