(Q34831383)

4 August 2017

title

In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability (English)

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4 August 2017

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12

Ken A Dill

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4 August 2017

3

Bruce Kabakoff

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4 August 2017

2

Thomas W Patapoff

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4 August 2017

10

Ilya Chorny

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4 August 2017

Vikas K Sharma

1

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4 August 2017

Satyan Pai

4

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4 August 2017

Eric Hilario

5

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4 August 2017

Boyan Zhang

6

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4 August 2017

Charlene Li

7

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4 August 2017

Oleg Borisov

8

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4 August 2017

Robert F Kelley

9

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4 August 2017

Joe Z Zhou

11

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4 August 2017

Trevor E Swartz

13

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4 August 2017

language of work or name

English

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publication date

15 December 2014

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Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

published in

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4 August 2017

volume

111

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4 August 2017

issue

52

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4 August 2017

page(s)

18601-18606

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Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284567

Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284567

Weak interactions govern the viscosity of concentrated antibody solutions: high-throughput analysis using the diffusion interaction parameter

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284567

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284567

Design of therapeutic proteins with enhanced stability.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284567

Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284567

The CCP4 suite: programs for protein crystallography

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284567

Challenges in the development of high protein concentration formulations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284567

Comparative protein modelling by satisfaction of spatial restraints

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284567

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4284567

Concentration dependent viscosity of monoclonal antibody solutions: explaining experimental behavior in terms of molecular properties.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

A strategy for risk mitigation of antibodies with fast clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

Reduced elimination of IgG antibodies by engineering the variable region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: mechanisms and stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

Aspartate isomerization in the complementarity-determining regions of two closely related monoclonal antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

Neighboring side chain effects on asparaginyl and aspartyl degradation: an ab initio study of the relationship between peptide conformation and backbone NH acidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

Isomerization of Asp-Asp motif in model peptides and a monoclonal antibody Fab fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1421779112

Entanglement model of antibody viscosity

21 January 2018

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12 December 2020

Hydrophobic salts markedly diminish viscosity of concentrated protein solutions

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12 December 2020

Something new under the skin

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12 December 2020

Full correlation analysis of conformational protein dynamics

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12 December 2020

Computational methods to predict therapeutic protein aggregation

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12 December 2020

Accurate determination of succinimide degradation products using high fidelity trypsin digestion peptide map analysis

1 reference

12 December 2020

Monoclonal antibody pharmacokinetics and pharmacodynamics

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12 December 2020

Specific interactions in high concentration antibody solutions resulting in high viscosity

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1421779112

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4 August 2017

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4 August 2017

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