(Q34786982)

4 August 2017

title

Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation (English)

1 reference

4 August 2017

John R Engen

5

0 references

author name string

Kittichoat Tiyanont

1

1 reference

4 August 2017

Thomas E Wales

2

1 reference

4 August 2017

Miguel Aste-Amezaga

3

1 reference

4 August 2017

Jon C Aster

4

1 reference

4 August 2017

Stephen C Blacklow

6

1 reference

4 August 2017

publication date

1 April 2011

1 reference

4 August 2017

1 reference

4 August 2017

volume

19

1 reference

4 August 2017

issue

4

1 reference

4 August 2017

page(s)

546-554

1 reference

Therapeutic antibody targeting of individual Notch receptors

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

The canonical Notch signaling pathway: unfolding the activation mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Conformational disturbance in Abl kinase upon mutation and deregulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Rational targeting of Notch signaling in cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

High-speed and high-resolution UPLC separation at zero degrees Celsius

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Structural basis for autoinhibition of Notch

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Notch signaling in cancer.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Semi-automated data processing of hydrogen exchange mass spectra using HX-Express

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Notch signalling: a simple pathway becomes complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Hydrogen exchange mass spectrometry for the analysis of protein dynamics

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Calcium depletion dissociates and activates heterodimeric notch receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

The Notch1 receptor is cleaved constitutively by a furin-like convertase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075624

Protein folding and calcium binding defects arising from familial hypercholesterolemia mutations of the LDL receptor

8 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21481777

12 December 2020

inferred from PubMed ID database lookup

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21481777

12 December 2020

inferred from PubMed ID database lookup

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21481777

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.STR.2011.01.016

1 reference

release_i4ck3g3v35gkfiiurynxeyztfa

4 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/i4ck3g3v35gkfiiurynxeyztfa

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3075624

1 reference

4 August 2017

1 reference