(Q34887778)

5 August 2017

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title

Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells (English)

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5 August 2017

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1

Miriam Merad

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5 August 2017

2

Florent Ginhoux

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5 August 2017

3

Matthew Collin

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5 August 2017

1 December 2008

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Nature Reviews Immunology

5 August 2017

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5 August 2017

8

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5 August 2017

12

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5 August 2017

935-947

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Dendritic cells and the control of immunity

5 August 2017

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Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules

31 March 2020

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Diversity of receptors binding HIV on dendritic cell subsets

31 March 2020

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Langerin is a natural barrier to HIV-1 transmission by Langerhans cells

31 March 2020

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Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state

31 March 2020

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The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells

31 March 2020

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Identification of a novel population of Langerin+ dendritic cells

31 March 2020

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Langerin Expressing Cells Promote Skin Immune Responses under Defined Conditions

31 March 2020

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Langerhans cells arise from monocytes in vivo

31 March 2020

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Ueber die Nerven der menschlichen Haut

31 March 2020

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Origin and Function of Epidermal Langerhans Cells

31 March 2020

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Cutaneous dendritic cells

31 March 2020

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TCR gamma/delta+ dendritic epidermal T cells as constituents of skin-associated lymphoid tissue

31 March 2020

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The fine structure of the Langerhans cell granule

31 March 2020

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Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

31 March 2020

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Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin

31 March 2020

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A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells

31 March 2020

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Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. I. Expression on dendritic cells and other subsets of mouse leukocytes

31 March 2020

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The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

31 March 2020

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Reactivity of Langerhans cells with hybridoma antibody

31 March 2020

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Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

31 March 2020

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TGFbeta inhibits CD1d expression on dendritic cells

31 March 2020

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Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin accumulates

31 March 2020

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Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues

31 March 2020

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Identification and expression of mouse Langerin (CD207) in dendritic cells

31 March 2020

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Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function

31 March 2020

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A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene

31 March 2020

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Functional anatomy of lymph nodes. II. Peripheral lymph-borne mononuclear cells

31 March 2020

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A study of cells present in peripheral lymph of pigs with special reference to a type of cell resembling the langerhans cell

31 March 2020

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Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells.

31 March 2020

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Migratory Langerhans cells in mouse lymph nodes in steady state and inflammation

31 March 2020

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Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies

31 March 2020

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Migration of dendritic cell subsets and their precursors.

31 March 2020

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Migration and maturation of Langerhans cells in skin transplants and explants

31 March 2020

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Developmental regulation of MHC class II transport in mouse dendritic cells.

31 March 2020

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Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes

31 March 2020

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CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions

31 March 2020

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Multistep navigation of Langerhans/dendritic cells in and out of the skin

31 March 2020

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High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodes

31 March 2020

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Epidermal Langerhans cells are derived from cells originating in bone marrow

31 March 2020

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Mouse epidermal Ia molecules have a bone marrow origin

31 March 2020

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Langerhans cells renew in the skin throughout life under steady-state conditions

31 March 2020

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Vaginal epithelial dendritic cells renew from bone marrow precursors

31 March 2020

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Origin of dendritic cells in peripheral lymphoid organs of mice.

31 March 2020

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Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease

31 March 2020

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Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover.

31 March 2020

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Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.

31 March 2020

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Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity

31 March 2020

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In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens

31 March 2020

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Epidermal Langerhans cells--a cycling cell population

31 March 2020

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Further evidence for the self-reproducing capacity of Langerhans cells in human skin

31 March 2020

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Langerhans cells: uptake of tritiated thymidine

31 March 2020

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Biology of Langerhans cells: selective migration of Langerhans cells into allogeneic and xenogeneic grafts on nude mice

31 March 2020

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Turnover of epidermal Langerhans' cells

31 March 2020

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The fate of human Langerhans cells in hematopoietic stem cell transplantation

31 March 2020

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DC homeostasis in hematopoietic stem cell transplantation

31 March 2020

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Epidermal Langerhans cells undergo mitosis during the early recovery phase after ultraviolet-B irradiation

31 March 2020

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Hair follicles serve as local reservoirs of skin mast cell precursors

31 March 2020

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Epidermal stem cells of the skin

31 March 2020

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The human hair follicle: a reservoir of CD40+ B7-deficient Langerhans cells that repopulate epidermis after UVB exposure.

31 March 2020

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Langerhans cells are required for efficient presentation of topically applied hapten to T cells

31 March 2020

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Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells

31 March 2020

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Transforming growth factor beta1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells

31 March 2020

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Transcriptional profiling identifies Id2 function in dendritic cell development

31 March 2020

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Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation

31 March 2020

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Discovery of a cytokine and its receptor by functional screening of the extracellular proteome

31 March 2020

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Biology and action of colony--stimulating factor-1

31 March 2020

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Flt3 in regulation of type I interferon-producing cell and dendritic cell development

31 March 2020

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Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men.

31 March 2020

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CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 c

31 March 2020

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CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue.

31 March 2020

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Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces

31 March 2020

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Dermal-resident CD14+ cells differentiate into Langerhans cells

31 March 2020

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Cutaneous CXCL14 targets blood precursors to epidermal niches for Langerhans cell differentiation

31 March 2020

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Dendritic cells in a mature age.

31 March 2020

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Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation

31 March 2020

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Immunobiology of dendritic cells

31 March 2020

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Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207.

31 March 2020

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Accumulation of immature Langerhans cells in human lymph nodes draining chronically inflamed skin

31 March 2020

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Mouse lymphoid tissue contains distinct subsets of langerin/CD207 dendritic cells, only one of which represents epidermal-derived Langerhans cells

31 March 2020

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Production of monoclonal antibodies that recognize the extracellular domain of mouse langerin/CD207.

31 March 2020

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Expression of langerin/CD207 reveals dendritic cell heterogeneity between inbred mouse strains

31 March 2020

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Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers

31 March 2020

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Recruitment of dendritic cells in oral lichen planus

31 March 2020

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A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins

31 March 2020

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Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing

31 March 2020

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Langerin (CD207) staining in normal pediatric tissues, reactive lymph nodes, and childhood histiocytic disorders

31 March 2020

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B cells and tertiary lymphoid organs in renal inflammation

31 March 2020

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Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans.

31 March 2020

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The development, maturation, and turnover rate of mouse spleen dendritic cell populations.

31 March 2020

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A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

31 March 2020

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Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues

31 March 2020

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Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance

31 March 2020

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Differential antigen processing by dendritic cell subsets in vivo

31 March 2020

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Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro

31 March 2020

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Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells

31 March 2020

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Skin-derived dendritic cells induce potent CD8(+) T cell immunity in recombinant lentivector-mediated genetic immunization

31 March 2020

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Herpes simplex virus type 2 induces rapid cell death and functional impairment of murine dendritic cells in vitro

31 March 2020

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Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells

31 March 2020

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Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania

31 March 2020

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Metacyclogenesis in Leishmania promastigotes

31 March 2020

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CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major.

31 March 2020

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Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells

31 March 2020

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Dendritic cell subsets in health and disease.

31 March 2020

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Epidermal Langerhans Cells Are Dispensable for Humoral and Cell-Mediated Immunity Elicited by Gene Gun Immunization

31 March 2020

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Tumor immunotherapy by epicutaneous immunization requires langerhans cells.

31 March 2020

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Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity

31 March 2020

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Tolerogenic dendritic cells

31 March 2020

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Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells

31 March 2020

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Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells

31 March 2020

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Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity

31 March 2020

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Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells

31 March 2020

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Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

31 March 2020

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CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells

31 March 2020

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The Langerhans cell histiocytosis X files revealed

31 March 2020

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Differentiation of Langerhans cells in Langerhans cell histiocytosis

31 March 2020

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In situ expression of activation markers by Langerhans' cells containing GM-CSF

31 March 2020

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An hypothesis Langerhans cell histiocytosis: the failure of the immune system to switch from an innate to an adaptive mode

31 March 2020

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Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis

31 March 2020

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Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease.

31 March 2020

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Expansion of regulatory T cells in patients with Langerhans cell histiocytosis

31 March 2020

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Expression of cell cycle-related gene products in Langerhans cell histiocytosis.

31 March 2020

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Bcl-2 Expression in Langerhans' Cell Histiocytosis

31 March 2020

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CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells

31 March 2020

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TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor

31 March 2020

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Biology of Langerhans cells and Langerhans cell histiocytosis

31 March 2020

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In vivo transformation of mouse conventional CD8alpha+ dendritic cells leads to progressive multisystem histiocytosis.

31 March 2020

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Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases.

31 March 2020

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C-type lectin receptors on dendritic cells and Langerhans cells

31 March 2020

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Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo

31 March 2020

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The interaction of HIV with dendritic cells: outcomes and pathways

31 March 2020

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Setting the stage: host invasion by HIV.

31 March 2020

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Activated CD34-derived Langerhans cells mediate transinfection with human immunodeficiency virus

31 March 2020

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Identification and characterization of an alternatively spliced isoform of mouse Langerin/CD207.

31 March 2020

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Polymorphisms in human langerin affect stability and sugar binding activity

31 March 2020

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T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.

31 March 2020

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Absence of donor-type major histocompatibility complex class I antigen-bearing microglia in the rat central nervous system of radiation bone marrow chimeras

31 March 2020

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Origins and functions of B-1 cells with notes on the role of CD5

31 March 2020

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Dendritic cell genealogy: a new stem or just another branch?

31 March 2020

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Heterogeneity of dendritic cells in human superficial lymph node: in vitro maturation of immature dendritic cells into mature or activated interdigitating reticulum cells.

31 March 2020

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ICSBP is critically involved in the normal development and trafficking of Langerhans cells and dermal dendritic cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2455

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5 August 2017

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PubMed ID

19029989