(Q35140829)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12776213%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

review article

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title

Exploiting genomics, genetics and chemistry to combat antibiotic resistance (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12776213%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference

antibiotic resistance

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1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12776213%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

author name string

Diarmaid Hughes

series ordinal

1

1 reference

6 August 2017

publication date

1 June 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12776213%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

published in

Nature Reviews Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12776213%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12776213%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12776213%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

page(s)

432-441

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12776213%20AND%20SRC:MED&resulttype=core&format=json

Staphylococcus aureus infections

4 November 2019

cites work

1 reference

Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.

31 March 2020

1 reference

Strategies against multidrug-resistant tuberculosis.

31 March 2020

1 reference

Current medical treatment for tuberculosis

31 March 2020

1 reference

Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid

31 March 2020

1 reference

Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat

31 March 2020

1 reference

Treatment of drug-resistant pneumococcal pneumonia

31 March 2020

1 reference

Molecular mechanisms that confer antibacterial drug resistance

31 March 2020

1 reference

The rise and fall of antimicrobial resistance

31 March 2020

1 reference

High mutation frequencies among Escherichia coli and Salmonella pathogens

31 March 2020

1 reference

An elevated mutation frequency favors development of vancomycin resistance in Staphylococcus aureus

31 March 2020

1 reference

Emergence, spread, and environmental effect of antimicrobial resistance: how use of an antimicrobial anywhere can increase resistance to any antimicrobial anywhere else

31 March 2020

1 reference

Glycopeptide-resistant enterococci: a decade of experience

31 March 2020

1 reference

The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance

31 March 2020

1 reference

Risk factors for the transmission of methicillin-resistant Staphylococcus aureus in an adult intensive care unit: fitting a model to the data

31 March 2020

1 reference

Fitness of antibiotic-resistant microorganisms and compensatory mutations.

31 March 2020

1 reference

The biological cost of antibiotic resistance

31 March 2020

1 reference

Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

31 March 2020

1 reference

Historical changes in pneumococcal serogroup distribution: implications for the era of pneumococcal conjugate vaccines.

31 March 2020

1 reference

Secrets of success of a human pathogen: molecular evolution of pandemic clones of meticillin-resistant Staphylococcus aureus.

31 March 2020

1 reference

Rational identification of new antibacterial drug targets that are essential for viability using a genomics-based approach

31 March 2020

1 reference

Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae

31 March 2020

1 reference

Pilot study of the genetic diversity of the pneumococcal nasopharyngeal flora among children attending day care centers

31 March 2020

1 reference

Diversity of penicillin-nonsusceptible Streptococcus pneumoniae circulating in Iceland after the introduction of penicillin-resistant clone Spain(6B)-2.

31 March 2020

1 reference

From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathways

31 March 2020

1 reference

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae

31 March 2020

1 reference

Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA.

31 March 2020

1 reference

New strategies for antibacterial drug design

31 March 2020

1 reference

Detection and analysis of gene expression during infection by in vivo expression technology

31 March 2020

1 reference

Fluorescence-based isolation of bacterial genes expressed within host cells

31 March 2020

1 reference

Simultaneous identification of bacterial virulence genes by negative selection.

31 March 2020

1 reference

Use of signature-tagged mutagenesis in pathogenesis studies

31 March 2020

1 reference

Signature Tagged Mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival

31 March 2020

1 reference

Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis

31 March 2020

1 reference

Staphylococcus aureus svrA: a gene required for virulence and expression of the agr locus

31 March 2020

1 reference

Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract.

31 March 2020

1 reference

Identification of in vivo essential genes from Pseudomonas aeruginosa by PCR-based signature-tagged mutagenesis

31 March 2020

1 reference

Identification of new genes involved in the virulence of Listeria monocytogenes by signature-tagged transposon mutagenesis.

31 March 2020

1 reference

Functional genomics of Neisseria meningitidis pathogenesis

31 March 2020

1 reference

Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis

31 March 2020

1 reference

Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

31 March 2020

1 reference

Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae

31 March 2020

1 reference

A functional genomic analysis of type 3 Streptococcus pneumoniae virulence

31 March 2020

1 reference

Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization

31 March 2020

1 reference

Drug target validation: lethal infection blocked by inducible peptide

31 March 2020

1 reference

Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A

31 March 2020

1 reference

A potent seryl tRNA synthetase inhibitor SB-217452 isolated from a Streptomyces species

31 March 2020

1 reference

Microbial technologies for the discovery of novel bioactive metabolites.

31 March 2020

1 reference

Synthetic combinatorial libraries: novel discovery strategy for identification of antimicrobial agents.

31 March 2020

1 reference

Comprehensive survey of combinatorial library synthesis: 2001.

31 March 2020

1 reference

Screening for novel antimicrobials from encoded combinatorial libraries by using a two-dimensional agar format.

31 March 2020

1 reference

Site-directed ligand discovery

31 March 2020

1 reference

Structure-activity relationship investigations of a potent and selective benzodiazepine oxytocin antagonist

31 March 2020

1 reference

Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives

31 March 2020

1 reference

Target-oriented and diversity-oriented organic synthesis in drug discovery

31 March 2020

1 reference

Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays.

31 March 2020

1 reference

Synthesis of 7-substituted tetracycline derivatives.

31 March 2020

1 reference

Solid-phase synthesis of macrolide analogues

31 March 2020

1 reference

Discovery of novel disaccharide antibacterial agents using a combinatorial library approach

31 March 2020

1 reference

Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase

31 March 2020

1 reference

The role of combichem in antibiotic discovery

31 March 2020

1 reference

Recent developments in structure-based drug design

31 March 2020

1 reference

Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

31 March 2020

1 reference

N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity

31 March 2020

1 reference

Combinatorial biosynthesis of antimicrobials and other natural products

31 March 2020

1 reference

Harnessing the biosynthetic code: combinations, permutations, and mutations

31 March 2020

1 reference

The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases

31 March 2020

1 reference

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

31 March 2020

1 reference

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides

31 March 2020

1 reference

C-O bond formation by polyketide synthases

31 March 2020

1 reference

Beta-lactamase-inhibitor combinations in the 21st century: current agents and new developments

31 March 2020

1 reference

Multiple antibiotic resistance and efflux

31 March 2020

1 reference

Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon.

31 March 2020

1 reference

Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.

31 March 2020

1 reference

A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus

31 March 2020

1 reference

Phenothiazines and thioxanthenes inhibit multidrug efflux pump activity in Staphylococcus aureus

31 March 2020

1 reference

Reversal of tetracycline resistance mediated by different bacterial tetracycline resistance determinants by an inhibitor of the Tet(B) antiport protein.

31 March 2020

1 reference

Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin

31 March 2020

1 reference

Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy

31 March 2020

1 reference

Crystal structure of bacterial multidrug efflux transporter AcrB

31 March 2020

1 reference

On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition

31 March 2020

1 reference

Virulence of antibiotic-resistant Salmonella typhimurium

31 March 2020

1 reference

Fitness cost of chromosomal drug resistance-conferring mutations

31 March 2020

1 reference

The dynamic structure of EF-G studied by fusidic acid resistance and internal revertants.

31 March 2020

1 reference

Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium.

31 March 2020

1 reference

Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance

31 March 2020

1 reference

Reducing antibiotic resistance.

31 March 2020

1 reference

Specificity of induction of glycopeptide resistance genes in Enterococcus faecalis

31 March 2020

1 reference

The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland. Finnish Study Group for Antimicrobial Resistance

31 March 2020

1 reference

Development of beta-lactamase-mediated resistance to penicillin in middle-ear isolates of Moraxella catarrhalis in Finnish children, 1978-1993.

31 March 2020

1 reference

Effect of antimicrobial use and other risk factors on antimicrobial resistance in pneumococci

31 March 2020

1 reference

The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptions

31 March 2020

1 reference

Understanding the spread of antibiotic resistant pathogens in hospitals: mathematical models as tools for control

31 March 2020

1 reference

Toward rapid real-time molecular diagnostic to guide smart use of antimicrobials

31 March 2020

1 reference

Combining nucleic acid amplification and detection

31 March 2020

1 reference

Molecular detection of antimicrobial resistance

31 March 2020

1 reference

New real-time PCR able to detect in a single tube multiple rifampin resistance mutations and high-level isoniazid resistance mutations in Mycobacterium tuberculosis

31 March 2020

1 reference

In vitro bactericidal activities of linezolid in combination with vancomycin, gentamicin, ciprofloxacin, fusidic acid, and rifampin against Staphylococcus aureus

31 March 2020

1 reference

Activities of moxifloxacin alone and in combination with other antimicrobial agents against multidrug-resistant Mycobacterium tuberculosis infection in BALB/c mice.

31 March 2020

1 reference

Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studies

31 March 2020

1 reference

Restricting the selection of antibiotic-resistant mutant bacteria: measurement and potential use of the mutant selection window

31 March 2020

1 reference

Mutant prevention concentrations of fluoroquinolones for clinical isolates of Streptococcus pneumoniae.

31 March 2020

1 reference

The UK Hib vaccine experience

31 March 2020

1 reference

Efficacy of meningococcal serogroup C conjugate vaccine in teenagers and toddlers in England

31 March 2020

1 reference

The new pneumococcal vaccine

31 March 2020

1 reference

Use of a Staphylococcus aureus conjugate vaccine in patients receiving hemodialysis.

31 March 2020

1 reference

Comparative genomics and understanding of microbial biology

31 March 2020

1 reference

Functional genomics of pathogenic bacteria

31 March 2020

1 reference

Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection

31 March 2020

1 reference

Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.

31 March 2020

1 reference

NadA, a novel vaccine candidate of Neisseria meningitidis

31 March 2020

1 reference

Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics.

31 March 2020

1 reference

31 March 2020

The meningococcus tamed?

1 reference

31 March 2020

Bacteriophage therapy

1 reference

Dynamics of success and failure in phage and antibiotic therapy in experimental infections

31 March 2020

1 reference

Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium

31 March 2020

1 reference

Novel antibacterial agents for the treatment of serious Gram-positive infections

31 March 2020

1 reference

Mechanism of action of oritavancin and related glycopeptide antibiotics

31 March 2020

1 reference

Microbiology of newer fluoroquinolones: focus on respiratory pathogens

31 March 2020

1 reference

New (and not so new) antibacterial targets - from where and when will the novel drugs come?

31 March 2020

1 reference

Antimicrobials: new solutions badly needed

31 March 2020

1 reference

Bioterrorism and patent rights: "compulsory licensure" and the case of Cipro

31 March 2020

1 reference

The food safety perspective of antibiotic resistance

31 March 2020

1 reference

The EU precautionary bans of animal feed additive antibiotics

31 March 2020

1 reference

A new mechanism of antibiotic resistance in Enterobacteriaceae induced by a structural modification of the major porin.

31 March 2020

1 reference

Multidrug resistance in Gram-negative bacteria.

31 March 2020

1 reference

Efflux-mediated drug resistance in Gram-positive bacteria

31 March 2020

1 reference

Emerging mechanisms of fluoroquinolone resistance

31 March 2020

1 reference

Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants

31 March 2020

1 reference

Mosaic genes and mosaic chromosomes: intra- and interspecies genomic variation of Streptococcus pneumoniae

31 March 2020

1 reference

Modular organization of genes required for complex polyketide biosynthesis

31 March 2020

1 reference

Intermodular communication in polyketide synthases: comparing the role of protein-protein interactions to those in other multidomain proteins

31 March 2020

1 reference

A multiplasmid approach to preparing large libraries of polyketides

31 March 2020

1 reference

Nonnatural substrates for polyketide synthases and their associated modifying enzymes

31 March 2020

1 reference

Mechanisms of glycopeptide resistance in enterococci

31 March 2020

1 reference