(Q34836887)

4 August 2017

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title

Ontogeny of hepatic and renal systemic clearance pathways in infants: part I. (English)

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4 August 2017

Jane Alcorn

1

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4 August 2017

Patrick J McNamara

series ordinal

2

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4 August 2017

publication date

1 January 2002

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Clinical Pharmacokinetics

4 August 2017

published in

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4 August 2017

volume

41

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4 August 2017

issue

12

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4 August 2017

page(s)

959-998

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Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part I).

4 August 2017

cites work

1 reference

12 December 2020

Structure and expression of the human MDR (P-glycoprotein) gene family

1 reference

12 December 2020

Theophylline metabolism during the first month of life and development

1 reference

12 December 2020

Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes

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12 December 2020

Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part II).

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12 December 2020

Development of mechanisms for drug excretion

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12 December 2020

Tissue and species differences in enzymes of epoxide metabolism

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12 December 2020

Organ distribution of glutathione transferase isoenzymes in the human fetus: differences between liver and extrahepatic tissues

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12 December 2020

Enzyme induction in neonates after fetal exposure to antiepileptic drugs

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12 December 2020

Pharmacokinetics of orally administered furosemide

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12 December 2020

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

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12 December 2020

Development of enzymic zonation in liver parenchyma is related to development of acinar architecture

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12 December 2020

Polymorphic acetylation of 7-amino-clonazepam in human liver cytosol

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12 December 2020

Fetal and neonatal hepatic perfusion and oxygenation.

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12 December 2020

Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man

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12 December 2020

Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene

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12 December 2020

Elimination of indocyanine green by the liver of infants with hypertrophic pyloric stenosis and the icteropyloric syndrome

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12 December 2020

Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes.

1 reference

12 December 2020

Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus

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12 December 2020

MATURATION OF RENAL FUNCTION IN CHILDHOOD: CLEARANCE STUDIES.

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12 December 2020

Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver

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12 December 2020

Effect of maturation on drug disposition in pediatric patients

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12 December 2020

Expression of CYP2E1 during human fetal development: methylation of the CYP2E1 gene in human fetal and adult liver samples

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12 December 2020

Hepatic drug clearance in children with leukemia: changes in clearance of model substrates during remission-induction therapy

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12 December 2020

UDP-glucuronosyltransferase activity in human liver and colon

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12 December 2020

The Maturation of Morphine Clearance and Metabolism

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12 December 2020

The regulation of liver development by birth.

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12 December 2020

Developmental changes in the regional Na+/glucose transporter mRNA along the small intestine of suckling rats.

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12 December 2020

Developmental Aspects of Drug Conjugation, with Special Reference to Glucuronidation

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12 December 2020

Correlation between fluid reabsorption and proximal tubule ultrastructure during development of the rat kidney

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12 December 2020

Maturation of renal function in full-term and premature neonates

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12 December 2020

Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes

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12 December 2020

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

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12 December 2020

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

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12 December 2020

Postnatal development of bile secretory physiology in the dog

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12 December 2020

Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake

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12 December 2020

Immaturity of hepatic excretory function and the ontogeny of bile acid metabolism

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12 December 2020

Changes in urinary 6beta-hydroxycortisol/cortisol ratio after birth in human neonates.

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12 December 2020

Maturation and growth of renal function: dosing renally cleared drugs in children

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12 December 2020

Foreign compound metabolism studies with human liver obtained as surgical waste. Relation to donor characteristics and effects of tissue storage

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12 December 2020

Sulphation of N-hydroxy-4-aminobiphenyl and N-hydroxy-4-acetylaminobiphenyl by human foetal and neonatal sulphotransferase

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12 December 2020

Vancomycin pharmacokinetics in neonates receiving extracorporeal membrane oxygenation.

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12 December 2020

Bile secretion and its control in the newborn puppy

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12 December 2020

Expression of CYP2D6 in developing human liver

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12 December 2020

Renal clearance of digoxin in premature neonates

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12 December 2020

Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults

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12 December 2020

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

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12 December 2020

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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12 December 2020

A simple method for the estimation of glomerular filtration rate by gentamicin pharmacokinetics during routine drug monitoring in the newborn.

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12 December 2020

Glutathione s-transferase activity in rat and human tissues and organs

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12 December 2020

Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth

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12 December 2020

Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.

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12 December 2020

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini

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12 December 2020

Biotransformation of xenobiotics in the fetus

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12 December 2020

Development of human liver UDP-glucuronosyltransferases.

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12 December 2020

Sulfotransferase in humans: development and tissue distribution

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12 December 2020

Differential localisation of UDP-glucuronosyltransferase in kidney during human embryonic and fetal development

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12 December 2020

Nomenclature for human CYP2D6 alleles.

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12 December 2020

Developmental expression of P-glycoprotein (multidrug resistance gene product) in the rat brain

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12 December 2020

Gentamicin monitoring in neonates

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12 December 2020

Netilmicin in the neonate: population pharmacokinetic analysis and dosing recommendations

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12 December 2020

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

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12 December 2020

CHANGES IN THE LIVER CIRCULATION AT BIRTH

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12 December 2020

Inhibition of human term placental and fetal liver glutathione-S-transferases by fatty acids and fatty acid esters

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12 December 2020

Phenotyping of drug metabolism in infants and children: potentials and problems

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12 December 2020

Two distinct forms of glutathione transferase from human foetal liver. Purification and comparison with isoenzymes isolated from adult liver and placenta

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12 December 2020

Expression and inducibility of P450 enzymes during liver ontogeny

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12 December 2020

Biochemistry and molecular biology of the human CYP2C subfamily

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12 December 2020

Differential distribution of phenol and catechol sulphotransferases in human liver and intestinal mucosa

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12 December 2020

Isolation of a new human fetal liver cytochrome P450 cDNA clone: evidence for expression of a limited number of forms of cytochrome P450 in human fetal livers

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12 December 2020

Expressing glomerular filtration rate in children

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12 December 2020

The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes.

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12 December 2020

The development expression of alpha-, mu- and pi-class glutathione S-transferases in human liver.

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12 December 2020

Clinical pharmacology of midazolam in infants and children

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12 December 2020

Oxidative and reductive metabolism by cytochrome P450 2E1.

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12 December 2020

The development in the human liver of multiple desoxyribose nucleic acid (DNA) classes and their relationship to the age of the individual

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12 December 2020

Glutathione S-transferase in humans: development and tissue distribution

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12 December 2020

Developmental aspects of the hepatic cytochrome P450 monooxygenase system

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12 December 2020

Morphine glucuronidation in human fetal and adult liver

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12 December 2020

In vivo N7 methylation of theophylline to caffeine in premature infants. Studies with use of stable isotopes

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12 December 2020

The establishment of hepatocyte cell surface polarity during fetal liver development

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12 December 2020

Ultrasonographic measurement of the human fetal liver in utero

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12 December 2020

Glutathione-S-transferase in human fetal liver

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12 December 2020

Uptake of ouabain by isolated hepatocytes from livers of developing rats

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12 December 2020

Drug use in the neonate: interrelationships of pharmacokinetics, toxicity, and biochemical maturity.

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12 December 2020

Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

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12 December 2020

Pharmacokinetics of intravenous omeprazole in children

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12 December 2020

Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA

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12 December 2020

A short review of perinatal pharmacology

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12 December 2020

Glomerular filtration rate, effective renal blood flow, and maximal tubular excretory capacity in infancy

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12 December 2020

The expression of xenobiotic-metabolizing cytochromes P450 in fetal tissues

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12 December 2020

Quantitative measurements of the urinary excretion of creatinine, uric acid, hypoxanthine and xanthine, uracil, cyclic AMP, and cyclic GMP in healthy newborn infants

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12 December 2020

Serum creatinine and creatinine clearance in healthy neonates and prematures during the first 10 days of life

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12 December 2020

Pharmacokinetics of antibiotics in neonates

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12 December 2020

Fetus-specific expression of a form of cytochrome P-450 in human livers

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12 December 2020

Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis

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12 December 2020

The ontogeny of key endoplasmic reticulum proteins in human embryonic and fetal red blood cells.

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12 December 2020

Ontogeny of hepatic and renal systemic clearance pathways in infants: part II.

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12 December 2020

Neonatal hepatic drug elimination

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12 December 2020

Glutathione transferases--structure and catalytic activity

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12 December 2020

Dopamine sulphotransferase is better developed than p-nitrophenol sulphotransferase in the human fetus

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12 December 2020

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16

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12 December 2020

Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics

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12 December 2020

Vancomycin pharmacokinetics in infants undergoing extracorporeal membrane oxygenation

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12 December 2020

Simultaneous administration of multiple model substrates to assess hepatic drug clearance.

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12 December 2020

Hepatocyte heterogeneity in bile formation and hepatobiliary transport of drugs

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12 December 2020

Pharmacokinetics and administration regimens of vancomycin in neonates, infants and children

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12 December 2020

Transcriptional control of the rat hepatic CYP2E1 gene

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12 December 2020

Clinical pharmacokinetics in infants and children. A reappraisal

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12 December 2020

The late intrauterine and postnatal development of human renal glomeruli

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12 December 2020

Clinical pharmacology of the perinatal period and early infancy

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12 December 2020

Fetal hemopoiesis. II. Electron microscopic studies on human hepatic hemopoiesis

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12 December 2020

Characteristics of hepatic excretory function during development

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12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

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12 December 2020

Development of the glucuronyltransferase and sulphotransferase towards 2-naphthol in human fetus.

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12 December 2020

Renal hemodynamics and functional changes during the transition from fetal to newborn life in sheep.

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12 December 2020

Therapeutic drug monitoring in the neonate and paediatric age group. Problems and clinical pharmacokinetic implications

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12 December 2020

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

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12 December 2020

Human liver phenol sulfotransferase: assay conditions, biochemical properties and partial purification of isozymes of the thermostable form

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12 December 2020

Enzyme induction in the cytochrome P-450 system

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12 December 2020

Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion

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12 December 2020

Fetal drug metabolism and its possible clinical implications

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12 December 2020

Effect of phenobarbital administration on theophylline clearance in premature neonates.

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12 December 2020

Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18

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12 December 2020

The population pharmacokinetics of theophylline in neonates and young infants

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12 December 2020

Glucuronidation in humans. Pharmacogenetic and developmental aspects

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12 December 2020

INTRAHEPATIC VASCULAR PATTERN IN THE NEWBORN INFANT

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12 December 2020

Fetal hepatic drug elimination

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12 December 2020

The role of therapeutic drug monitoring in children

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12 December 2020

Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain

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12 December 2020

Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

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12 December 2020

The use of caffeine as a metabolic probe for human drug metabolizing enzymes

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12 December 2020

Hepatocellular transport systems: from carrier identification in membrane vesicles to cloned proteins

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12 December 2020

Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?

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12 December 2020

Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

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12 December 2020

Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers

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12 December 2020

The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver.

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12 December 2020

Developmental changes in renal artery blood flow velocity during the first three weeks of life in preterm neonates.

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12 December 2020

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

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12 December 2020

Advances in hepatic transport: molecular mechanisms, genetic disorders, and treatment. A summary of the 1998 AASLD single topic conference

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12 December 2020

Prenatal and neonatal drug metabolism in man

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12 December 2020

Purification of a new glutathione S-transferase (transferase mu) from human liver having high activity with benzo(alpha)pyrene-4,5-oxide

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12 December 2020

Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome P450 enzymes

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12 December 2020

Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver

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12 December 2020

Cellular development of some human organs before birth

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12 December 2020

Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age

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12 December 2020

Developmental patterns of renal functional maturation compared in the human neonate

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12 December 2020

Renal function as a marker of human fetal maturation

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12 December 2020

Development of human polymorphic N-acetyltransferase

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12 December 2020

Pharmacokinetic and pharmacodynamic study of midazolam in children during esophagogastroduodenoscopy.

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12 December 2020

Glutathione S-transferases in neonatal liver disease

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12 December 2020

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

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12 December 2020

Constitutive expression of hepatic cytochrome P450 genes

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12 December 2020

Population pharmacokinetics of midazolam in neonates.

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12 December 2020

Pharmacology of furosemide in the premature newborn infant

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12 December 2020

Nomenclature for human glutathione transferases

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12 December 2020

Adverse drug reactions from birth to early childhood

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12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Comparison of methods of measuring renal function in preterm babies using inulin

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12 December 2020

Drug acetylator phenotypes in newborn infants.

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12 December 2020

Fatal cardiovascular collapse of infants receiving large amounts of chloramphenicol

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12 December 2020

Pharmacokinetics of lorazepam in critically ill neonates with seizures

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12 December 2020

Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients.

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12 December 2020

Pharmacokinetic and pharmacodynamic data collection in children and neonates. A quiet frontier

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12 December 2020

A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy

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12 December 2020

Onset of xenobiotic metabolism in children: toxicological implications

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12 December 2020

Interactions of drugs with the developing kidney.

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12 December 2020

Dosage guidelines for the use of vancomycin based on its pharmacokinetics in infants

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12 December 2020

Cytochrome P450-dependent metabolism of dextromethorphan: fetal and adult studies

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12 December 2020

Prediction of glomerular filtration rate using aminoglycoside clearance in critically ill medical patients

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12 December 2020

Developmental factors influencing interactions of drugs

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12 December 2020

Clinical appraisal of creatinine clearance as a measurement of glomerular filtration rate

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12 December 2020

The human glutathione S-transferases: developmental aspects of the GST1, GST2, and GST3 loci.

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12 December 2020

Zidovudine pharmacokinetics in premature infants exposed to human immunodeficiency virus

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12 December 2020

Sulphation and glucuronidation of ritodrine in human foetal and adult tissues

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12 December 2020

Differential expression and regulation of members of the cytochrome P450IA gene subfamily in human tissues

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12 December 2020

Cytochrome P450 in human fetal liver: significance and fetal-specific expression

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12 December 2020

Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation

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12 December 2020

Glutathione S-transferase activity in human fetal and adult tissues

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12 December 2020

Development of renal function in fetal and neo-natal rabbits using phenolsulfonphthalein

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12 December 2020

Glomerular filtration rate during the period of adaptation to extrauterine life

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12 December 2020

Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant

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12 December 2020

DEVELOPMENT OF THE HUMAN GLOMERULUS

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12 December 2020

Phase I evaluation of zidovudine administered to infants exposed at birth to the human immunodeficiency virus

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12 December 2020

Hepatic drug clearance in children: studies with indocyanine green as a model substrate

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12 December 2020

Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

12 December 2020

Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide

1 reference

12 December 2020

Changes in vancomycin pharmacokinetics in critically ill infants

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12 December 2020

Serum creatinine concentration, urinary creatinine excretion and creatinine clearance during the first 9 weeks in preterm infants with a birth weight below 1500 g.

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12 December 2020

Metabolism of chloramphenicol by glutathione S-transferase in human fetal and neonatal liver

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12 December 2020

Metabolism during fetal life: a functional assessment of metabolic development

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12 December 2020

A comparison of the ontogeny of enterocytic and hepatic cytochromes P450 3A in the rat

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12 December 2020

Morphine metabolism in children

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12 December 2020

Maturational changes in renal blood flow in piglets

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12 December 2020

Acetaminophen: Potentially Toxic Metabolite Formed by Human Fetal and Adult Liver Microsomes and Isolated Fetal Liver Cells

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12 December 2020

Glomerular filtration rate in the preterm infant: the relation to gestational and postnatal age.

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12 December 2020

Maturational changes in the fetal glomerular filtration rate

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12 December 2020

Postnatal adjustment in renal function.

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12 December 2020

Electron microscopic studies of blood embryogenesis in humans. I. The ultrastructure of the fetal liver

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12 December 2020

Molecular enzymology of human liver cytosolic sulfotransferases

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12 December 2020

Ontogenic expression of the Na(+)-independent organic anion transporting polypeptide (oatp) in rat liver and kidney.

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12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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12 December 2020

The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

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12 December 2020

Development of multiple activities of UDP-glucuronyltransferase in human liver

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12 December 2020

Experimental evidence that the physiological position of the liver within the circulation is not a major determinant of zonation of gene expression

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12 December 2020

Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period

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12 December 2020

Inhibition and induction of cytochrome P450 and the clinical implications

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12 December 2020

Pharmacokinetic observations of phenytoin disposition in the newborn and young infant

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12 December 2020

Perinatal Renal Pharmacology

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12 December 2020

Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity

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12 December 2020

Studies of the development of basic, neutral and acidic isoenzymes of glutathione S-transferase in human liver, adrenal, kidney and spleen

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12 December 2020

Postconceptional age and gentamicin elimination half-life

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12 December 2020

Pharmacokinetics of midazolam in critically ill neonates.

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12 December 2020

Update: genetic polymorphism of drug metabolizing enzymes in humans

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12 December 2020

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

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12 December 2020

Gentamicin dosing and pharmacokinetics in low birth weight infants

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12 December 2020

The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain

1 reference

12 December 2020

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

12 December 2020

Liver and ductus venosus blood flows in fetal lambs in utero

1 reference

12 December 2020

Clearance concepts in pharmacokinetics

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12 December 2020

Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration

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12 December 2020

Factors influencing glomerular filtration rate in the fetal lamb [proceedings]

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12 December 2020

The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes

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12 December 2020

The ethical boundaries of drug research in pediatrics

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12 December 2020

Expression of functional cytochrome P4501A1 in human embryonic hepatic tissues during organogenesis

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12 December 2020

Use of Experimental Models to Study the Development of Renal Function

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12 December 2020

Glutathione S-transferases in relation to their role in the biotransformation of xenobiotics

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12 December 2020

Identification of a polymorphically expressed member of the human cytochrome P-450III family

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12 December 2020

Renal hemodynamics in the perinatal period. A study in lambs

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12 December 2020

Entry of bilirubin into the brain due to opening of the blood-brain barrier.

1 reference

12 December 2020

Developmental changes in renal blood flow velocity.

1 reference

12 December 2020

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme

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12 December 2020

Comparison of renal function in term fetal sheep and newborn lambs

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12 December 2020

In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease

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12 December 2020

POSTNATAL DEVELOPMENT OF ORGANIC CATION TRANSPORT IN THE RAT LIVER

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12 December 2020

Developmental expression of cytochrome P450 enzymes in human liver

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12 December 2020

Alterations in theophylline metabolism during the first year of life

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12 December 2020

Histology of the liver

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12 December 2020

Sulfation of endogenous compounds and xenobiotics--interactions and function in health and disease

1 reference

12 December 2020

Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13

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12 December 2020

Age dependence of hepatic transport in control and phenobarbital-pretreated rats

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12 December 2020

Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family

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12 December 2020

Delayed ontogenesis of CYP1A2 in the human liver

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12 December 2020

Creatinine: an inadequate filtration marker in glomerular diseases

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12 December 2020

Purification and subunit-structural and immunological characterization of five glutathione S-transferases in human liver, and the acidic form as a hepatic tumor marker

1 reference

12 December 2020

Determination of drug metabolizing enzymes in needle biopsies of human liver

1 reference

12 December 2020

Aspects of theophylline clearance in children.

1 reference

12 December 2020

Acetaminophen elimination kinetics in neonates, children, and adults

1 reference

12 December 2020

Hepatic and ductus venosus blood flows during fetal life

1 reference

12 December 2020

Caffeine acetylator phenotyping during maturation in infants

1 reference

12 December 2020

Morphine pharmacokinetics in premature and mature newborn infants

1 reference

12 December 2020

Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes.

1 reference

12 December 2020

Post mortem characteristics of the hepatic microsomal drug oxidising enzyme system

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12 December 2020

The post-mortem diminution of rat liver microsomal protein synthesizing and drug metabolizing activities

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12 December 2020

Bile-salt metabolism in the newborn. Measurement of pool size and synthesis by stable isotope technic

1 reference

12 December 2020

The pharmacokinetics of midazolam in paediatric patients.

1 reference

12 December 2020

Assessment of glomerular filtration rate in preterm infants by serum creatinine: comparison with inulin clearance

1 reference

12 December 2020

Report on the international workshop on the use of human in vitro liver preparations to study drug metabolism in drug development. Held at Utrecht, The Netherlands, 6-8 September 1994.

1 reference

12 December 2020

Estimating glomerular filtration rate in infants

1 reference

12 December 2020

Effect on maturation of kidney function in newborn infants of repeated administration of water and electrolytes

1 reference

12 December 2020

THE GROWTH AND MATURATION OF HUMAN GLOMERULI AND PROXIMAL CONVOLUTIONS FROM TERM TO ADULTHOOD: STUDIES BY MICRODISSECTION

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12 December 2020

Clinical pharmacokinetics in newborns and infants. Age-related differences and therapeutic implications

1 reference

12 December 2020

Quantitative changes in the canine glomerular vasculature during development: physiologic implications

1 reference

12 December 2020

Immunochemical evidence for the occurrence of Mu class glutathione S-transferase in human fetal livers

1 reference

12 December 2020

SULFOBROMOPHTHALEIN SODIUM (BSP) CONJUGATION AND EXCRETION IN NEONATAL GUINEA PIGS.

1 reference

12 December 2020

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples

1 reference

12 December 2020

Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity.

1 reference

12 December 2020

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence

1 reference

12 December 2020

1 reference

12 December 2020

Significance of cytochrome P-450 (P-450 HFLa) of human fetal livers in the steroid and drug oxidations

1 reference

12 December 2020

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)

1 reference

12 December 2020

Perinatal development of indocyanine green biliary excretion in guinea pigs.

1 reference

12 December 2020

The ultrastructural development of the glomerular filtration barrier in the rat kidney: a morphometric analysis

1 reference

12 December 2020

Multidrug resistance gene (P-glycoprotein) expression in the human fetus

1 reference

12 December 2020

Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions

1 reference

12 December 2020

Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate

1 reference

12 December 2020

Purification and Characterization of Acidic Form of Glutathione S-Transferase in Human Fetal Livers: High Similarity to Placental Form1

1 reference

12 December 2020

Metabolism and Pharmacokinetics of Theophylline in Human Neonates, Children, and Adults

1 reference

12 December 2020

Caffeine and theophylline metabolism in newborn and adult human hepatocytes; comparison with adult rat hepatocytes

1 reference

12 December 2020

Maternal and neonatal urinary excretion of sulfate and glucuronide ritodrine conjugates

1 reference

12 December 2020

Development of glomerular filtration and tubular sodium reabsorption in the human fetus and newborn

1 reference

12 December 2020

Isoniazid acetylation metabolic ratio during maturation in children

1 reference

12 December 2020

Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias

1 reference

12 December 2020

Uptake of taurocholate by hepatocytes isolated from developing rats.

1 reference

12 December 2020

Theophylline A “State of the Art” Review

1 reference

12 December 2020

Steady state serum concentrations and renal clearance of digoxin in neonates, infants and children

1 reference

12 December 2020

Acetyltransferase in humans: development and tissue distribution

1 reference

12 December 2020

Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells

1 reference

12 December 2020

Cytochrome P450 3A: ontogeny and drug disposition

1 reference

12 December 2020

Glomerular filtration rate in the first three weeks of life

1 reference

12 December 2020

Milk antigen absorption in the preterm and term neonate

1 reference

12 December 2020

Toxicokinetics in infants and children in relation to the ADI and TDI.

1 reference

12 December 2020

Galactose clearance measurements and liver blood flow

1 reference

12 December 2020

Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility.

1 reference

12 December 2020

The pharmacokinetics and metabolism of the anilide local anaesthetics in neonates. I. Lignocaine.

1 reference

12 December 2020

Postnatal development of organic cation transport and mdr gene expression in mouse kidney

1 reference

12 December 2020

Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct

1 reference

12 December 2020

Cytomorphometry of developing rat liver and its application to enzymic differentiation

1 reference

12 December 2020

Characterization of human fetal hepatic cytochrome P-450-associated 7-ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase activities by monoclonal antibodies

1 reference

12 December 2020

Postnatal development of renal function in pre-term and full-term infants

1 reference

12 December 2020

Renal clearances of sodium penicillin G, procaine penicillin G, and inulin in infants and children

1 reference

12 December 2020

In situ hybridization demonstrates the stability of mRNA in post-mortem rat tissues

1 reference

12 December 2020

THE ESTIMATION OF HEPATIC BLOOD FLOW IN MAN.

1 reference

12 December 2020

Caffeine overdose in a premature infant: clinical course and pharmacokinetics

1 reference

12 December 2020

The physiologic and clinical significance of immaturity of kidney function in young infants

1 reference

12 December 2020

Human embryonic cytochrome P450S: phenoxazone ethers as probes for expression of functional isoforms during organogenesis

1 reference

12 December 2020

1 reference

12 December 2020

Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation

1 reference

12 December 2020

1998 International Meeting on the Arylamine N-Acetyltransferases: synopsis of the workshop on nomenclature, biochemistry, molecular biology, interspecies comparisons, and role in human disease risk.

1 reference

12 December 2020

Drug metabolism in the newborn.

1 reference

12 December 2020

Liver volume as a determinant of drug clearance in children and adolescents

1 reference

12 December 2020

Vancomycin pharmacokinetics in neonates and infants: a retrospective evaluation.

1 reference

12 December 2020

Theophylline misadventures: Part II.

1 reference

12 December 2020

Cytochrome P-450 expression in sudden infant death syndrome

1 reference

12 December 2020

RENAL EXTRACTION OF PARA-AMINOHIPPURATE IN INFANTS AND CHILDREN.

1 reference

12 December 2020

Inulin clearance in the newborn infant: relationship to gestational and postnatal age

1 reference

12 December 2020

Non invasive in vivo study of the maturation of CYP IIIA in neonates and infants

1 reference

12 December 2020

Transfer of PCBs via lactation simultaneously induces the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf in neonates

1 reference

12 December 2020

Clinical pharmacokinetics in infants and children

1 reference

12 December 2020

Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7

1 reference

12 December 2020

Theophylline misadventures: Part I.

1 reference

12 December 2020

P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate

1 reference

12 December 2020

Estimation of hepatic blood flow with indocyanine green

1 reference

12 December 2020

Interrelationship between glomerular filtration rate and renal transport of sodium and chloride during fetal life

1 reference

12 December 2020

Morphine pharmacokinetics in early infancy.

1 reference

12 December 2020

Immaturity of the newborn rat's hepatic excretory function for ouabain

1 reference

12 December 2020

Pediatric Clinical Pharmacology and the "Therapeutic Orphan"

1 reference

12 December 2020

10.2165/00003088-200241120-00003

Identifiers

DOI

1 reference

Dimensions Publication ID

4 August 2017

1004419281

0 references

1 reference