(Q36675836)

English

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells

scientific article published on May 2008

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scholarly article

1 reference

Europe PubMed Central

15 August 2017

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells (English)

1 reference

Europe PubMed Central

15 August 2017

0 references

apoptotic process

0 references

chronic myeloid leukemia

0 references

1 reference

based on heuristic

inferred from title

Hagop Kantarjian

5

object named as

Hagop Kantarjian

1 reference

Europe PubMed Central

15 August 2017

Marina Konopleva

10

object named as

Marina Konopleva

1 reference

Europe PubMed Central

15 August 2017

Michael Andreeff

9

object named as

Michael Andreeff

1 reference

Europe PubMed Central

15 August 2017

3

object named as

Peter Ruvolo

1 reference

Europe PubMed Central

15 August 2017

1

object named as

Ismael Samudio

1 reference

Europe PubMed Central

15 August 2017

4

object named as

Borys Korchin

1 reference

Europe PubMed Central

15 August 2017

Svitlana Kurinna

2

object named as

Svitlana Kurinna

1 reference

Europe PubMed Central

15 August 2017

author name string

Miloslav Beran

6

1 reference

Europe PubMed Central

15 August 2017

Kenneth Dunner

7

1 reference

Europe PubMed Central

15 August 2017

Seiji Kondo

8

1 reference

Europe PubMed Central

15 August 2017

publication date

1 May 2008

1 reference

Europe PubMed Central

15 August 2017

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

15 August 2017

7

1 reference

Europe PubMed Central

15 August 2017

1130-1139

1 reference

Europe PubMed Central

15 August 2017

5

1 reference

Europe PubMed Central

15 August 2017

Flying under the radar: the new wave of BCR-ABL inhibitors

1 reference

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

1 reference

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Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

1 reference

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1 reference

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New strategies in chronic myeloid leukemia

1 reference

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Autophagic programmed cell death by selective catalase degradation

1 reference

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A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

1 reference

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2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer

1 reference

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1 reference

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BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells.

1 reference

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The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia

1 reference

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Clinical resistance to imatinib: mechanisms and implications

1 reference

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Role of mitochondrial phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an antiapoptotic factor

1 reference

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The two major imatinib resistance mutations E255K and T315I enhance the activity of BCR/ABL fusion kinase.

1 reference

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Identification of heme oxygenase-1 as a novel BCR/ABL-dependent survival factor in chronic myeloid leukemia

1 reference

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Initiation of apoptotic signal by the peroxidation of cardiolipin of mitochondria

1 reference

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The biology of CML blast crisis

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Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid.

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JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

1 reference

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30 September 2017

Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396196

30 September 2017

Redox regulation and signaling lipids in mitochondrial apoptosis

1 reference

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Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid

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Mutation in the ATP-binding pocket of the ABL kinase domain in an STI571-resistant BCR/ABL-positive cell line

1 reference

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Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis

1 reference

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STI571: targeting BCR-ABL as therapy for CML.

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JAK-STAT signaling activated by Abl oncogenes

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CDDO induces apoptosis via the intrinsic pathway in lymphoid cells.

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MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18483301

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18483301

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inferred from PubMed ID database lookup

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18483301

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-07-0553

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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