(Q34792522)

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Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models.

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20066470%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20066470%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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10

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16 January 2020

author name string

Andries M Bergman

1

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16 January 2020

Auke D Adema

2

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16 January 2020

Jan Balzarini

3

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16 January 2020

Skjalg Bruheim

4

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16 January 2020

Iduna Fichtner

5

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16 January 2020

Paul Noordhuis

6

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16 January 2020

Oystein Fodstad

7

1 reference

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16 January 2020

Finn Myhren

8

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16 January 2020

Marit L Sandvold

9

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16 January 2020

Godefridus J Peters

11

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16 January 2020

publication date

12 January 2010

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16 January 2020

Investigational New Drugs

1 reference

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16 January 2020

29

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16 January 2020

3

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16 January 2020

456-466

1 reference

Europe PubMed Central

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16 January 2020

https://scigraph.springernature.com/pub.10.1007/s10637-009-9377-7

0 references

Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Physiological and pharmacological roles of nucleoside transporter proteins

1 reference

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8 July 2018

Systemic chemotherapy for advanced non-small cell lung cancer: recent advances and future directions.

1 reference

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8 July 2018

Chemotherapy for pancreatic cancer: from metastatic disease to adjuvant therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

The NCI60 human tumour cell line anticancer drug screen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Prolonged fixed dose rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin

1 reference

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8 July 2018

Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

New applications of gemcitabine and future directions in the management of pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Nucleoside and nucleobase transport systems of mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

2',2'-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Development and molecular characterization of a 2',2'-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

The treatment of acute myelogenous leukemia in adults.

1 reference

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8 July 2018

Conditions controlling long-term proliferation of Brown Norway rat promyelocytic leukemia in vitro: primary growth stimulation by microenvironment and establishment of an autonomous Brown Norway 'leukemic stem cell line'.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Kinetics and substrate specificity of human and canine cytidine deaminase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Biochemical and molecular properties of cisplatin-resistant A2780 cells grown in folinic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

New colorimetric cytotoxicity assay for anticancer-drug screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Effects of 1-beta-D-arabinofuranosylcytosine on DNA replication intermediates monitored by pH-step alkaline elution.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

8 July 2018

Intravenous administration of CP-4055 (ELACYT) in patients with solid tumours. A Phase I study

1 reference

https://api.crossref.org/works/10.1007%2FS10637-009-9377-7

21 January 2018

In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant

1 reference

https://api.crossref.org/works/10.1007%2FS10637-009-9377-7

21 January 2018

Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-009-9377-7

21 January 2018

Anti-tumor efficacy of the nucleoside analog 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl) cytosine (4'-thio-FAC) in human pancreatic and ovarian tumor xenograft models

1 reference

https://api.crossref.org/works/10.1007%2FS10637-009-9377-7

21 January 2018

In vitro activity of liposomal N4octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC), a new lipophilic derivative of 1-beta-D-arabinofuranocylcytosine on biopsized clonogenic human tumor cells and hematopoietic precursor cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-009-9377-7

21 January 2018

Anticancer drug delivery systems: multi-loaded N4-acyl poly(ethylene glycol) prodrugs of ara-C. II. Efficacy in ascites and solid tumors

1 reference

https://api.crossref.org/works/10.1007%2FS10637-009-9377-7

21 January 2018

CP-4055 and CP-4126 are active in ara-C and gemcitabine-resistant lymphoma cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS10637-009-9377-7

21 January 2018

Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076580

26 October 2018

Sensitivity of acute leukemia cells to cytarabine is a correlate of cellular es nucleoside transporter site content measured by flow cytometry with SAENTA-fluorescein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20066470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models

1 reference

https://pubmed.ncbi.nlm.nih.gov/20066470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of subclones of L1210 murine leukemia with different sensitivities to various cytotoxic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/20066470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20066470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic studies on 2',2'-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20066470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/20066470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular effects of 2',2'-difluorodeoxycytidine (Gemcitabine) on DNA replication in intact HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20066470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of prolonged as compared with bolus administration of 2',2'-difluorodeoxycytidine in vivo against murine colon tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20066470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-009-9377-7

1 reference

Europe PubMed Central

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16 January 2020

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1 reference

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16 January 2020

1 reference

Europe PubMed Central

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16 January 2020

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