(Q34796433)

English

Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

13

object named as

Eric Ravussin

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

James A Southers

object named as

James A Southers

15

0 references

David A Griffith

object named as

David A Griffith

1

0 references

author name string

Daniel W Kung

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

William P Esler

3

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Paul A Amor

4

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Scott W Bagley

5

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Carine Beysen

6

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Santos Carvajal-Gonzalez

7

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Shawn D Doran

8

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Chris Limberakis

9

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Alan M Mathiowetz

10

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Kirk McPherson

11

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

David A Price

12

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Gabriele E Sonnenberg

14

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Laurel J Sweet

16

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Scott M Turner

17

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Felix F Vajdos

18

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

language of work or name

0 references

publication date

11 December 2014

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

57

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

24

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

10512-10526

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Stimulation of fat oxidation, but no sustained reduction of hepatic lipids by prolonged pharmacological inhibition of acetyl CoA carboxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Data processing and analysis with the autoPROC toolbox

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Overview of the CCP4 suite and current developments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Lipid-induced insulin resistance: unravelling the mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Acetyl-CoA carboxylase-a as a novel target for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Malonyl-CoA, a key signaling molecule in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Disordered lipid metabolism and the pathogenesis of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Acetyl-coenzyme A carboxylases: versatile targets for drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Scaling and assessment of data quality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

De novo lipogenesis in humans: metabolic and regulatory aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

8 July 2018

Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

26 October 2018

Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

26 October 2018

Liver fat and lipid oxidation in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

26 October 2018

Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

26 October 2018

N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

26 October 2018

ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281100

26 October 2018

Inhibition of acetyl-CoA carboxylase 2 enhances skeletal muscle fatty acid oxidation and improves whole-body glucose homeostasis in db/db mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25423286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo and in vitro metabolism studies on a class III antiarrhythmic agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/25423286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbonyl (phenone) reductase in human liver: structure-activity relationship among substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/25423286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25423286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25423286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25423286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM5016022

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34796433&oldid=1561974002"