(Q34978931)

5 August 2017

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title

Iron and carcinogenesis: from Fenton reaction to target genes (English)

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5 August 2017

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Shinya Toyokuni

1

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5 August 2017

publication date

1 January 2002

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5 August 2017

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5 August 2017

volume

7

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5 August 2017

issue

4

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5 August 2017

page(s)

189-197

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Iron-induced carcinogenesis: the role of redox regulation

5 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of 'catalytic' iron and anti-oxidant activity in extracellular fluids

21 January 2018

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Iron-mediated DNA damage: sensitive detection of DNA strand breakage catalyzed by iron

21 January 2018

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Non-ferritin, non-heme iron pools in rat tissues.

21 January 2018

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Low-Mr iron isolated from guinea pig reticulocytes as AMP-Fe and ATP-Fe complexes

21 January 2018

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A site-specific mechanism for free radical induced biological damage: the essential role of redox-active transition metals

21 January 2018

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https://api.crossref.org/works/10.1179%2F135100002125000596

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg

21 January 2018

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https://api.crossref.org/works/10.1179%2F135100002125000596

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

21 January 2018

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Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome

21 January 2018

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Ectopic expression of Nramp1 in COS-1 cells modulates iron accumulation

21 January 2018

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https://api.crossref.org/works/10.1179%2F135100002125000596

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

21 January 2018

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https://api.crossref.org/works/10.1179%2F135100002125000596

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

21 January 2018

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https://api.crossref.org/works/10.1179%2F135100002125000596

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

21 January 2018

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Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria

21 January 2018

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Frataxin: its role in iron metabolism and the pathogenesis of Friedreich's ataxia.

21 January 2018

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Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron

21 January 2018

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Identification of the iron-responsive element for the translational regulation of human ferritin mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron

21 January 2018

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The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake

21 January 2018

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Iron-dependent regulation of the divalent metal ion transporter

21 January 2018

1 reference

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A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA

21 January 2018

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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

21 January 2018

1 reference

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Nitrogen monoxide activates iron regulatory protein 1 RNA-binding activity by two possible mechanisms: effect on the [4Fe-4S] cluster and iron mobilization from cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Clinically overt hereditary hemochromatosis in Denmark 1948-1985: epidemiology, factors of significance for long-term survival, and causes of death in 179 patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Cancer risk following primary hemochromatosis: a population-based cohort study in Denmark.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Hereditary hemochromatosis and cancer risk: more fuel to the fire?

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Hepatocellular carcinoma in primary haemochromatosis in the absence of cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Induction of oxidative single- and double-strand breaks in DNA by ferric citrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Iron-induced tissue damage and cancer: the role of reactive oxygen species-free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Reactive oxygen species-induced molecular damage and its application in pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Specific allelic loss of p16 (INK4A) tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

LXXIII.—Oxidation of tartaric acid in presence of iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Superoxide-dependent formation of hydroxyl radicals from ferric-complexes and hydrogen peroxide: an evaluation of fourteen iron chelators

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Non-transferrin plasma iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Identification of transferrin receptors in reticulocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Comparative aspects of transferrin-reticulocyte interactions: membrane receptors and iron uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

An ATP-dependent iron transport system in isolated rat liver nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

High Incidence of Extrahepatic Carcinomas in Idiopathic Hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Pathogenesis of hepatocellular carcinoma in hereditary hemochromatosis: occurrence in noncirrhotic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

p53 mutations in british patients with hepatocellular carcinoma: clustering in genetic hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F135100002125000596

10.1179/135100002125000596

21 January 2018

Identifiers

DOI

1 reference

5 August 2017

1 reference