(Q34810356)

4 August 2017

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title

ATPases as drug targets: learning from their structure (English)

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4 August 2017

Patrick Chène

1

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4 August 2017

publication date

1 September 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

volume

1

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4 August 2017

issue

9

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4 August 2017

page(s)

665-673

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The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

4 August 2017

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Kinesin and dynein superfamily proteins in organelle transport and cell division.

21 January 2018

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AAA proteases: cellular machines for degrading membrane proteins

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ATPase switches controlling DNA replication initiation.

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Structure and function of mismatch repair proteins

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Helicase structure and mechanism

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The vacuolar (H+)-ATPases--nature's most versatile proton pumps

21 January 2018

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An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc

21 January 2018

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Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system

21 January 2018

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Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

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Structural biology in drug design: selective protein kinase inhibitors

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Development of inhibitors for protein tyrosine kinases

21 January 2018

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Tyrosine kinase inhibitors: from rational design to clinical trials

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DNA helicase RepA: cooperative ATPase activity and binding of nucleotides

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Strategies toward the design of novel and selective protein tyrosine kinase inhibitors

21 January 2018

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Chemical and biological evolution of nucleotide-binding protein

21 January 2018

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The P-loop--a common motif in ATP- and GTP-binding proteins

21 January 2018

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The glycine-rich sequence of protein kinases: a multifunctional element

21 January 2018

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Nucleoside triphosphate-binding proteins: different scaffolds to achieve phosphoryl transfer

21 January 2018

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Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs

21 January 2018

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Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase

21 January 2018

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An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins

21 January 2018

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21 January 2018

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The structures of HsIU and the ATP-dependent protease HsIU-HsIV

21 January 2018

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A study into the effects of protein binding on nucleotide conformation

21 January 2018

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Protein recognition of adenylate: an example of a fuzzy recognition template

21 January 2018

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Recognition templates for predicting adenylate-binding sites in proteins

21 January 2018

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When fold is not important: a common structural framework for adenine and AMP binding in 12 unrelated protein families

21 January 2018

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Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

21 January 2018

1 reference

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

21 January 2018

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The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

21 January 2018

1 reference

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

1 reference

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

21 January 2018

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Hsp90 inhibitors as novel cancer chemotherapeutic agents

21 January 2018

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Inhibition of branched-chain alpha-keto acid dehydrogenase kinase and Sln1 yeast histidine kinase by the antifungal antibiotic radicicol

21 January 2018

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21 January 2018

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Facile synthesis of a library of 9-alkyl-8-benzyl-9H-purin-6-ylamine derivatives

21 January 2018

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A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

21 January 2018

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Advances in DNA gyrase inhibitors

21 January 2018

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Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening

21 January 2018

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Inhibitors of kinesin activity from structure-based computer screening

21 January 2018

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

21 January 2018

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A small-molecule inhibitor of skeletal muscle myosin II.

21 January 2018

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The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

21 January 2018

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The proton-pump inhibitors: similarities and differences

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ATPase domain of eukaryotic DNA topoisomerase II. Inhibition of ATPase activity by the anti-cancer drug bisdioxopiperazine and ATP/ADP-induced dimerization

21 January 2018

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X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain

21 January 2018

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Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

21 January 2018

1 reference

Switch-based mechanism of kinesin motors

21 January 2018

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Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules

21 January 2018

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Crystal structure of the kinesin motor domain reveals a structural similarity to myosin

21 January 2018

1 reference

Direction determination in the minus-end-directed kinesin motor ncd

21 January 2018

1 reference

A structural pathway for activation of the kinesin motor ATPase.

21 January 2018

1 reference

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

1 reference

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

21 January 2018

1 reference

The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter

21 January 2018

1 reference

Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter

21 January 2018

1 reference

Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing

21 January 2018

1 reference

DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase

21 January 2018

1 reference

Structure and mechanism of the RuvB Holliday junction branch migration motor

21 January 2018

1 reference

Atomic structure of the clamp loader small subunit from Pyrococcus furiosus

21 January 2018

1 reference

Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein

21 January 2018

1 reference

Structure of the AAA ATPase p97

21 January 2018

1 reference

Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control

21 January 2018

1 reference

Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides

21 January 2018

1 reference

Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis

21 January 2018

1 reference

Structural and functional studies of MinD ATPase: implications for the molecular recognition of the bacterial cell division apparatus.

21 January 2018

1 reference

Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation

21 January 2018

1 reference

The structure of crystalline profilin-beta-actin

21 January 2018

1 reference

Crystal structure of the cell division protein FtsA from Thermotoga maritima

21 January 2018

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In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

21 January 2018

1 reference

Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center

21 January 2018

1 reference

Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair

21 January 2018

1 reference

21 January 2018

The Protein Data Bank

1 reference

21 January 2018

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Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis

21 January 2018

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Structure of Haemophilus influenzae HslU protein in crystals with one-dimensional disorder twinning

21 January 2018

1 reference

The Interaction of Coumarin Antibiotics with Fragments of the DNA Gyrase B Protein†

21 January 2018

1 reference

Structure of a new crystal form of human Hsp70 ATPase domain

21 January 2018

1 reference

Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase.

21 January 2018

1 reference

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD894

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4 August 2017

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