(Q34801827)

4 August 2017

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title

Beyond the proteasome: trimming, degradation and generation of MHC class I ligands by auxiliary proteases (English)

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4 August 2017

Doriana Fruci

2

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Loredana Saveanu

object named as

Loredana Saveanu

series ordinal

1

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Peter M van Endert

object named as

Peter van Endert

series ordinal

3

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publication date

1 October 2002

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4 August 2017

number of pages

13

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inferred from page(s)

published in

Molecular Immunology

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4 August 2017

volume

39

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4 August 2017

issue

3-4

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4 August 2017

page(s)

203-215

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Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase

4 August 2017

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26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Substrate selection by transporters associated with antigen processing occurs during peptide binding to TAP.

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7 January 2021

The protease inhibitor, N-acetyl-L-leucyl-L-leucyl-leucyl-L-norleucinal, decreases the pool of major histocompatibility complex class I-binding peptides and inhibits peptide trimming in the endoplasmic reticulum

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7 January 2021

Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide

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7 January 2021

A role for a novel luminal endoplasmic reticulum aminopeptidase in final trimming of 26 S proteasome-generated major histocompatability complex class I antigenic peptides

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7 January 2021

Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel

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7 January 2021

Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells

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7 January 2021

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7 January 2021

Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation

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7 January 2021

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7 January 2021

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7 January 2021

Signal sequences: more than just greasy peptides

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7 January 2021

An endoplasmic reticulum protein implicated in chaperoning peptides to major histocompatibility of class I is an aminopeptidase

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7 January 2021

The specificity of proteasomes: impact on MHC class I processing and presentation of antigens

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7 January 2021

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7 January 2021

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7 January 2021

Destruction of proteins as a creative force

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7 January 2021

Thimet oligopeptidase and the stability of MHC class I epitopes in macrophage cytosol.

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7 January 2021

The rat cim effect: TAP allele-dependent changes in a class I MHC anchor motif and evidence against C-terminal trimming of peptides in the ER

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7 January 2021

Alternative pathways for processing exogenous and endogenous antigens that can generate peptides for MHC class I-restricted presentation

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7 January 2021

The major substrates for TAP in vivo are derived from newly synthesized proteins

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7 January 2021

Degradation of cell proteins and the generation of MHC class I-presented peptides

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7 January 2021

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

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7 January 2021

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling

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7 January 2021

A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors

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7 January 2021

Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase

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7 January 2021

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7 January 2021

Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator

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7 January 2021

ER aminopeptidases generate a unique pool of peptides for MHC class I molecules.

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7 January 2021

The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Thimet oligopeptidase (EC 3.4.24.15), a novel protein on the route of MHC class I antigen presentation

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Trimming of antigenic peptides in an early secretory compartment

1 reference

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7 January 2021

Two Novel Routes of Transporter Associated with Antigen Processing (TAP)-independent Major Histocompatibility Complex Class I Antigen Processing

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Heat shock proteins transfer peptides during antigen processing and CTL priming

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Two new proteases in the MHC class I processing pathway

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Tripeptidyl peptidases: enzymes that count

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7 January 2021

Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries.

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7 January 2021

The peptide-binding motif for the human transporter associated with antigen processing

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Efficiency of MHC class I antigen processing: a quantitative analysis

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Cut and trim: generating MHC class I peptide ligands

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

Proteolysis and class I major histocompatibility complex antigen presentation

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900102-5

7 January 2021

10.1016/S0161-5890(02)00102-5

Identifiers

DOI

1 reference

4 August 2017

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