(Q34816461)

4 August 2017

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title

Glutathione, iron and Parkinson's disease (English)

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4 August 2017

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Srinivas Bharath

1

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4 August 2017

Michael Hsu

2

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4 August 2017

Deepinder Kaur

3

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4 August 2017

Subramanian Rajagopalan

4

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4 August 2017

Julie K Andersen

5

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4 August 2017

language of work or name

English

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publication date

1 September 2002

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4 August 2017

published in

Biochemical Pharmacology

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4 August 2017

volume

64

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4 August 2017

issue

5-6

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4 August 2017

page(s)

1037-1048

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Parkinson's disease--redox mechanisms

4 August 2017

cites work

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Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

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S-nitrosylation and S-glutathiolation of protein sulfhydryls by S-nitroso glutathione

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Glutathione in health and disease: pharmacotherapeutic issues

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Glutathione synthesis is essential for mouse development but not for cell growth in culture

7 January 2021

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Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

7 January 2021

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Alterations in mitochondrial membrane fluidity by lipid peroxidation products

7 January 2021

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7 January 2021

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Reactive oxygen species and the central nervous system

7 January 2021

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GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter

7 January 2021

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Cellular and regional distribution of reduced glutathione in the nervous system of the rat: histochemical localization by mercury orange and o-phthaldialdehyde-induced histofluorescence

7 January 2021

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Immunocytochemical demonstration of reduced glutathione in neurons of rat forebrain

7 January 2021

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Increased intra- and extracellular concentrations of gamma-glutamylglutamate and related dipeptides in the ischemic rat striatum: involvement of glutamyl transpeptidase

7 January 2021

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In vivo monitoring of glutathione and cysteine in rat caudate nucleus using microdialysis on-line with capillary zone electrophoresis-laser induced fluorescence detection

7 January 2021

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Determination of extracellular glutathione in rat brain by microdialysis and high-performance liquid chromatography with fluorescence detection

7 January 2021

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Glutathione and signal transduction in the mammalian CNS.

7 January 2021

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Oxidative stress, caloric restriction, and aging

7 January 2021

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The pharmacokinetics and pharmaco-dynamics of Procysteine in amyotrophic lateral sclerosis

7 January 2021

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The effect of aging on glutathione and cysteine levels in different regions of the mouse brain

7 January 2021

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7 January 2021

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Glutathione levels in specific brain regions of genetically epileptic (tg/tg) mice

7 January 2021

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Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

7 January 2021

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Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

7 January 2021

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Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients

7 January 2021

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Effect of buthionine sulfoximine, a synthesis inhibitor of the antioxidant glutathione, on the murine nigrostriatal neurons

7 January 2021

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7 January 2021

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7 January 2021

Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones.

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Reduction of brain glutathione by L-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum

7 January 2021

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Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration

7 January 2021

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Depletion of cytosolic GSH decreases the ATP levels and viability of synaptosomes from aged mice but not from young mice

7 January 2021

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Effects of arachidonic acid on respiratory activities in isolated brain mitochondria

7 January 2021

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Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

7 January 2021

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Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease

7 January 2021

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Mitochondrial complex I defects in aging.

7 January 2021

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Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration.

7 January 2021

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Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

7 January 2021

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Superoxide accelerates DNA damage by elevating free-iron levels

7 January 2021

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Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation

7 January 2021

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Glutathione depletion and formation of glutathione-protein mixed disulfide following exposure of brain mitochondria to oxidative stress

7 January 2021

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An improved HPLC-electrochemical detection method for measuring brain levels of 5-S-cysteinyldopamine, 5-S-cysteinyl-3,4-dihydroxyphenylalanine, and 5-S-cysteinyl-3,4-dihydroxyphenylacetic acid

7 January 2021

1 reference

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Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

7 January 2021

1 reference

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Thiol oxidation and loss of mitochondrial complex I precede excitatory amino acid-mediated neurodegeneration.

7 January 2021

1 reference

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The role of iron-sulfur clusters in in vivo hydroxyl radical production

7 January 2021

1 reference

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Reduced intravenous glutathione in the treatment of early Parkinson's disease

7 January 2021

1 reference

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Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: a neurochemical and morphological reassessment

7 January 2021

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

7 January 2021

1 reference

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Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

7 January 2021

1 reference

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Formation of superoxide and hydroxyl radicals from 1-methyl-4-phenylpyridinium ion (MPP+): reductive activation by NADPH cytochrome P-450 reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Chemically induced Parkinson's disease: intermediates in the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the 1-methyl-4-phenyl-pyridinium ion

7 January 2021

1 reference

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MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes.

7 January 2021

1 reference

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The importance of free radicals and catalytic metal ions in human diseases

7 January 2021

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The possible relation of glutathione, melanin and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) to Parkinson's disease

7 January 2021

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What causes the build-up of ubiquitin-containing inclusions in Parkinson's disease?

7 January 2021

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The ubiquitin pathway in Parkinson's disease

7 January 2021

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The genetics of Parkinson's disease

7 January 2021

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Genetics of Parkinson's disease

7 January 2021

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7 January 2021

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Genetics of Parkinson's disease

7 January 2021

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Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease?

7 January 2021

1 reference

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

7 January 2021

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Glutathione decreases in dopaminergic PC12 cells interfere with the ubiquitin protein degradation pathway: relevance for Parkinson's disease?

7 January 2021

1 reference

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MPTP- and MPP(+)-induced effects on body temperature exhibit age- and strain-dependence in mice

7 January 2021

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Irreversible inhibition of mitochondrial complex I by 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1): a putative nigral endotoxin of relevance to Parkinson's disease.

7 January 2021

1 reference

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Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

7 January 2021

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Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

7 January 2021

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Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

7 January 2021

1 reference

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Iron in the basal ganglia in Parkinson's disease. An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy

7 January 2021

1 reference

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Distribution of iron in different brain regions and subcellular compartments in Parkinson's disease

7 January 2021

1 reference

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Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography

7 January 2021

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Vulnerability of the nigrostriatal system as detected by transcranial ultrasound

7 January 2021

1 reference

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Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease

7 January 2021

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MRI evaluation of brain iron in earlier- and later-onset Parkinson's disease and normal subjects

7 January 2021

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Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease

7 January 2021

1 reference

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Decreased ferritin levels in brain in Parkinson's disease

7 January 2021

1 reference

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Brain iron and ferritin in Parkinson's and Alzheimer's diseases.

7 January 2021

1 reference

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Complex I, iron, and ferritin in Parkinson's disease substantia nigra

7 January 2021

1 reference

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In vitro studies of ferritin iron release and neurotoxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Dopamine Neurotoxicity: Inhibition of Mitochondrial Respiration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.

7 January 2021

1 reference

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Iron-melanin interaction and lipid peroxidation: implications for Parkinson's disease

7 January 2021

1 reference

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The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method

7 January 2021

1 reference

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Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Preservation of midbrain catecholaminergic neurons in very old human subjects

7 January 2021

1 reference

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Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease

7 January 2021

1 reference

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Possible role of neuromelanin in the pathogenesis of Parkinson's disease

7 January 2021

1 reference

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Intranigral iron injection induces behavioral and biochemical "parkinsonism" in rats

7 January 2021

1 reference

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Nature of inhibition of mitochondrial respiratory complex I by 6-Hydroxydopamine

7 January 2021

1 reference

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6-Hydroxydopamine releases iron from ferritin and promotes ferritin-dependent lipid peroxidation

7 January 2021

1 reference

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The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons

7 January 2021

1 reference

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Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

7 January 2021

1 reference

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Iron and neurodegenerative disorders

7 January 2021

1 reference

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Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: a nuclear microscopy study

7 January 2021

1 reference

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Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Copper(II)-induced self-oligomerization of alpha-synuclein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Glutathione, oxidative stress and neurodegeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: effect of R-apomorphine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

Neuropathology of Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

7 January 2021

Gamma-glutamyl transpeptidase, a blood-brain barrier associated membrane protein. Splitting peptides to transport amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

7 January 2021

Altered brain metabolism of iron as a cause of neurodegenerative diseases?

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

7 January 2021

Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901174-7

7 January 2021

10.1016/S0006-2952(02)01174-7

Identifiers

DOI

1 reference

4 August 2017

1 reference