(Q34746192)

4 August 2017

Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor (English)

1 reference

4 August 2017

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15

Matthias H Tschöp

1 reference

4 August 2017

Vincent Bernard

7

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Paul T Pfluger

object named as

Paul T Pfluger

6

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Jef D Boeke

object named as

Jef D Boeke

16

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author name string

Brad P Barnett

1

1 reference

4 August 2017

Yousang Hwang

2

1 reference

4 August 2017

Martin S Taylor

3

1 reference

4 August 2017

Martin S Taylor

4

1 reference

4 August 2017

Henriette Kirchner

5

1 reference

4 August 2017

Yu-yi Lin

8

1 reference

4 August 2017

Erin M Bowers

9

1 reference

4 August 2017

Chandrani Mukherjee

10

1 reference

4 August 2017

Woo-Jin Song

11

1 reference

4 August 2017

Patti A Longo

12

1 reference

4 August 2017

Daniel J Leahy

13

1 reference

4 August 2017

Mehboob A Hussain

14

1 reference

4 August 2017

Philip A Cole

17

1 reference

4 August 2017

language of work or name

English

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publication date

18 November 2010

1 reference

4 August 2017

1 reference

4 August 2017

330

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4 August 2017

6011

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4 August 2017

1689-1692

1 reference

Unraveling the role of the ghrelin gene peptides in the endocrine pancreas.

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

GOAT links dietary lipids with the endocrine control of energy balance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Introducing GOAT: a target for obesity and anti-diabetic drugs?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Effect of des-acyl ghrelin on adiposity and glucose metabolism.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ghrelin octanoylation mediated by an orphan lipid transferase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Mice lacking ghrelin receptors resist the development of diet-induced obesity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Mechanism-based design of a protein kinase inhibitor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ghrelin induces adiposity in rodents

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Effects of gender, body composition, and menopause on plasma concentrations of leptin.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Transgenic mice overexpressing des-acyl ghrelin show small phenotype.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

Ghrelin causes hyperphagia and obesity in rats.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068526

26 October 2018

Identifiers

DOI

10.1126/SCIENCE.1196154

1 reference

4 August 2017

1 reference

4 August 2017

1 reference