(Q34818240)

4 August 2017

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title

The Nek2 protein kinase: a novel regulator of centrosome structure (English)

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Cell-cycle regulated serine/threonine protein kinase

4 August 2017

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Andrew M Fry

1

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language of work or name

English

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publication date

1 September 2002

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4 August 2017

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4 August 2017

21

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4 August 2017

6184-6194

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4 August 2017

40

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205711

4 August 2017

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cites work

Chromosomal passengers and the (aurora) ABCs of mitosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Re-evaluating centrosome function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

The spindle pole body of Saccharomyces cerevisiae: architecture and assembly of the core components

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Regulating centrosomes by protein phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Cell cycle. The NIMA kinase joins forces with Cdc2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Nek2 expression and localization in porcine oocyte during maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Comparative structural, molecular, and functional aspects of the Dictyostelium discoideum centrosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

The microtubule organizing centers of Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

"It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

The transcriptional program in the response of human fibroblasts to serum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

The mammalian interphase centrosome: two independent units maintained together by the dynamics of the microtubule cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Isolation of a novel protein kinase-encoding gene from yeast by oligodeoxyribonucleotide probing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Evidence for a NIMA-like mitotic pathway in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Protein kinases in control of the centrosome cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Mitotic kinases as regulators of cell division and its checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Cell cycle regulation in Aspergillus by two protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Isolation of a functional homolog of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans and functional analysis of conserved residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Waiting for anaphase: Mad2 and the spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

The in vivo expression pattern of mouse Nek2, a NIMA-related kinase, indicates a role in both mitosis and meiosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Two structural variants of Nek2 kinase, termed Nek2A and Nek2B, are differentially expressed in Xenopus tissues and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Nek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Regulation and regulatory activities of centrosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

A role for NIMA in the nuclear localization of cyclin B in Aspergillus nidulans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Regulation of the anaphase-promoting complex/cyclosome by bimAAPC3 and proteolysis of NIMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

Supernumerary centrosomes and cancer: Boveri's hypothesis resurrected

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

7 January 2021

Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

7 January 2021

Identification of centrosome kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

7 January 2021

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

7 January 2021

Premature chromatin condensation upon accumulation of NIMA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

7 January 2021

Centrosome organization and centriole architecture: their sensitivity to divalent cations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

7 January 2021

NPK1, a nonessential protein kinase gene in Saccharomyces cerevisiae with similarity to Aspergillus nidulans nimA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

7 January 2021

Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205711

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205711

1 reference

PubMed ID

12214248

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12214248