(Q34926666)

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Acute promyelocytic leukemia: a model for the role of molecular diagnosis and residual disease monitoring in directing treatment approach in acute myeloid leukemia

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

Europe PubMed Central

Acute promyelocytic leukemia: a model for the role of molecular diagnosis and residual disease monitoring in directing treatment approach in acute myeloid leukemia (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

based on heuristic

inferred from title

acute promyelocytic leukemia

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based on heuristic

inferred from title

author name string

Grimwade D

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Lo Coco F

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

publication date

1 October 2002

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

16

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1959-1973

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

https://scigraph.springernature.com/pub.10.1038/sj.leu.2402721

0 references

Treatment of acute promyelocytic leukaemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

All-trans-retinoic acid in acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Low incidence of MDR1 expression in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment of newly diagnosed acute promyelocytic leukemia without cytarabine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial. UK Medical Research Council Adult and Children's Leukaemia Working Par

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

The value of allogeneic bone marrow transplant in patients with acute myeloid leukaemia at differing risk of relapse: results of the UK MRC AML 10 trial

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Experience with gemtuzumab ozogamycin ("mylotarg") and all-trans retinoic acid in untreated acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a 15; 17 translocation in every patient with acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

The theory of APL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Translocations of the RARalpha gene in acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Function of RARalpha during the maturation of neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

PML/RAR-alpha rearrangement in acute promyelocytic leukaemias apparently lacking the t(15;17) translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular analysis of simple variant translocations in acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional regulation in acute promyelocytic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

The pathogenesis of acute promyelocytic leukaemia: evaluation of the role of molecular diagnosis and monitoring in the management of the disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunophenotype of adult and childhood acute promyelocytic leukaemia: correlation with morphology, type of PML gene breakpoint and clinical outcome. A cooperative Italian study on 196 cases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Prognostic significance of minimal residual disease detection and PML/RAR-alpha isoform type: long-term follow-up in acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro all-trans retinoic acid sensitivity of acute promyelocytic leukemia blasts: a novel indicator of poor patient outcome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

The significance of minimal residual disease in patients with t(15;17).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Screening for core binding factor gene rearrangements in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Deregulation of NPM and PLZF in a variant t(5;17) case of acute promyelocytic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

A case of cryptic acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

PML/RAR alpha APL with undifferentiated morphology and stem cell immunophenotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the t(15;17) in AML FAB types other than M3: evaluation of the role of molecular screening for the PML/RARalpha rearrangement in newly diagnosed AML. The Medical Research Council (MRC) Adult Leukaemia Working Party

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Acute myeloblastic leukaemias of FAB types M6 and M4, with cryptic PML/RARalpha fusion gene formation, relapsing as acute promyelocytic leukaemia M3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RARalpha, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia. MRC Adult Leukaemia Working Party. Medical Research Council

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of karyotypic aberrations in acute myeloblastic leukaemia: a prospective comparison between PCR/FISH and standard cytogenetics in 140 patients with de novo AML

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of prognostic factors in newly diagnosed acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy. Japan Adult Leukemia Study Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

CD56 expression in acute promyelocytic leukemia: a possible indicator of poor treatment outcome?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Pretreatment characteristics and clinical outcome of acute promyelocytic leukaemia patients according to the PML-RAR alpha isoforms: a study of the PETHEMA group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Double induction strategy including high dose cytarabine in combination with all-trans retinoic acid: effects in patients with newly diagnosed acute promyelocytic leukemia. German AML Cooperative Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular evaluation of residual disease as a predictor of relapse in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Relapse of acute promyelocytic leukemia follows serial negative RT-PCR assays: a cautionary tale

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantification of PML-RARalpha transcripts in acute promyelocytic leukaemia: explanation for the lack of sensitivity of RT-PCR for the detection of minimal residual disease and induction of the leukaemia-specific mRNA by alpha interferon

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Monitoring minimal residual disease and predicting relapse in APL by quantitating PML-RARalpha transcripts with a sensitive competitive RT-PCR method.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Persistence of RAR alpha-PML fusion mRNA detected by reverse transcriptase polymerase chain reaction in patients in long-term remission of acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

[Monitoring of minimal residual disease with the combined detection of PML/RAR alpha and RAR alpha/PML rearrangements in acute promyelocytic leukemia]

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

RT-PCR method with increased sensitivity shows persistence of PML-RARA fusion transcripts in patients in long-term remission of APL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular monitoring of residual disease using antigen receptor genes in childhood acute lymphoblastic leukaemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Early immunophenotypical evaluation of minimal residual disease in acute myeloid leukemia identifies different patient risk groups and may contribute to postinduction treatment stratification

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Prolonged molecular remission after PML/RAR alpha-positive autologous peripheral blood stem cell transplantation in acute promyelocytic leukemia: is relevant pretransplant minimal residual disease in the graft?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment of relapsing acute promyelocytic leukemia by all-trans retinoic acid therapy followed by timed sequential chemotherapy and stem cell transplantation. APL Study Group. Acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Absence of detectable PML-RAR alpha fusion transcripts in long-term remission patients after BMT for acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Salvage of patients with acute promyelocytic leukaemia with residual disease following ABMT performed in second CR using all-trans retinoic acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Antibody therapy for residual disease in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Prolonged molecular remission in advanced acute promyelocytic leukaemia after treatment with gemtuzumab ozogamicin (Mylotarg CMA-676)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in v

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Pre-clinical validation of a novel, highly sensitive assay to detect PML-RARalpha mRNA using real-time reverse-transcription polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitation of minimal residual disease in acute promyelocytic leukemia patients with t(15;17) translocation using real-time RT-PCR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Pulsed ATRA as single therapy restores long-term remission in PML-RARalpha-positive acute promyelocytic leukemia patients: real time quantification of minimal residual disease. A pilot study.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Minimal residual disease in acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Real-time quantitation of minimal residual disease in inv(16)-positive acute myeloid leukemia may indicate risk for clinical relapse and may identify patients in a curable state

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Assessment of minimal residual disease (MRD) in CBFbeta/MYH11-positive acute myeloid leukemias by qualitative and quantitative RT-PCR amplification of fusion transcripts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular genetics of acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Preliminary experience in external quality control of RT-PCR PML-RAR alpha detection in promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cytogenetic characterization and clinical relevance of additional, complex and/or variant chromosome abnormalities in acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular monitoring of hematologic malignancies: current and future issues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402721

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.LEU.2402721

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

0 references

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