(Q34928276)

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The novel highly lipophilic topoisomerase I inhibitor DB67 is effective in the treatment of liver metastases of murine CT-26 colon carcinoma.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

The novel highly lipophilic topoisomerase I inhibitor DB67 is effective in the treatment of liver metastases of murine CT-26 colon carcinoma (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Lluis A Lopez-Barcons

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

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Junhong Zhang

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Gunching Siriwitayawan

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Thomas G Burke

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Roman Perez-Soler

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

publication date

1 September 2004

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

457-467

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Development and characterization of a novel liposome-based formulation of SN-38.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Impact of body-size measures on irinotecan clearance: alternative dosing recommendations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Potent topoisomerase I inhibition by novel silatecans eliminates glioma proliferation in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Extending principles learned in model systems to clinical trials design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Phase II trial of irinotecan in patients with metastatic colorectal carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

The chemotherapy of colon cancer can no longer be ignored

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

DNA topoisomerase poisons as antitumor drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

The S-phase cytotoxicity of camptothecin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

8 July 2018

Stability of irinotecan hydrochloride in aqueous solutions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

26 October 2018

The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

26 October 2018

A primary tumor promotes dormancy of solitary tumor cells before inhibiting angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1531650

26 October 2018

Reduced Albumin Binding Promotes the Stability and Activity of Topotecan in Human Blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with 125 I-5-iodo-2'-deoxyuridine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liposomes with prolonged circulation times: factors affecting uptake by reticuloendothelial and other tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental antitumor activity and pharmacokinetics of the camptothecin analog irinotecan (CPT-11) in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simple and versatile high-performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of camptothecin anticancer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-tumor activity of CPT-11 in experimental human ovarian cancer and human soft-tissue sarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Fluorouracil (5-FU) continuous intravenous infusion compared with bolus administration. Final results of a randomised trial in metastatic colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of liposomalization on the antitumor activity, side-effects and tissue distribution of CPT-11

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal models for studying the action of topoisomerase I targeted drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel A,B,E-ring-modified camptothecins displaying high lipophilicity and markedly improved human blood stabilities

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and antitumor activity of epirubicin encapsulated in long-circulating liposomes incorporating a polyethylene glycol-derivatized phospholipid

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid bilayer partitioning and stability of camptothecin drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural basis of camptothecin interactions with human serum albumin: impact on drug stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Marked interspecies variations concerning the interactions of camptothecin with serum albumins: a frequency-domain fluorescence spectroscopic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/15548354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1593/NEO.04139

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15548354%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

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