(Q34974860)

5 August 2017

1 reference

title

Novel therapies in development for the treatment of traumatic brain injury (English)

1 reference

5 August 2017

traumatic brain injury

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author name string

Robert Vink

series ordinal

1

1 reference

PubMed ID

12387701

5 August 2017

Alan J Nimmo

series ordinal

2

1 reference

PubMed ID

12387701

5 August 2017

language of work or name

English

0 references

publication date

1 October 2002

1 reference

Expert Opinion on Investigational Drugs

5 August 2017

1 reference

5 August 2017

11

1 reference

5 August 2017

10

1 reference

5 August 2017

1375-1386

1 reference

Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998.

5 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Clinical neuro-protection trials in severe traumatic brain injury: lessons from previous studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Neuroprotective agents in traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Clinical trials in head injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Neuroprotection and traumatic brain injury: the search continues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Traumatic brain injury: developmental differences in glutamate receptor response and the impact on treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Factors affecting excitatory amino acid release following severe human head injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

21 January 2018

Excitotoxic cell death

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

The regulation of cytosolic calcium in rat brain synaptosomes by sodium-dependent calcium efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Inositol phosphates and cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Traumatic brain axonal injury produces sustained decline in intracellular free magnesium concentration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Magnetic resonance spectroscopy of diffuse brain trauma in the pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Evidence that intracellular magnesium is present in cells at a regulatory concentration for protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Magnesium: Nature's physiologic calcium blocker

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Free radical pathways in CNS injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Importance of pharmacologic considerations in the evaluation of new treatments for acute spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Mitochondrial participation in ischemic and traumatic neural cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Mitochondrial metabolism following traumatic brain injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Traumatic brain injury-induced changes in gene expression and functional activity of mitochondrial cytochrome C oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Severe head injury in children: impact of risk factors on outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Contribution of vasogenic and cellular edema to traumatic brain swelling measured by diffusion-weighted imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Magnesium deficiency exacerbates and pretreatment improves outcome following traumatic brain injury in rats: 31P magnetic resonance spectroscopy and behavioral studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Effect of magnesium given 1 hour after head trauma on brain edema and neurological outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Magnesium sulphate improves neurologic outcome following severe closed head injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Magnesium and ketamine attenuate cognitive dysfunction following experimental brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Preoperative regimens of magnesium facilitate recovery of function and prevent subcortical atrophy following lesions of the rat sensorimotor cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Improved motor outcome in response to magnesium therapy received up to 24 hours after traumatic diffuse axonal brain injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Development of prolonged focal cerebral edema and regional cation changes following experimental brain injury in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Postinjury treatment with magnesium chloride attenuates cortical damage after traumatic brain injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Survival and histological evaluation of therapeutic window of post-ischemia treatment with magnesium sulfate in embolic stroke model of rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Acute cytoskeletal alterations and cell death induced by experimental brain injury are attenuated by magnesium treatment and exacerbated by magnesium deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Suppression of cortical spreading depressions after magnesium treatment in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Neuroprotective effect of magnesium on lipid peroxidation and axonal function after experimental spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Oxygen free radical generation during in-utero hypoxia in the fetal guinea pig brain: the effects of maturity and of magnesium sulfate administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Ca2+-stimulated mitochondrial reactive oxygen species generation and permeability transition are inhibited by dibucaine or Mg2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Effects of nimodipine and magnesium sulfate on endogenous antioxidant levels in brain tissue after experimental head trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experimental head trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Magnesium in cell proliferation and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Expression of Bax and Bcl-2 proteins during hypoxia in cerebral cortical neuronal nuclei of newborn piglets: effect of administration of magnesium sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Postinjury magnesium treatment attenuates traumatic brain injury-induced cortical induction of p53 mRNA in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Post-hypoxic magnesium decreases nuclear oxidative damage in the fetal guinea pig brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Magnesium sulfate reverses experimental delayed cerebral vasospasm after subarachnoid hemorrhage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Magnesium sulphate reverses the carotid vasoconstriction caused by endothelin-I, angiotensin II and neuropeptide-Y, but not that caused by NG-nitro-L-arginine methyl ester, in conscious rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Assessment of the effects of endothelin-1 and magnesium sulphate on regional blood flows in conscious rats, by the coloured microsphere reference technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Alteration of substance P after trauma to the spinal cord: an experimental study in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Substance P receptor binding sites are expressed by glia in vivo after neuronal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Neurogenic inflammation in rat trachea is accompanied by increased negativity of interstitial fluid pressure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Neurokinin-1 receptor antagonist SR140333: a novel type of drug to treat cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Role of tachykinin NK receptors on the local and remote injuries following ischaemia and reperfusion of the superior mesenteric artery in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Neurokinin-1 expression and co-localization with glutamate and GABA in the hypothalamus of the cat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Distinct regulations by septide and the neurokinin-1 tachykinin receptor agonist [pro9]substance P of the N-methyl-D-aspartate-evoked release of dopamine in striosome- and matrix-enriched areas of the rat striatum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Substance P increases release of acetylcholine in the dorsal striatum of freely moving rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Substance P opens cation channels and closes potassium channels in rat locus coeruleus neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Selective blockade of substance P or neurokinin A receptors reduces the expression of c-fos in trigeminal subnucleus caudalis after corneal stimulation in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Cyclosporin A protects against ischemia-reperfusion injury in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Postinjury cyclosporin A administration limits axonal damage and disconnection in traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Involvement of apoptosis in neurological injury after hypothermic circulatory arrest: a new target for therapeutic intervention?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

The immunophilin ligand FK506 attenuates axonal injury in an impact-acceleration model of traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Dose-response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

A nonpsychotropic cannabinoid, HU-211, has cerebroprotective effects after closed head injury in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Treatment with the thyrotropin-releasing hormone analog CG3703 restores magnesium homeostasis following traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Effects of nalmefene, CG3703, tirilazad, or dopamine on cerebral blood flow, oxygen delivery, and electroencephalographic activity after traumatic brain injury and hemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Neurosurgical trauma in Japan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Neuroprotective effects of combination therapy with tirilazad and magnesium in rats subjected to reversible focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Sequential pharmacotherapy with magnesium chloride and basic fibroblast growth factor after fluid percussion brain injury results in less neuromotor efficacy than that achieved with magnesium alone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

Abnormal substance P release from the spinal cord following injury to primary sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.10.1375

10.1517/13543784.11.10.1375

21 January 2018

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12387701