(Q34786946)

4 August 2017

1 reference

title

Mechanisms of transplant tolerance induction using costimulatory blockade (English)

1 reference

4 August 2017

Thomas Wekerle

1

1 reference

4 August 2017

Josef Kurtz

2

1 reference

4 August 2017

Sinda Bigenzahn

3

1 reference

4 August 2017

Yasuo Takeuchi

4

1 reference

4 August 2017

Megan Sykes

5

1 reference

4 August 2017

publication date

1 October 2002

1 reference

Current Opinion in Immunology

4 August 2017

published in

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4 August 2017

volume

14

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4 August 2017

issue

5

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4 August 2017

page(s)

592-600

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The role of T-cell costimulatory activation pathways in transplant rejection

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Activation of Transplant Immunity: Effect of Donor Leukocytes on Thyroid Allograft Rejection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

The origin and mechanism of the allograft reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CTLA-4 is a second receptor for the B cell activation antigen B7

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Induction of T cell anergy in the absence of CTLA-4/B7 interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CTLA-4 is not required for induction of CD8(+) T cell anergy in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CD152 ligation by CD80 on T cells is required for the induction of unresponsiveness by costimulation-deficient antigen presentation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Skin allograft maintenance in a new synchimeric model system of tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response to Nippostrongylus brasiliensis.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CTLA4Ig-induced linked regulation of allogeneic T cell responses

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Anergic T cells inhibit the antigen-presenting function of dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28−/− mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CTLA4ig induces long-term graft survival of allogeneic skin grafts and totally inhibits T-cell proliferation in LFA-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

CD28-independent costimulation of T cells in alloimmune responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Mixed chimerism and transplantation tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Importance of intrathymic mixed chimerism for the maintenance of skin allograft tolerance across fully allogeneic antigens in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Role of peripheral clonal deletion in tolerance induction with bone marrow transplantation and costimulatory blockade

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4+ cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Superantigens: just like peptides only different

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

T cell death and transplantation tolerance.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Allogeneic chimerism with low-dose irradiation, antigen presensitization, and costimulator blockade in H-2 mismatched mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Mixed chimerism and transplant tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

An essential role for gp39, the ligand for CD40, in thymic selection.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Inability to induce tolerance through direct antigen presentation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2802%2900378-3

7 January 2021

10.1016/S0952-7915(02)00378-3

Identifiers

DOI

1 reference

4 August 2017

1 reference