(Q33700129)

28 July 2017

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title

Glucuronidation in humans. Pharmacogenetic and developmental aspects (English)

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28 July 2017

2

Kearns GL

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28 July 2017

de Wildt SN

1

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28 July 2017

Leeder JS

series ordinal

3

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28 July 2017

van den Anker JN

series ordinal

4

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28 July 2017

language of work or name

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1 June 1999

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Clinical Pharmacokinetics

28 July 2017

published in

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28 July 2017

volume

36

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28 July 2017

issue

6

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28 July 2017

page(s)

439-452

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New developments in glucuronidation research: report of a workshop on "glucuronidation, its role in health and disease"

28 July 2017

cites work

1 reference

12 December 2020

Ethnic differences in response to morphine

1 reference

12 December 2020

Interindividual and interethnic differences in the demethylation and glucuronidation of codeine

1 reference

12 December 2020

The pharmacokinetics of propofol in children using three different data analysis approaches.

1 reference

12 December 2020

Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver

1 reference

12 December 2020

The Maturation of Morphine Clearance and Metabolism

1 reference

12 December 2020

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man

1 reference

12 December 2020

Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.

1 reference

12 December 2020

Interindividual variability in the glucuronidation of (S) oxazepam contrasted with that of (R) oxazepam.

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12 December 2020

Glucuronidation and its Role in Regulation of Biological Activity of Drugs

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12 December 2020

The prenatal and postnatal development of UDP-glucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver

1 reference

12 December 2020

A pharmacokinetically based propofol dosing strategy for sedation of the critically ill, mechanically ventilated pediatric patient

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12 December 2020

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini

1 reference

12 December 2020

Structure and function of uridine diphosphate glucuronosyltransferases

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12 December 2020

Development of human liver UDP-glucuronosyltransferases.

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12 December 2020

Differential localisation of UDP-glucuronosyltransferase in kidney during human embryonic and fetal development

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12 December 2020

Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation

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12 December 2020

Dextromethorphan O-demethylation and dextrorphan glucuronidation in a French population

1 reference

12 December 2020

Glucuronidation of propofol in microsomal fractions from various tissues and species including humans: effect of different drugs

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12 December 2020

The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes.

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12 December 2020

Postoperative morphine infusion in newborn infants: assessment of disposition characteristics and safety.

1 reference

12 December 2020

Chromosomal Localization, Structure, and Regulation of theUGT2B17Gene, Encoding a C19 Steroid Metabolizing Enzyme

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12 December 2020

Morphine glucuronidation in human fetal and adult liver

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12 December 2020

Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol.

1 reference

12 December 2020

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1 reference

12 December 2020

UGT1*1 genotyping in a Canadian Inuit population

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12 December 2020

Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

1 reference

12 December 2020

Propofol metabolism in man during the anhepatic and reperfusion phases of liver transplantation

1 reference

12 December 2020

A size standard for pharmacokinetics.

1 reference

12 December 2020

Chloramphenicol in the newborn infant. A physiologic explanation of its toxicity when given in excessive doses

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12 December 2020

Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports

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12 December 2020

The ontogeny of key endoplasmic reticulum proteins in human embryonic and fetal red blood cells.

1 reference

12 December 2020

Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2

1 reference

12 December 2020

Gilbert's syndrome is caused by a heterozygous missense mutation in the gene for bilirubin UDP-glucuronosyltransferase

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12 December 2020

A study of conjugation and drug elimination in the human neonate

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12 December 2020

Development of the glucuronyltransferase and sulphotransferase towards 2-naphthol in human fetus.

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12 December 2020

Gilbert's disease: a risk factor for paracetamol overdosage?

1 reference

12 December 2020

Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion

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12 December 2020

Human UGT2B7 catalyzes morphine glucuronidation

1 reference

12 December 2020

Normal pathways for glucuronidation, sulphation and oxidation of paracetamol in Gilbert's syndrome

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12 December 2020

The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268)

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12 December 2020

The UGT1A1*28 allele is relatively rare in a Japanese population

1 reference

12 December 2020

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

1 reference

12 December 2020

Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3

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12 December 2020

Kinetics of salicylate elimination by newborn infants of mothers who ingested aspirin before delivery

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12 December 2020

Placental passage of oxazepam and its metabolism in mother and newborn

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12 December 2020

Lorazepam toxicity in a premature infant

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12 December 2020

Altered coding for a strictly conserved di-glycine in the major bilirubin UDP-glucuronosyltransferase of a Crigler-Najjar type I patient

1 reference

12 December 2020

The enantioselective glucuronidation of morphine in rats and humans. Evidence for the involvement of more than one UDP-glucuronosyltransferase isoenzyme

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12 December 2020

Fatal cardiovascular collapse of infants receiving large amounts of chloramphenicol

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12 December 2020

Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients.

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12 December 2020

Glucuronide formation in patients with constitutional hepatic dysfunction (Gilbert's disease)

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12 December 2020

Sulphation and glucuronidation of ritodrine in human foetal and adult tissues

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12 December 2020

Chronic unconjugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults

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12 December 2020

The Human UDP Glucuronosyltransferase, UGT1A10, Glucuronidates Mycophenolic Acid

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12 December 2020

Phase I evaluation of zidovudine administered to infants exposed at birth to the human immunodeficiency virus

1 reference

12 December 2020

Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates

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12 December 2020

Morphine metabolism in children

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12 December 2020

Gilbert syndrome accelerates development of neonatal jaundice

1 reference

12 December 2020

Acetaminophen: Potentially Toxic Metabolite Formed by Human Fetal and Adult Liver Microsomes and Isolated Fetal Liver Cells

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12 December 2020

Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4.

1 reference

12 December 2020

Gilbert syndrome caused by a homozygous missense mutation (Tyr486Asp) of bilirubin UDP-glucuronosyltransferase gene

1 reference

12 December 2020

Development of multiple activities of UDP-glucuronyltransferase in human liver

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12 December 2020

Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications

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12 December 2020

In vitro glucuronidation of 3'-azido-3'-deoxythymidine by human liver. Role of UDP-glucuronosyltransferase 2 form

1 reference

12 December 2020

Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives

1 reference

12 December 2020

Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13

1 reference

12 December 2020

Pharmacokinetics of propofol after a single dose in children aged 1-3 years with minor burns. Comparison of three data analysis approaches

1 reference

12 December 2020

Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family

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12 December 2020

Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms

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12 December 2020

Preclinical prediction of factors influencing the elimination of 5,6-dimethylxanthenone-4-acetic acid, a new anticancer drug

1 reference

12 December 2020

Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids

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12 December 2020

Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture

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12 December 2020

Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors

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12 December 2020

Conjugation-deconjugation reactions in drug metabolism and toxicity.

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12 December 2020

Clinical pharmacokinetics in newborns and infants. Age-related differences and therapeutic implications

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12 December 2020

Isolation and characterization of UGT2B15(Y85): a UDP glucuronosyltransferase encoded by a polymorphic gene

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12 December 2020

Characterisation of a human bilirubin UDP-glucuronosyltransferase stably expressed in hamster lung fibroblast cell cultures

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12 December 2020

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence

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12 December 2020

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12 December 2020

Tissue-specific 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of human UDP-glucuronosyltransferase UGT1A6.

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12 December 2020

UDP-glucuronosyltransferases

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12 December 2020

Maternal and neonatal urinary excretion of sulfate and glucuronide ritodrine conjugates

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12 December 2020

Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias

1 reference

12 December 2020

Naloxone pharmacokinetics in the newborn

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12 December 2020

Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P450-mediated acute cell injury in cultured rat hepatocytes

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12 December 2020

Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases

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12 December 2020

Lack of a genetic polymorphism in the glucuronidation of fenofibric acid

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12 December 2020

Fetal acquisition and neonatal elimination of a large amount of salicylate. Study of a neonate whose mother regularly took therapeutic doses of aspirin during pregnancy

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12 December 2020

Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells

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12 December 2020

Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase

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12 December 2020

Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro

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12 December 2020

Urinary glucuronide excretion of fenofibric and clofibric acid glucuronides in man. Is it polymorphic?

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12 December 2020

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12 December 2020

Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation

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12 December 2020

Evaluation of pharmacokinetics, safety, tolerance, and activity of combination of zalcitabine and zidovudine in stable, zidovudine-treated pediatric patients with human immunodeficiency virus infection. AIDS Clinical Trials Group Protocol 190 Team

1 reference

12 December 2020

Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: A dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia

1 reference

12 December 2020

Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein

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12 December 2020

Genotype or phenotype: the definition of a pharmacogenetic polymorphism

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12 December 2020

Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry

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12 December 2020

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

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12 December 2020

Drug glucuronidation in humans

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12 December 2020

The genetic basis of Gilbert's syndrome

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12 December 2020

10.2165/00003088-199936060-00005

Identifiers

DOI

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Dimensions Publication ID

28 July 2017

1005530197

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