(Q39889950)

15 September 2017

title

The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells (English)

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15 September 2017

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6

Yves Pommier

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15 September 2017

V Ashutosh Rao

1

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15 September 2017

Sarah R Klein

2

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15 September 2017

Keli K Agama

3

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15 September 2017

Eriko Toyoda

4

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15 September 2017

Noritaka Adachi

5

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15 September 2017

Emily B Shacter

7

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15 September 2017

language of work or name

English

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publication date

27 January 2009

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15 September 2017

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15 September 2017

volume

69

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15 September 2017

issue

3

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15 September 2017

page(s)

948-957

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Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development

15 September 2017

cites work

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12 December 2020

Topoisomerase I inhibitors: camptothecins and beyond

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12 December 2020

Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

1 reference

12 December 2020

Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion

1 reference

12 December 2020

Cellular roles of dna topoisomerases: a molecular perspective

1 reference

12 December 2020

DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.

1 reference

12 December 2020

A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane).

1 reference

12 December 2020

Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: effect on the R2 subunit of ribonucleotide reductase.

1 reference

12 December 2020

Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation

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12 December 2020

Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression

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12 December 2020

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12 December 2020

The DNA damage response: ten years after

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12 December 2020

A simple technique for quantitation of low levels of DNA damage in individual cells

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12 December 2020

Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment.

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12 December 2020

Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage

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12 December 2020

Regulation of iron acquisition and storage: consequences for iron-linked disorders

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12 December 2020

Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells

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12 December 2020

Combining etoposide and dexrazoxane synergizes with radiotherapy and improves survival in mice with central nervous system tumors

1 reference

12 December 2020

Neuroblastoma sensitivity to growth inhibition by deferrioxamine: evidence for a block in G1 phase of the cell cycle

1 reference

12 December 2020

Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management

1 reference

12 December 2020

Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin

1 reference

12 December 2020

Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals.

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12 December 2020

The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.

1 reference

12 December 2020

DNA topoisomerases: structure, function, and mechanism

1 reference

12 December 2020

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

1 reference

12 December 2020

Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves fenton-derived free radical generation

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12 December 2020

NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.

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12 December 2020

Iron chelators in cancer chemotherapy

1 reference

12 December 2020

Chelators at the cancer coalface: desferrioxamine to Triapine and beyond.

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12 December 2020

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

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12 December 2020

A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells

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12 December 2020

Cell cycle arrest at the initiation step of human chromosomal DNA replication causes DNA damage

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12 December 2020

Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIalpha

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12 December 2020

Failure of iron chelators to reduce tumor growth in human neuroblastoma xenografts

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12 December 2020

Structure/function overview of proteins involved in iron storage and transport

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12 December 2020

Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks

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12 December 2020

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

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12 December 2020

Tuning cell cycle regulation with an iron key.

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12 December 2020

The role of iron regulatory proteins in mammalian iron homeostasis and disease

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12 December 2020

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines

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12 December 2020

Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay

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12 December 2020

Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?

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12 December 2020

Coordination chemistry and biology of chelators for the treatment of iron overload disorders

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12 December 2020

Preclinical models of cardiac protection and testing for effects of dexrazoxane on doxorubicin antitumor effects.

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12 December 2020

Transferrin and transferrin receptors in carcinoma of the breast

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12 December 2020

Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane

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12 December 2020

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

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12 December 2020

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

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12 December 2020

Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: Possible regulation mechanism

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12 December 2020

Characteristics of gamma-H2AX foci at DNA double-strand breaks sites

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12 December 2020

10.1158/0008-5472.CAN-08-1437

Identifiers

DOI

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15 September 2017

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