(Q34926526)

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Pro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia.

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20 January 2020

Pro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia (English)

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20 January 2020

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20 January 2020

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20 January 2020

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Michal Arad

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20 January 2020

Amaya De Levie

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20 January 2020

Mark D Black

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20 January 2020

Ina Weiner

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20 January 2020

Neuropsychopharmacology

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20 January 2020

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20 January 2020

https://scigraph.springernature.com/pub.10.1038/npp.2008.232

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Schizophrenia, sensory gating, and nicotinic receptors.

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The disorder of consciousness in schizophrenia.

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Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21.

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The many faces of nitric oxide in schizophrenia. A review

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SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (1) binding and functional profile

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On the effect of neonatal nitric oxide synthase inhibition in rats: a potential neurodevelopmental model of schizophrenia

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Neonatal nitric oxide synthase inhibition: social interaction deficits in adulthood and reversal by antipsychotic drugs

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Recent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophrenia

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Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

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Animal models for the negative symptoms of schizophrenia

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Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

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Cholinergic targets for cognitive enhancement in schizophrenia: focus on cholinesterase inhibitors and muscarinic agonists

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Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine.

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Abnormally persistent latent inhibition induced by MK801 is reversed by risperidone and by positive modulators of NMDA receptor function: differential efficacy depending on the stage of the task at which they are administered

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21 January 2018

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

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21 January 2018

Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior

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21 January 2018

Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition

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21 January 2018

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia

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21 January 2018

Latent inhibition: the nucleus accumbens connection revisited

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Decreased protein level of nicotinic receptor alpha7 subunit in the frontal cortex from schizophrenic brain

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21 January 2018

Targeting information-processing deficit in schizophrenia: a novel approach to psychotherapeutic drug discovery

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21 January 2018

The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetize

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21 January 2018

Alpha-7 nicotinic acetylcholine receptor agonists selectively activate limbic regions of the rat forebrain: an effect similar to antipsychotics

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21 January 2018

Treatment of cognitive impairment in early psychosis: a comparison of risperidone and haloperidol in a large long-term trial

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21 January 2018

Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711.

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21 January 2018

The role of acetylcholine in learning and memory

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21 January 2018

The primacy of cognition in schizophrenia

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21 January 2018

D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia

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21 January 2018

Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.

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21 January 2018

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

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21 January 2018

Recent advances in the phencyclidine model of schizophrenia

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21 January 2018

Impaired inhibition of conditioned responses produced by subchronic administration of phencyclidine to rats

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21 January 2018

Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia

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21 January 2018

Glutamate-mediated plasticity in corticostriatal networks: role in adaptive motor learning.

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21 January 2018

The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21).

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21 January 2018

The changing roles and targets for animal models of schizophrenia

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NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

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21 January 2018

Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

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21 January 2018

Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade

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21 January 2018

Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia

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21 January 2018

To model a psychiatric disorder in animals: schizophrenia as a reality test

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21 January 2018

Construct Validity of the Animal Latent Inhibition Model of Selective Attention Deficits in Schizophrenia

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21 January 2018

The construct of attention in schizophrenia

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21 January 2018

Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells

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21 January 2018

Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia

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21 January 2018

Anabasine, a selective nicotinic acetylcholine receptor agonist, antagonizes MK-801-elicited mouse popping behavior, an animal model of schizophrenia

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21 January 2018

The differential effects of chlorpromazine and haloperidol on latent inhibition in healthy volunteers

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21 January 2018

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Cognitive inflexibility and pre-frontal dysfunction in schizophrenia and mania

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21 January 2018

Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia

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21 January 2018

Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to men.

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21 January 2018

The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics?

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21 January 2018

SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.

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21 January 2018

Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder?

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21 January 2018

Savings tests: separating differences in rate of learning from differences in initial levels.

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21 January 2018

Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats

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21 January 2018

Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapine

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21 January 2018

Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis

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21 January 2018

Cortical cholinergic inputs mediating arousal, attentional processing and dreaming: differential afferent regulation of the basal forebrain by telencephalic and brainstem afferents

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21 January 2018

Cortical cholinergic transmission and cortical information processing in schizophrenia

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21 January 2018

Nicotine and food induced dopamine release in the nucleus accumbens of the rat: putative role of alpha7 nicotinic receptors in the ventral tegmental area.

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21 January 2018

Effects of alpha 4/beta 2- and alpha 7-nicotine acetylcholine receptor agonists on prepulse inhibition of the acoustic startle response in rats and mice

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21 January 2018

The latent inhibition model dissociates between clozapine, haloperidol, and ritanserin.

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21 January 2018

Linking animal models of psychosis to computational models of dopamine function.

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21 January 2018

Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: possible involvement of central nicotinic alpha7 receptors

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21 January 2018

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

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21 January 2018

An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo

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21 January 2018

The NMDA-receptor antagonist MK-801 selectively disrupts reversal learning in rats

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21 January 2018

AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors

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21 January 2018

The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

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21 January 2018

The switching model of latent inhibition: an update of neural substrates

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21 January 2018

Abolition of the expression but not the acquisition of latent inhibition by chronic amphetamine in rats.

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21 January 2018

Disruption of latent inhibition by acute administration of low doses of amphetamine.

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21 January 2018

Dynamic testing in schizophrenia: does training change the construct validity of a test?

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21 January 2018

Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity rela

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21 January 2018

Nicotine: from molecular mechanisms to behaviour

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21 January 2018

Latent inhibition of conditioned dopamine release in rat nucleus accumbens.

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21 January 2018

Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor

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21 January 2018

Effects of nicotine and amphetamine on latent inhibition in human subjects

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21 January 2018

Context, time, and memory retrieval in the interference paradigms of Pavlovian learning

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7 January 2021

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Effects of typical and atypical neuroleptics on Fos protein expression in the rat forebrain

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7 January 2021

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Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection.

1 reference

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7 January 2021

based on heuristic

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Systemic administration of MK-801 produces an abnormally persistent latent inhibition which is reversed by clozapine but not haloperidol.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.232

7 January 2021

based on heuristic

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The dopamine system and the pathophysiology of schizophrenia: a basic science perspective

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7 January 2021

based on heuristic

inferred from DOI database lookup

High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation

1 reference

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7 January 2021

based on heuristic

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Glutamate receptor-dependent modulation of dopamine efflux in the nucleus accumbens by basolateral, but not central, nucleus of the amygdala in rats.

1 reference

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7 January 2021

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The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking

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7 January 2021

based on heuristic

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Amygdala regulation of nucleus accumbens dopamine output is governed by the prefrontal cortex.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.232

7 January 2021

based on heuristic

inferred from DOI database lookup

AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.232

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.232

7 January 2021

based on heuristic

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Glutamatergic animal models of schizophrenia

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7 January 2021

based on heuristic

inferred from DOI database lookup

The pharmacology of latent inhibition as an animal model of schizophrenia

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https://api.crossref.org/works/10.1038%2FNPP.2008.232

7 January 2021

based on heuristic

inferred from DOI database lookup

Towards a muscarinic hypothesis of schizophrenia.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.232

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical features of latent inhibition in schizophrenia

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area

1 reference

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7 January 2021

based on heuristic

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Dopamine, prediction error and associative learning: a model-based account

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs

1 reference

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7 January 2021

based on heuristic

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Lesions of the dorsomedial nucleus of the thalamus, medial prefrontal cortex and pedunculopontine nucleus: effects on locomotor activity mediated by nucleus accumbens-ventral pallidal circuitry

1 reference

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7 January 2021

based on heuristic

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Both nicotine and mecamylamine block dizocilpine-induced explosive jumping behavior in mice: psychiatric implications

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7 January 2021

based on heuristic

inferred from DOI database lookup

Neural substrates of latent inhibition: the switching model

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.232

7 January 2021

based on heuristic

inferred from DOI database lookup

Haloperidol enhances latent inhibition in visual tasks in healthy people

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.232

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.232

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/NPP.2008.232

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19158670%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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1 reference

Europe PubMed Central

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20 January 2020

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