(Q34750366)

4 August 2017

1 reference

title

Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine). (English)

1 reference

4 August 2017

Andries M Bergman

1

1 reference

PubMed ID

12127861

4 August 2017

Herbert M Pinedo

series ordinal

2

1 reference

PubMed ID

12127861

4 August 2017

Godefridus J Peters

series ordinal

3

1 reference

4 August 2017

1 February 2002

1 reference

4 August 2017

Drug Resistance Updates

1 reference

4 August 2017

5

1 reference

4 August 2017

19-33

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4 August 2017

1

1 reference

Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: a phase II study

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Human ICE/CED-3 protease nomenclature

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Characterisation of genotoxic properties of 2',2'-difluorodeoxycytidine.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Kinetic studies on 2',2'-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

The role of gemcitabine in the treatment of other tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Gemcitabine induces programmed cell death and activates protein kinase C in BG-1 human ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

The role of p53 in gemcitabine-mediated cytotoxicity and radiosensitization.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Human T-lymphoblast deoxycytidine kinase: purification and properties

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

cDNA Technologies and their application to drug resistance research: power, potential and problems

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Drug resistance to 5-aza-2'-deoxycytidine, 2',2'-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

The biochemistry of P-glycoprotein-mediated multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Functional characterization of a recombinant sodium-dependent nucleoside transporter with selectivity for pyrimidine nucleosides (cNT1rat) by transient expression in cultured mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Kinetics and substrate specificity of human and canine cytidine deaminase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Apoptosis in cancer therapy: crossing the threshold

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Nucleoside and nucleobase transport systems of mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Gemcitabine: progress in the treatment of pancreatic cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

p53 mutations in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

p53-dependent growth arrest of REF52 cells containing newly amplified DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Induction of apoptosis in CD4+ prolymphocytic leukemia by deoxyadenosine and 2'-deoxycoformycin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

p53 expression overcomes p21WAF1/CIP1-mediated G1 arrest and induces apoptosis in human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Gemcitabine: current status of phase I and II trials

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Apoptosis. Its significance in cancer and cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

NMR structure of a gemcitabine-substituted model Okazaki fragment

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

The role of APO-1-mediated apoptosis in the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Mitochondrial toxicity of antiviral drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Effect of loss of DNA mismatch repair on development of topotecan-, gemcitabine-, and paclitaxel-resistant variants after exposure to cisplatin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Increased ratio between deoxycytidine kinase and thymidine kinase 2 in CLL lymphocytes compared to normal lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Molecular cloning of human cytosolic purine 5'-nucleotidase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Effects of gemcitabine on cell proliferation and apoptosis in non-small-cell lung cancer (NSCLC) cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Thymidylate synthase and drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Molecular effects of 2',2'-difluorodeoxycytidine (Gemcitabine) on DNA replication in intact HL-60 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

2',2'-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphosphate and uridine 5'-triphosphate in relation to chemosensitivity for 2',2'-difluorodeoxycytidine

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Induction of in vivo resistance against gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine).

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Gene amplification in cultured animal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Gemcitabine and radiosensitization in human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Postconfluent multilayered cell line cultures for selective screening of gemcitabine

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Poly(ADP-ribose) polymerase in DNA damage-response pathway: implications for radiation oncology

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

1 reference

7 January 2021

Recent progress in understanding mechanisms of mammalian DNA amplification

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

The role of deoxycytidine kinase in gemcitabine cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Genetic aspects of resistance to anticancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Cytosine arabinoside influx and nucleoside transport sites in acute leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Modulation of deoxycytidylate deaminase in intact human leukemia cells. Action of 2',2'-difluorodeoxycytidine

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Bcl-x(L) antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900002-X

7 January 2021

10.1016/S1368-7646(02)00002-X

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12127861