(Q34748167)

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The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear

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scholarly article

1 reference

Europe PubMed Central

4 August 2017

The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear (English)

1 reference

Europe PubMed Central

4 August 2017

Joseph E. Aslan

object named as

Joseph E Aslan

2

0 references

object named as

Brian J Druker

7

0 references

Owen J T McCarty

8

object named as

Owen J T McCarty

1 reference

Europe PubMed Central

4 August 2017

author name string

Cassandra P Loren

1

1 reference

Europe PubMed Central

4 August 2017

Rachel A Rigg

3

1 reference

Europe PubMed Central

4 August 2017

Marie S Nowak

4

1 reference

Europe PubMed Central

4 August 2017

Laura D Healy

5

1 reference

Europe PubMed Central

4 August 2017

András Gruber

6

1 reference

Europe PubMed Central

4 August 2017

publication date

18 November 2014

1 reference

Europe PubMed Central

4 August 2017

Thrombosis Research

1 reference

Europe PubMed Central

4 August 2017

135

1 reference

Europe PubMed Central

4 August 2017

1

1 reference

Europe PubMed Central

4 August 2017

155-160

1 reference

Europe PubMed Central

4 August 2017

Practical issues surrounding the explosion of tyrosine kinase inhibitors for the management of chronic myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic eosinophils carrying FIP1L1-PDGFRA

1 reference

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7 July 2018

Biomarkers for prediction of venous thromboembolism in cancer

1 reference

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7 July 2018

Efficacy of ponatinib against ABL tyrosine kinase inhibitor-resistant leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Synergistic growth-inhibitory effects of ponatinib and midostaurin (PKC412) on neoplastic mast cells carrying KIT D816V

1 reference

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7 July 2018

Biomolecular markers of cancer-associated thromboembolism

1 reference

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7 July 2018

Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1

1 reference

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7 July 2018

The growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABL

1 reference

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7 July 2018

Distinct and overlapping functional roles of Src family kinases in mouse platelets

1 reference

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7 July 2018

Platelet dysfunction associated with ponatinib, a new pan BCR-ABL inhibitor with efficacy for chronic myeloid leukemia resistant to multiple tyrosine kinase inhibitor therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.

1 reference

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7 July 2018

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation

1 reference

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7 July 2018

Promotion of experimental thrombus formation by the procoagulant activity of breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase includ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

The new tyrosine-kinase inhibitor and anticancer drug dasatinib reversibly affects platelet activation in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

GPVI and integrin alphaIIb beta3 signaling in platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Imatinib as a paradigm of targeted therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Exposure of platelet membrane phosphatidylserine regulates blood coagulation

1 reference

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7 July 2018

Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

1 reference

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7 July 2018

Regulation of Btk function by a major autophosphorylation site within the SH3 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

7 July 2018

Ponatinib pulled off market over safety issues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

26 October 2018

Platelet shape change and spreading.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272760

26 October 2018

P-selectin expression on platelets determines size and stability of platelet aggregates

1 reference

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26 October 2018

A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen.

1 reference

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26 October 2018

Identifiers

10.1016/J.THROMRES.2014.11.009

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

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