(Q34984650)

English

Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

author name string

Ying Xiong

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Hai-Ting Lu

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Yongjian Li

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Guang-Fu Yang

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Chang-Guo Zhan

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

0 references

publication date

1 September 2006

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Biophysical Journal

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Europe PubMed Central

PubMed publication ID

5 August 2017

91

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1858-1867

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

describes a project that uses

molecular dynamics simulation

1 reference

based on heuristic

inferred from title

Phosphodiesterase-4 as a potential drug target

1 reference

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Effect of Zn...Zn separation on the hydrolytic activity of model dizinc phosphodiesterases

1 reference

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Selective phosphodiesterase-4 inhibitors in chronic obstructive lung disease

1 reference

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Structural basis for the activity of drugs that inhibit phosphodiesterases

1 reference

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A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

1 reference

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The impact of sildenafil on molecular science and sexual health

1 reference

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Cardioprotection with phosphodiesterase-5 inhibition--a novel preconditioning strategy.

1 reference

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Phosphodiesterase 5 inhibitors in rapid ejaculation: potential use and possible mechanisms of action.

1 reference

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8 July 2018

Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity

1 reference

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Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

1 reference

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A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4

1 reference

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Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization

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Therapeutic potential of phosphodiesterase 5 inhibition for cardiovascular disease

1 reference

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8 July 2018

Cyclic nucleotide phosphodiesterase 5 and sildenafil: promises realized

1 reference

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8 July 2018

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

1 reference

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8 July 2018

Crystal structure of phosphodiesterase 4D and inhibitor complex(1)

1 reference

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8 July 2018

Phosphodiesterase 5 inhibitors: current status and potential applications

1 reference

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Reevaluating the role of phosphodiesterase inhibitors in the treatment of cardiovascular disease.

1 reference

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Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats

1 reference

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PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle

1 reference

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Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling.

1 reference

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Cyclic AMP specific phosphodiesterase activity and colon cancer cell motility

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Cyclic nucleotide phosphodiesterases: relating structure and function

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8 July 2018

A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity

1 reference

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Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

1 reference

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Antithrombotic activity of NSP-513, a novel selective phosphodiesterase 3 inhibitor, on femoral arterial thrombosis induced by physical stenosis and electrical current: comparison of antithrombotic and hemodynamic effects

1 reference

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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

1 reference

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Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors

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The molecular biology of cyclic nucleotide phosphodiesterases.

1 reference

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Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives

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Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density

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The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions

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Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?

1 reference

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Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)

1 reference

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A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity

1 reference

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8 July 2018

Hormonal regulation of cyclic nucleotide phosphodiesterases

1 reference

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The Protein Data Bank: a computer-based archival file for macromolecular structures

1 reference

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Cyclic GMP and phosphodiesterase 5 inhibitor therapies: what's on the horizon?

1 reference

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Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction

1 reference

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Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity

1 reference

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Geometry optimization with QM/MM, ONIOM, and other combined methods. I. Microiterations and constraints.

1 reference

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Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle

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Coordination number of zinc ions in the phosphotriesterase active site by molecular dynamics and quantum mechanics

1 reference

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Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat.

1 reference

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Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor.

1 reference

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Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones

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1 reference

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First computational evidence for a catalytic bridging hydroxide ion in a phosphodiesterase active site.

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Mobility of the active site bound paraoxon and sarin in zinc-phosphotriesterase by molecular dynamics simulation and quantum chemical calculation

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1 reference

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Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphodiesterases: the journey towards therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Arylnaphthalene lignan: a novel scaffold for type 5 phosphodiesterase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1529/BIOPHYSJ.106.086835

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

0 references

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