(Q34869589)

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Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378396%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1 (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378396%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378396%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Des R. Richardson

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378396%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Yu Yu

1

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Europe PubMed Central

PubMed publication ID

5 August 2017

Des R Richardson

2

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5 August 2017

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5 March 2011

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24 January 2020

Journal of Biological Chemistry

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378396%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

286

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24 January 2020

17

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378396%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

15413-15427

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378396%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake.

1 reference

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Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate

1 reference

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Modulation of intracellular iron levels by oxidative stress implicates a novel role for iron in signal transduction

1 reference

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8 July 2018

The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells

1 reference

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LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins

1 reference

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Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

1 reference

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Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

1 reference

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Tumor necrosis factor-alpha-induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool

1 reference

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Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.

1 reference

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8 July 2018

MAP kinase signalling pathways in cancer

1 reference

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8 July 2018

Role of mitogen-activated protein kinase kinase kinases in signal integration

1 reference

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8 July 2018

Differential regulation and properties of MAPKs

1 reference

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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.

1 reference

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8 July 2018

Identification of distinct changes in gene expression after modulation of melanoma tumor antigen p97 (melanotransferrin) in multiple models in vitro and in vivo

1 reference

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8 July 2018

Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion

1 reference

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8 July 2018

Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression

1 reference

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8 July 2018

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

1 reference

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8 July 2018

Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates

1 reference

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8 July 2018

Iron chelator induces THP-1 cell differentiation potentially by modulating intracellular glutathione levels

1 reference

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8 July 2018

The evolution of iron chelators for the treatment of iron overload disease and cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

Molecular mechanisms of iron uptake by cells and the use of iron chelators for the treatment of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

The functional interactions between the p53 and MAPK signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

Downregulation of p38 kinase pathway by cAMP response element-binding protein protects HL-60 cells from iron chelator-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

The role of iron chelation in cancer therapy

1 reference

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8 July 2018

Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death

1 reference

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8 July 2018

The role of iron in cell cycle progression and the proliferation of neoplastic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1

1 reference

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8 July 2018

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

Iron chelators inhibit the growth and induce the apoptosis of Kaposi's sarcoma cells and of their putative endothelial precursors.

1 reference

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8 July 2018

Control of the eukaryotic cell cycle by MAP kinase signaling pathways.

1 reference

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8 July 2018

A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

1 reference

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8 July 2018

Stress signals utilize multiple pathways to stabilize p53

1 reference

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8 July 2018

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

1 reference

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8 July 2018

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

1 reference

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8 July 2018

Signal transduction through MAP kinase cascades

1 reference

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8 July 2018

Iron deprivation inhibits cyclin-dependent kinase activity and decreases cyclin D/CDK4 protein levels in asynchronous MDA-MB-453 human breast cancer cells

1 reference

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8 July 2018

Up-regulation of vascular endothelial growth factor production by iron chelators

1 reference

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8 July 2018

Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase

1 reference

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8 July 2018

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

1 reference

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8 July 2018

Neuroblastoma sensitivity to growth inhibition by deferrioxamine: evidence for a block in G1 phase of the cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun

1 reference

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8 July 2018

Iron chelators induce apoptosis in proliferating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

Transcription factor ATF2 regulation by the JNK signal transduction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

Effects of a single course of deferoxamine in neuroblastoma patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

The uptake of iron and transferrin by the human malignant melanoma cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083220

8 July 2018

Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.225946

21 January 2018

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.225946

21 January 2018

Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.225946

21 January 2018

Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.225946

21 January 2018

Cell stress-induced phosphorylation of ATF2 and c-Jun transcription factors in rat ventricular myocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.225946

21 January 2018

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: an EPR study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.225946

21 January 2018

Desferrioxamine (DFX) induces apoptosis through the p38-caspase8-Bid-Bax pathway in PHA-stimulated human lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.225946

21 January 2018

Ferritin production and desferrioxamine cytotoxicity in human neuroblastoma cell lines.

1 reference

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26 October 2018

Antineuroblastoma activity of desferoxamine in human cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21378396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21378396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron deprivation-induced apoptosis in HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21378396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of iron-depletion on cell cycle progression in normal human T lymphocytes: selective inhibition of the appearance of the cyclin A-associated component of the p33cdk2 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21378396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21378396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21378396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: the effect of the ligands on molecular targets involved in proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21378396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo effects of deferoxamine in neonatal acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21378396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.225946

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378396%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378396%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378396%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

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