(Q34979570)

5 August 2017

title

Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling (English)

1 reference

5 August 2017

Anantha S Metlakunta

1

1 reference

5 August 2017

Maitrayee Sahu

2

1 reference

5 August 2017

Hideo Yasukawa

3

1 reference

5 August 2017

Sandeep S Dhillon

4

1 reference

5 August 2017

Denise D Belsham

5

1 reference

5 August 2017

Akihiko Yoshimura

6

1 reference

5 August 2017

Abhiram Sahu

7

1 reference

5 August 2017

publication date

16 February 2011

1 reference

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

5 August 2017

published in

1 reference

5 August 2017

volume

300

1 reference

5 August 2017

issue

5

1 reference

5 August 2017

page(s)

R1185-93

1 reference

Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance

5 August 2017

cites work

1 reference

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Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance

8 July 2018

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8 July 2018

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Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

LRb signals act within a distributed network of leptin-responsive neurones to mediate leptin action

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice

8 July 2018

1 reference

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Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function

8 July 2018

1 reference

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Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Hypothalamic mTOR signaling regulates food intake

8 July 2018

1 reference

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Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

PI3K integrates the action of insulin and leptin on hypothalamic neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Minireview: A hypothalamic role in energy balance with special emphasis on leptin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Leptin receptor signaling and the regulation of mammalian physiology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Intracellular signalling. Key enzyme in leptin-induced anorexia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

SOCS: physiological suppressors of cytokine signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Negative regulation of cytokine signaling pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Central nervous system control of food intake

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

The role of SOCS-3 in leptin signaling and leptin resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Leptin and the regulation of body weight in mammals

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Identification of SOCS-3 as a potential mediator of central leptin resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094031

Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons

8 July 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00794.2010

SOCS-3 expression in leptin-sensitive neurons of the hypothalamus of fed and fasted rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00794.2010

Divergent roles of SHP-2 in ERK activation by leptin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00794.2010

Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00794.2010

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00794.2010

Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00794.2010

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00794.2010

Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00794.2010

Leptin signaling in the hypothalamus during chronic central leptin infusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00794.2010

Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00794.2010

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21325649

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Leptin activates neurons in ventrobasal hypothalamus and brainstem

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21325649

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21325649

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1152/AJPREGU.00794.2010

1 reference

5 August 2017

1 reference

5 August 2017

1 reference