(Q34983258)

5 August 2017

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title

Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock (English)

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5 August 2017

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Peter De Paepe

1

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5 August 2017

Frans M Belpaire

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2

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5 August 2017

Walter A Buylaert

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3

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5 August 2017

language of work or name

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1 January 2002

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Clinical Pharmacokinetics

5 August 2017

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5 August 2017

41

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5 August 2017

14

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5 August 2017

1135-1151

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https://scigraph.springernature.com/pub.10.2165/00003088-200241140-00002

5 August 2017

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cites work

Differential alterations in microvascular perfusion in various organs during early and late sepsis

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12 December 2020

Pathogenetic mechanisms of septic shock

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12 December 2020

Comments to consensus document. Once-daily dosing of aminoglycosides from N. Anaizi. A supplement to dosage and monitoring in critically ill patients

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12 December 2020

Increasing splanchnic blood flow in the critically III.

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12 December 2020

Sepsis, the sepsis syndrome, multi-organ failure: a plea for comparable definitions

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12 December 2020

Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure

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12 December 2020

Evaluation of naloxone for therapy of Escherichia coli shock. Species differences

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12 December 2020

Effect of altered volume of distribution on aminoglycoside levels in patients in surgical intensive care

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12 December 2020

The association of aminoglycoside plasma levels with mortality in patients with gram-negative bacteremia.

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12 December 2020

Treating patients with severe sepsis

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12 December 2020

Hypoperfusion of the intestinal microcirculation without decreased cardiac output during live Escherichia coli sepsis in rats.

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12 December 2020

The pharmacological basis of treatment with high dose corticosteroids in circulatory shock

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12 December 2020

Clinical pharmacokinetics of antibiotics in patients with impaired renal function

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12 December 2020

Septic autocannibalism. A failure of exogenous nutritional support

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12 December 2020

Pharmacokinetics of antibiotics in critically ill patients.

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12 December 2020

Effect of a dopexamine-induced increase in cardiac index on splanchnic hemodynamics in septic shock

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12 December 2020

Regulation of the peripheral vasculature and tissue oxygenation in health and disease

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12 December 2020

Alterations in circulating blood volume during polymicrobial sepsis.

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12 December 2020

Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospective, randomized study

1 reference

12 December 2020

The influence of renal function on the renal clearance of morphine and its glucuronide metabolites in intensive‐care patients

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12 December 2020

Distribution of cardiac output, oxygen consumption and lactate production in canine endotoxin shock

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12 December 2020

Pharmacokinetics of drugs used in critically ill adults

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12 December 2020

Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat.

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12 December 2020

Pathophysiology of acute renal failure in septic shock: from prerenal to renal failure

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12 December 2020

Endotoxin-induced regional circulatory changes in the unanesthetized monkey

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12 December 2020

Altered aminoglycoside pharmacokinetics in the critically ill

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12 December 2020

Effect of dobutamine on oxygen consumption and gastric mucosal pH in septic patients.

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12 December 2020

Oxygen consumption in sepsis and septic shock

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12 December 2020

Relationship of serum gentamicin levels and methylprednisolone sodium succinate treatment in baboons challenged with Escherichia coli LD100

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12 December 2020

The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis.

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12 December 2020

The altered pharmacokinetics and pharmacodynamics of drugs commonly used in critically ill patients

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12 December 2020

Theophylline and ethylenediamine pharmacokinetics following administration of aminophylline to septic patients with multiorgan failure

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12 December 2020

Increase in National Hospital Discharge Survey rates for septicemia--United States, 1979-1987.

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12 December 2020

Pharmacokinetics of cefepime in patients with the sepsis syndrome

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12 December 2020

Sepsis/septic shock: participation of the microcirculation: an abbreviated review

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12 December 2020

Impaired beta-adrenergic receptor stimulation of cyclic adenosine monophosphate in human septic shock: association with myocardial hyporesponsiveness to catecholamines

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12 December 2020

Effects of surgery on the pharmacokinetic parameters of drugs

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12 December 2020

Does Hepato-splanchnic V˙o2/Do2Dependency Exist in Critically Ill Septic Patients?

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12 December 2020

Pharmacokinetic optimisation of the treatment of bacterial central nervous system infections.

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12 December 2020

Nitric oxide mediates hepatic cytochrome P450 dysfunction induced by endotoxin

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12 December 2020

The effect of endotoxin administration on the pharmacokinetics of chlorzoxazone in humans

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12 December 2020

Regulation of cytochromes P450 during inflammation and infection.

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12 December 2020

High-dose naloxone: pharmacokinetics in patients in septic shock

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12 December 2020

Circulatory and metabolic alterations associated with survival or death in peritonitis: clinical analysis of 25 cases

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12 December 2020

Effect of individualized pharmacokinetic dosing on patient outcome.

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12 December 2020

Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine

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12 December 2020

Gentamicin volume of distribution in critically ill septic patients

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12 December 2020

Prolonged sedation due to accumulation of conjugated metabolites of midazolam

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12 December 2020

The pharmacokinetics of intravenous ciprofloxacin 400 mg 12 hourly in patients with severe sepsis: the effect of renal function and intra-abdominal disease

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12 December 2020

Relationship between hemodynamic and vital support measures and pharmacokinetic variability of amikacin in critically ill patients with sepsis

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12 December 2020

Effect of injury and infection on visceral metabolism and circulation

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12 December 2020

A wake-up call in the intensive care unit

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12 December 2020

Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock

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12 December 2020

What changes drug metabolism in critically ill patients?--II Serum inhibits the metabolism of midazolam in human microsomes.

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12 December 2020

Regional blood flow and oxygen transport in septic shock

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12 December 2020

Interrelationship Between Renal Haemodynamics, Drug Kinetics and Drug Action

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12 December 2020

Pharmacokinetics of aztreonam in critically ill surgical patients.

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12 December 2020

The effects of low-dose dopamine on splanchnic blood flow and oxygen uptake in patients with septic shock.

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12 December 2020

Comparison of gastric intramucosal pH with measures of oxygen transport and consumption in critically ill patients

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12 December 2020

Effect of hepatic insufficiency on pharmacokinetics and drug dosing

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12 December 2020

Factors affecting gentamicin pharmacokinetics in septic patients

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12 December 2020

A rational basis for the measurement of free phenytoin concentration in critically ill trauma patients

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12 December 2020

Treatment of Septicemic Patients with Cefoxitin: Pharmacokinetics in Renal Insufficiency

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12 December 2020

Effectiveness of modified steroid-antibiotic therapies for lethal sepsis in the dog

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12 December 2020

A Dobutamine Test Can Disclose Hepatosplanchnic Hypoperfusion in Septic Patients

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12 December 2020

Gentamicin dosage requirements: wide interpatient variations in 242 surgery patients with normal renal function

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12 December 2020

Microvascular function and rheologic changes in hyperdynamic sepsis

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12 December 2020

Adequacy of gut oxygenation in endotoxemia and sepsis

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12 December 2020

Pharmacokinetics of opioids in renal dysfunction

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12 December 2020

The effect of various sympathomimetics on the regional circulations in hyperdynamic sepsis

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12 December 2020

Altered aminoglycoside pharmacokinetics in critically ill patients with sepsis

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12 December 2020

Pharmacotherapy in shock syndromes: the neglected field of pharmacokinetics and pharmacodynamics

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12 December 2020

Splanchnic and systemic hemodynamic responses to portal vein endotoxin after resuscitation from hemorrhagic shock.

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12 December 2020

Molecular mechanisms of drug metabolism in the critically ill.

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12 December 2020

Physiologic response of stress and aminoglycoside clearance in critically ill patients

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12 December 2020

Abnormal vascular tone, defective oxygen transport and myocardial failure in human septic shock

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12 December 2020

The contrasting effects of dobutamine and dopamine on gastric mucosal perfusion in septic patients

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12 December 2020

Gentamicin pharmacokinetics in 1,640 patients: method for control of serum concentrations

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12 December 2020

Protecting the gut and the liver in the critically ill: effects of dopexamine

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12 December 2020

Hepatic extraction of indocyanine green is depressed early in sepsis despite increased hepatic blood flow and cardiac output

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12 December 2020

Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women

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12 December 2020

Gastric intramucosal pH. A better predictor of multiorgan dysfunction syndrome and death than oxygen-derived variables in patients with sepsis

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12 December 2020

Effect of renal failure on drug metabolism by the liver

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12 December 2020

Aminoglycoside volume of distribution and illness severity in critically ill septic patients

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12 December 2020

Plasma and cerebrospinal fluid concentrations of morphine and morphine glucuronides after oral morphine. The influence of renal failure.

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12 December 2020

American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis

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12 December 2020

Serum protein binding of propofol in critically ill patients.

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12 December 2020

Profound reduction in morphine clearance and liver blood flow in shock

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12 December 2020

Population analysis of once-daily dosing of gentamicin in patients with neutropenia.

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12 December 2020

What changes drug metabolism in critically ill patients? Two preliminary studies in isolated human hepatocytes.

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12 December 2020

Splanchnic and total body oxygen consumption differences in septic and injured patients

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12 December 2020

Whole Body and Splanchnic Blood Flow and Oxygen Consumption Measurements in Patients with Intraperitoneal Infection

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12 December 2020

Multiple-dose pharmacokinetics of amikacin and ceftazidime in critically ill patients with septic multiple-organ failure during intermittent hemofiltration

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12 December 2020

Single-dose pharmacokinetics of oral fleroxacin in bacteremic patients

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12 December 2020

Pharmacokinetics of a 3 mg/kg body weight loading dose of gentamicin or tobramycin in critically ill patients

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12 December 2020

Modulation of drug metabolism in infectious and inflammatory diseases

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12 December 2020

Pharmacokinetics in acute illness

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12 December 2020

Changes in hepatic flow induced by continuous positive pressure ventilation in critically ill patients

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12 December 2020

Increase in hepatic blood flow during early sepsis is due to increased portal blood flow

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12 December 2020

Influence of positive end-expiratory pressure on left ventricular performance

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12 December 2020

Hepatocellular dysfunction occurs earlier than the onset of hyperdynamic circulation during sepsis.

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12 December 2020

Detection of capillary protein leakage by indocyanine green and glucose dilutions in septic patients

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12 December 2020

Pharmacokinetics and pharmacodynamics of sedatives and analgesics in the treatment of agitated critically ill patients

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12 December 2020

The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver

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12 December 2020

Pharmacokinetics and extravascular penetration of aztreonam in patients with abdominal sepsis.

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12 December 2020

Variability in aminoglycoside pharmacokinetics in critically ill surgical patients

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12 December 2020

Decreased hepatic clearance of clindamycin in critically ill patients with sepsis

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12 December 2020

Multiple organ failure syndrome in the 1990s. Systemic inflammatory response and organ dysfunction

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12 December 2020

Adjunctive drug treatment in severe hypoxic respiratory failure.

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12 December 2020

Alternations in liver hemodynamics in an intact porcine model of endotoxin shock

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12 December 2020

Failure of critically ill patients to metabolise midazolam.

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12 December 2020

Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism

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12 December 2020

Pharmacokinetics and pharmacodynamics in the critically ill patient

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12 December 2020

Epidemiology of sepsis syndrome in 8 academic medical centers

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12 December 2020

Pharmacokinetic and pharmacodynamic considerations in drug therapy of cardiac emergencies

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12 December 2020

What changes drug metabolism in critically ill patients--III? Effect of pre-existing disease on the metabolism of midazolam.

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12 December 2020

Decreased plasma albumin concentration results in increased volume of distribution and decreased elimination of midazolam in intensive care patients.

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12 December 2020

Hepatocellular function and nutrient blood flow in experimental peritonitis

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12 December 2020

Epinephrine impairs splanchnic perfusion in septic shock.

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12 December 2020

Hepatic drug metabolism in critical illness

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12 December 2020

Pharmacokinetic profiles of high-dose intravenous ciprofloxacin in severe sepsis. The Baragwanath Ciprofloxacin Study Group

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12 December 2020

Physiologic implications of mechanical ventilation on pharmacokinetics

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12 December 2020

Aminoglycoside volume of distribution in postoperative patients with septic shock

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12 December 2020

10.2165/00003088-200241140-00002

Identifiers

DOI

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Dimensions Publication ID

5 August 2017

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