(Q34932506)

5 August 2017

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title

Protein palmitoylation: a regulator of neuronal development and function (English)

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5 August 2017

author name string

Alaa el-Din el-Husseini

series ordinal

1

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5 August 2017

David S Bredt

series ordinal

2

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5 August 2017

language of work or name

English

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publication date

1 October 2002

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Nature Reviews Neuroscience

5 August 2017

published in

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5 August 2017

volume

3

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5 August 2017

issue

10

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5 August 2017

page(s)

791-802

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Lipid modifications of G proteins

5 August 2017

cites work

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Signalling functions of protein palmitoylation

31 March 2020

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Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

31 March 2020

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Acylation of proteins with myristic acid occurs cotranslationally

31 March 2020

1 reference

Genetic and biochemical studies of protein N-myristoylation

31 March 2020

1 reference

Protein prenylation: molecular mechanisms and functional consequences

31 March 2020

1 reference

Two classes of fatty acid acylated proteins exist in eukaryotic cells.

31 March 2020

1 reference

Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species

31 March 2020

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The dynamic role of palmitoylation in signal transduction

31 March 2020

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Reversible palmitoylation of signaling proteins

31 March 2020

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Protein modification. Palmitoylation in G-protein signaling pathways

31 March 2020

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Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide

31 March 2020

1 reference

Identification of a palmitic acid-modified form of human Sonic hedgehog

31 March 2020

1 reference

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

31 March 2020

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The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS

31 March 2020

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The mechanism and functional roles of protein palmitoylation in the nervous system

31 March 2020

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N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4.

31 March 2020

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Primary structure and function of an A kinase anchoring protein associated with calcium channels

31 March 2020

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Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters.

31 March 2020

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Palmitoylation of G-protein-coupled receptors: a dynamic modification with functional consequences.

31 March 2020

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The G protein alpha s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification

31 March 2020

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Lipid modifications of G proteins: alpha subunits are palmitoylated

31 March 2020

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Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae

31 March 2020

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Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae

31 March 2020

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All ras proteins are polyisoprenylated but only some are palmitoylated

31 March 2020

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Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43.

31 March 2020

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Biochemical Characterization of a Palmitoyl Acyltransferase Activity That Palmitoylates Myristoylated Proteins

31 March 2020

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G-protein palmitoyltransferase activity is enriched in plasma membranes

31 March 2020

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Purification and biochemical characterization of a protein-palmitoyl acyltransferase from human erythrocytes

31 March 2020

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p260/270 expressed in embryonic abdominal leg cells of Bombyx mori can transfer palmitate to peptides

31 March 2020

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Purification of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide

31 March 2020

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Acylation in vitro of the myelin proteolipid protein and comparison with acylation in vivo: acylation of a cysteine occurs nonenzymatically

31 March 2020

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Pseudo-enzymatic S-acylation of a myristoylated yes protein tyrosine kinase peptide in vitro may reflect non-enzymatic S-acylation in vivo

31 March 2020

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Autoacylation of G protein alpha subunits

31 March 2020

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Acyl-CoA binding proteins inhibit the nonenzymic S-acylation of cysteinyl-containing peptide sequences by long-chain acyl-CoAs

31 March 2020

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An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development

31 March 2020

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Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins

31 March 2020

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Receptor regulation of G-protein palmitoylation

31 March 2020

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Analysis of the palmitoylation and membrane targeting domain of neuromodulin (GAP-43) by site-specific mutagenesis

31 March 2020

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Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering

31 March 2020

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Synaptic strength regulated by palmitate cycling on PSD-95.

31 March 2020

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Palmitoylation of GAP-43 by the ER-Golgi intermediate compartment and Golgi apparatus

31 March 2020

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Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3.

31 March 2020

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Binding of acylated peptides and fatty acids to phospholipid vesicles: pertinence to myristoylated proteins

31 March 2020

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Functional rafts in cell membranes

31 March 2020

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N-terminal protein acylation confers localization to cholesterol, sphingolipid-enriched membranes but not to lipid rafts/caveolae

31 March 2020

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Caveolae, transmembrane signalling and cellular transformation

31 March 2020

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The caveolae membrane system

31 March 2020

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Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior

31 March 2020

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GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

31 March 2020

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Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction

31 March 2020

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The N-terminal PDZ-containing region of postsynaptic density-95 mediates association with caveolar-like lipid domains

31 March 2020

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Association of GAP-43 with detergent-resistant membranes requires two palmitoylated cysteine residues

31 March 2020

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Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells

31 March 2020

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Tyrosine kinase receptors concentrated in caveolae-like domains from neuronal plasma membrane

31 March 2020

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Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture

31 March 2020

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Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes

31 March 2020

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Polarized sorting of glypiated proteins in hippocampal neurons

31 March 2020

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Neuronal polarity: essential role of protein-lipid complexes in axonal sorting

31 March 2020

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Polarized targeting of peripheral membrane proteins in neurons

31 March 2020

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G0 is a major growth cone protein subject to regulation by GAP-43.

31 March 2020

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GAP-43: an intrinsic determinant of neuronal development and plasticity

31 March 2020

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A membrane-targeting signal in the amino terminus of the neuronal protein GAP-43.

31 March 2020

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Palmitoylation alters protein activity: blockade of G(o) stimulation by GAP-43.

31 March 2020

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Dynamic palmitoylation of neuromodulin (GAP-43) in cultured rat cerebellar neurons and mouse N1E-115 cells

31 March 2020

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A shift in protein S-palmitoylation, with persistence of growth-associated substrates, marks a critical period for synaptic plasticity in developing brain

31 March 2020

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Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis

31 March 2020

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Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi cisternae

31 March 2020

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Multiple palmitoylation of synaptotagmin and the t-SNARE SNAP-25

31 March 2020

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Cysteine-string protein: the chaperone at the synapse

31 March 2020

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Synaptobrevin 2 is palmitoylated in synaptic vesicles prepared from adult, but not from embryonic brain.

31 March 2020

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31 March 2020

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Heptahelical receptor signaling: beyond the G protein paradigm.

31 March 2020

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Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit

31 March 2020

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Activation and depalmitoylation of Gs alpha

31 March 2020

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The stoichiometry of G alpha(s) palmitoylation in its basal and activated states

31 March 2020

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Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits

31 March 2020

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The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization

31 March 2020

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The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation

31 March 2020

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Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10

31 March 2020

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Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6

31 March 2020

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Signal-processing machines at the postsynaptic density

31 March 2020

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Interaction of ion channels and receptors with PDZ domain proteins

31 March 2020

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PDZ domains in synapse assembly and signalling

31 March 2020

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PDZ domains and the organization of supramolecular complexes

31 March 2020

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PDZ proteins organize synaptic signaling pathways

31 March 2020

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PDZ protein interactions regulating glutamate receptor function and plasticity

31 March 2020

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The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein

31 March 2020

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GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules

31 March 2020

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Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A

31 March 2020

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Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

31 March 2020

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Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins

31 March 2020

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PSD-95 and SAP97 exhibit distinct mechanisms for regulating K(+) channel surface expression and clustering

31 March 2020

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Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs

31 March 2020

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Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein

31 March 2020

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Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein.

31 March 2020

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SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo

31 March 2020

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Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs.

31 March 2020

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Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway

31 March 2020

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Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms

31 March 2020

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GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

31 March 2020

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Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP

31 March 2020

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Differential palmitoylation of two mouse glutamate receptor interacting protein 1 forms with different N-terminal sequences

31 March 2020

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Calcium Channels in Excitable Cell Membranes

31 March 2020

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Calcium channels in vertebrate cells

31 March 2020

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Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function.

31 March 2020

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The amino terminus of a calcium channel beta subunit sets rates of channel inactivation independently of the subunit's effect on activation

31 March 2020

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Unique regulatory properties of the type 2a Ca2+ channel beta subunit caused by palmitoylation

31 March 2020

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The role of dynamic palmitoylation in Ca2+ channel inactivation

31 March 2020

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Voltage-dependent potentiation of L-type Ca2+ channels due to phosphorylation by cAMP-dependent protein kinase

31 March 2020

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Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels

31 March 2020

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LTP mechanisms: from silence to four-lane traffic

31 March 2020

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Long-term potentiation--a decade of progress?

31 March 2020

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Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

31 March 2020

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The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit.

31 March 2020

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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

31 March 2020

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Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids.

31 March 2020

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Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

31 March 2020

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A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS)

31 March 2020

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Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca(2+)-calmodulin

31 March 2020

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Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN940

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Dimensions Publication ID

5 August 2017

1039859112

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