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CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells
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1 reference
stated in
Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
title
CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
main subject
DNA damage
0 references
author
Karen T Liby
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
author name string
Eun-Hee Kim
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
Chu-Xia Deng
series ordinal
2
1 reference
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Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
Michael B Sporn
series ordinal
3
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Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
publication date
1 March 2011
1 reference
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Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
published in
Cancer Prevention Research
1 reference
stated in
Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
volume
4
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Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
issue
3
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stated in
Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
page(s)
425-434
1 reference
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Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
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Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro-survival Akt and mTOR
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A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin
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Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells
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CDDO-imidazolide mediated inhibition of malignant cell growth in Waldenström macroglobulinemia
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Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer
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The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore
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A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells
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2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer
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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling
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The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia
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Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid.
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Targeting DNA checkpoint kinases in cancer therapy
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Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345
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Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice
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Recent advances in chemoprevention of cancer
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The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.
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The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer
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26 October 2018
The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076712
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26 October 2018
The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.
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26 October 2018
A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production
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26 October 2018
Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages
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retrieved
26 October 2018
Identifiers
DOI
10.1158/1940-6207.CAPR-10-0153
1 reference
stated in
Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
PMC publication ID
3076712
1 reference
stated in
Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
PubMed publication ID
21372041
1 reference
stated in
Europe PubMed Central
PMC publication ID
3076712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21372041%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
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