(Q34976859)

5 August 2017

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title

Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules (English)

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5 August 2017

Gilda Tachedjian

2

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Nicolas Sluis-Cremer

series ordinal

1

object named as

Nicolas Sluis-Cremer

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5 August 2017

language of work or name

English

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publication date

1 November 2002

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5 August 2017

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5 August 2017

volume

269

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5 August 2017

issue

21

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5 August 2017

page(s)

5103-5111

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describes a project that uses

5 August 2017

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Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

New antiretroviral agents: looking beyond protease and reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Potential new therapies for the treatment of HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Dimerization of cell surface receptors in signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Inhibiting the assembly of protein-protein interfaces.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Inhibition of HIV protease activity by heterodimer formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

HIV-1 reproduction is inhibited by peptides derived frm the N- and C-termini of HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

The inhibition of human immunodeficiency virus proteases by 'interface peptides'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Lipopeptides as dimerization inhibitors of HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Design, synthesis, and evaluation of conformationally constrained tongs, new inhibitors of HIV-1 protease dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Design and synthesis of new inhibitors of HIV-1 protease dimerization with conformationally constrained templates

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Targeting the dimerization interface for irreversible inhibition of HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

A modular approach to HIV-1 proteinase inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Genetic selection for dissociative inhibitors of designated protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Triterpenes as potential dimerization inhibitors of HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

High resolution structures of HIV-1 RT from four RT-inhibitor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Functional characterization of chimeric reverse transcriptases with polypeptide subunits of highly divergent HIV-1 group M and O strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Conformational stability of dimeric HIV-1 and HIV-2 reverse transcriptases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Interface peptides as structure-based human immunodeficiency virus reverse transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

A new potent HIV-1 reverse transcriptase inhibitor. A synthetic peptide derived from the interface subunit domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Dimerization kinetics of HIV-1 and HIV-2 reverse transcriptase: a two step process

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

The thumb domain of the P51-subunit is essential for activation of HIV reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Solution structure of the N-terminal zinc binding domain of HIV-1 integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Solution structure of the DNA binding domain of HIV-1 integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Structure and assembly of the virion

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

HIV integrase structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

The structural stability of the HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

Peptide inhibitors of HIV-1 integrase dissociate the enzyme oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.03216.X

10.1046/J.1432-1033.2002.03216.X

21 January 2018

Identifiers

DOI

1 reference

5 August 2017

1 reference