(Q34960765)

5 August 2017

title

A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins (English)

1 reference

5 August 2017

5

Richard R Neubig

1 reference

5 August 2017

Levi L Blazer

1

1 reference

5 August 2017

Haoming Zhang

series ordinal

2

1 reference

5 August 2017

Emma M Casey

series ordinal

3

1 reference

5 August 2017

Stephen M Husbands

series ordinal

4

1 reference

5 August 2017

language of work or name

English

0 references

publication date

29 March 2011

1 reference

5 August 2017

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5 August 2017

volume

50

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5 August 2017

issue

15

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5 August 2017

page(s)

3181-3192

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describes a project that uses

5 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3090679/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Regulators of G protein signaling proteins as targets for drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Teaching old receptors new tricks: biasing seven-transmembrane receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Use of flow cytometric methods to quantify protein-protein interactions.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: current status and future directions.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Allosteric modulation of kinases and GPCRs: design principles and structural diversity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Regulator of G protein signaling proteins: novel multifunctional drug targets

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Gastric acid secretion: activation and inhibition.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Expression of G-protein alpha subunits in Escherichia coli.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3090679

Recruitment of RGS2 and RGS4 to the plasma membrane by G proteins and receptors reflects functional interactions

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21329361

12 December 2020

inferred from PubMed ID database lookup

The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21329361

12 December 2020

inferred from PubMed ID database lookup

A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21329361

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1021/BI1019622

1 reference

5 August 2017

1 reference

5 August 2017

1 reference