(Q34739706)

English

An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation.

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21173315%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21173315%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Brucella abortus

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inferred from title

Renée M Tsolis

6

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18 January 2020

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Athanasios Paschos

1

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18 January 2020

Andreas den Hartigh

2

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18 January 2020

Mark A Smith

3

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18 January 2020

Vidya L Atluri

4

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18 January 2020

Durga Sivanesan

5

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18 January 2020

Christian Baron

7

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18 January 2020

language of work or name

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20 December 2010

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18 January 2020

Infection and Immunity

1 reference

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18 January 2020

79

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18 January 2020

3

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Europe PubMed Central

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18 January 2020

1033-1043

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Europe PubMed Central

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18 January 2020

Antivirulence drugs to target bacterial secretion systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Structure of the outer membrane complex of a type IV secretion system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

The structural biology of type IV secretion systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Brucella regulators: self-control in a hostile environment.

1 reference

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7 July 2018

Brucellosis: a re-emerging zoonosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Structure of a type IV secretion system core complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Small-molecule type III secretion system inhibitors block assembly of the Shigella type III secreton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

An inhibitor of gram-negative bacterial virulence protein secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

VirB3 to VirB6 and VirB8 to VirB11, but not VirB7, are essential for mediating persistence of Brucella in the reticuloendothelial system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram-negative bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

The response regulator CpxR directly regulates expression of several Legionella pneumophila icm/dot components as well as new translocated substrates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Targeting virulence: a new paradigm for antimicrobial therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar typhimurium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Targeting bacterial secretion systems: benefits of disarmament in the microcosm.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

VirB8: a conserved type IV secretion system assembly factor and drug target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Inhibitors of Helicobacter pylori ATPase Cagalpha block CagA transport and cag virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

An integrated approach to functional genomics: construction of a novel reporter gene fusion library for Sinorhizobium meliloti

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Swapping of periplasmic domains between Brucella suis VirB8 and a pSB102 VirB8 homologue allows heterologous complementation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Dimerization and interactions of Brucella suis VirB8 with VirB4 and VirB10 are required for its biological activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Type IV secretion systems and their effectors in bacterial pathogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Unsaturated fatty acids are inhibitors of bacterial conjugation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

From bioremediation to biowarfare: on the impact and mechanism of type IV secretion systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Biogenesis, architecture, and function of bacterial type IV secretion systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Laboratory exposures to brucellae and implications for bioterrorism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Spatial location and requirements for the assembly of the Agrobacterium tumefaciens type IV secretion apparatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Small-molecule inhibitors specifically targeting type III secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Antibacterial resistance worldwide: causes, challenges and responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Differential requirements for VirB1 and VirB2 during Brucella abortus infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Definition of a bacterial type IV secretion pathway for a DNA substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Organelle robbery: Brucella interactions with the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Exploiting genomics, genetics and chemistry to combat antibiotic resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Targeting bacterial virulence: inhibitors of type III secretion in Yersinia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Brucellosis: a worldwide zoonosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

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7 July 2018

The Agrobacterium T-DNA transport pore proteins VirB8, VirB9, and VirB10 interact with one another

1 reference

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7 July 2018

Response of Brucella suis 1330 and B. canis RM6/66 to growth at acid pH and induction of an adaptive acid tolerance response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

7 July 2018

An overview of human brucellosis

1 reference

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7 July 2018

A quorum-sensing regulator controls expression of both the type IV secretion system and the flagellar apparatus of Brucella melitensis

1 reference

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26 October 2018

A Large Domain Swap in the VirB11 ATPase of Brucella suis Leaves the Hexameric Assembly Intact

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067494

26 October 2018

Where will new antibiotics come from?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21173315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of VirB8-VirB9-VirB10 interactions provides a dynamic model of type IV secretion system core complex assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/21173315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/IAI.00993-10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21173315%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21173315%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21173315%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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