(Q40244137)

English

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

scientific article published on 10 August 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

colorectal carcinoma

1 reference

based on heuristic

inferred from title

ataxia telangiectasia

1 reference

based on heuristic

inferred from title

8

object named as

Yves Pommier

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

author name string

Haruyuki Takemura

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

V Ashutosh Rao

2

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Olivier Sordet

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Takahisa Furuta

4

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Ze-Hong Miao

5

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Linghua Meng

6

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Hongliang Zhang

7

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

language of work or name

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publication date

10 August 2006

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Europe PubMed Central

PubMed publication ID

18 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

18 September 2017

281

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

41

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

30814-30823

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

The DNA damage response: putting checkpoints in perspective

1 reference

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Initiating cellular stress responses

1 reference

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DNA damage-induced activation of ATM and ATM-dependent signaling pathways

1 reference

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Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

1 reference

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21 January 2018

Repair of and checkpoint response to topoisomerase I-mediated DNA damage

1 reference

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DNA topoisomerases: structure, function, and mechanism

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Cellular roles of dna topoisomerases: a molecular perspective

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21 January 2018

Topoisomerase I-mediated DNA damage

1 reference

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

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The camptothecins.

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Topotecan: weighing in when there are many options

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CHK2 kinase--a busy messenger.

1 reference

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The Chk2 protein kinase

1 reference

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Targeting chk2 kinase: molecular interaction maps and therapeutic rationale

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

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ATM and related protein kinases: safeguarding genome integrity

1 reference

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The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

1 reference

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Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

1 reference

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21 January 2018

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

1 reference

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21 January 2018

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

1 reference

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21 January 2018

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

1 reference

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21 January 2018

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

1 reference

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21 January 2018

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

1 reference

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21 January 2018

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

1 reference

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21 January 2018

Chk1 and Chk2 kinases in checkpoint control and cancer

1 reference

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant

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Right place, right time, and only once: replication initiation in metazoans

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Human MRE11 is inactivated in mismatch repair-deficient cancers

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RecQ helicases: caretakers of the genome

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

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The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

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21 January 2018

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

1 reference

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A gene expression database for the molecular pharmacology of cancer

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Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

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Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

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Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

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Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

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Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis

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The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons

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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

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Human colon cancer cells surviving high doses of cisplatin or oxaliplatin in vitro are not defective in DNA mismatch repair proteins

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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Identifiers

10.1074/JBC.M603747200

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

ResearchGate publication ID

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