(Q34755147)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

0 references

1 reference

1 reference

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Magdalena B Flak

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Iain A McNeish

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Claire M Connell

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Laura A Tookman

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Kyra M Archibald

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Katrina J Pirlo

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Michelle Lockley

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Sally P Wheatley

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

language of work or name

English

0 references

publication date

7 March 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

24 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

121

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

1283-1297

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

24 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3069766/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer

7 July 2018

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p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker

7 July 2018

1 reference

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Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

7 July 2018

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Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication

7 July 2018

1 reference

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Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection

7 July 2018

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Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

7 July 2018

1 reference

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Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1.

7 July 2018

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A role for E1B-AP5 in ATR signaling pathways during adenovirus infection

7 July 2018

1 reference

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Homologous recombination in DNA repair and DNA damage tolerance

7 July 2018

1 reference

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Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer

7 July 2018

1 reference

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Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation

7 July 2018

1 reference

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E1B55K-deleted adenovirus (ONYX-015) overrides G1/S and G2/M checkpoints and causes mitotic catastrophe and endoreduplication in p53-proficient normal cells

7 July 2018

1 reference

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Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study

7 July 2018

1 reference

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Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks

7 July 2018

1 reference

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

7 July 2018

1 reference

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

7 July 2018

1 reference

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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

7 July 2018

1 reference

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Cell cycle genes in ovarian cancer: steps toward earlier diagnosis and novel therapies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Cellular checkpoint mechanisms monitoring proper initiation of DNA replication

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Structural basis for Chk1 inhibition by UCN-01

7 July 2018

1 reference

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The RB and p53 pathways in cancer

7 July 2018

1 reference

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Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery

7 July 2018

1 reference

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

7 July 2018

1 reference

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Regulation of the Cdc25A gene by the human papillomavirus Type 16 E7 oncogene

7 July 2018

1 reference

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DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells

7 July 2018

1 reference

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Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

7 July 2018

1 reference

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Rapid destruction of human Cdc25A in response to DNA damage

7 July 2018

1 reference

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Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Molecular characterization of mitochondrial apoptosis-inducing factor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Analysis of the Rb gene and cyclin-dependent kinase 4 inhibitor genes (p16INK4 and p15INK4B) in human ovarian carcinoma cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Adenovirus-induced alterations of the cell growth cycle: effects of mutations in early regions E2A and E2B

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Alterations to controls of cellular DNA synthesis by adenovirus infection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

The adenovirus type 5 E1A enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all early units in cis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Definition of adenovirus type 5 functions involved in the induction of chromosomal aberrations in human cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: association with nuclear viral inclusions requires the early region 4 34-kilodalton protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

An adenovirus type 5 early gene function regulates expression of other early viral genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Nuclear survivin abrogates multiple cell cycle checkpoints and enhances viral oncolysis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Cytometric assessment of histone H2AX phosphorylation: a reporter of DNA damage

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: comparison with E1A wild-type viruses, bioluminescence monitoring, and intraperitoneal delivery in icodextrin.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

S-phase induction by adenovirus E1A requires activation of cdc25a tyrosine phosphatase.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069766

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21383502

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI43976

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383502%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

21383502

1 reference