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Two-state reactivity mechanisms of hydroxylation and epoxidation by cytochrome P-450 revealed by theory.
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Europe PubMed Central
PubMed publication ID
12413538
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
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14 December 2019
review article
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title
Two-state reactivity mechanisms of hydroxylation and epoxidation by cytochrome P-450 revealed by theory
(English)
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Europe PubMed Central
PubMed publication ID
12413538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
author
Helmut Schwarz
series ordinal
4
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Europe PubMed Central
PubMed publication ID
12413538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
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14 December 2019
author name string
Sason Shaik
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1
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Europe PubMed Central
PubMed publication ID
12413538
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
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14 December 2019
Samuël P de Visser
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2
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Europe PubMed Central
PubMed publication ID
12413538
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
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14 December 2019
François Ogliaro
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3
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Europe PubMed Central
PubMed publication ID
12413538
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
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14 December 2019
Detlef Schröder
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5
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Europe PubMed Central
PubMed publication ID
12413538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
publication date
1 October 2002
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Europe PubMed Central
PubMed publication ID
12413538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
published in
Current Opinion in Chemical Biology
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Europe PubMed Central
PubMed publication ID
12413538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
volume
6
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Europe PubMed Central
PubMed publication ID
12413538
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
issue
5
1 reference
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Europe PubMed Central
PubMed publication ID
12413538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
page(s)
556-567
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Europe PubMed Central
PubMed publication ID
12413538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
cites work
Heme-Containing Oxygenases
1 reference
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7 January 2021
based on heuristic
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Probing Structure-Function Relations in Heme-Containing Oxygenases and Peroxidases
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cytochrome P-450 catalysis: radical intermediates and dehydrogenation reactions
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypersensitive radical probes and the mechanisms of cytochrome P450-catalyzed hydroxylation reactions
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
How Does Ethene Inactivate Cytochrome P450 En Route to Its Epoxidation? A Density Functional Study The research is supported in part by the ISF and in part by the Ministry of Science, Culture, and Sport. F.O. acknowledges the European Union for a Ma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multi-state epoxidation of ethene by cytochrome P450: a quantum chemical study
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Stereospecific oxidation by compound I of cytochrome P450 does not proceed in a concerted synchronous manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic Isotope Effects in a C−H Bond Dissociation by the Iron-Oxo Species of Cytochrome P450
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A theoretical study of the dynamic behavior of alkane hydroxylation by a compound I model of cytochrome P450.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemistry of excited electronic States
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7 January 2021
based on heuristic
inferred from DOI database lookup
Two-state reactivity as a new concept in organometallic chemistry
1 reference
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https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
retrieved
7 January 2021
based on heuristic
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Two-State Reactivity in the Rebound Step of Alkane Hydroxylation by Cytochrome P-450: Origins of Free Radicals with Finite Lifetimes This research was sponsored by the Israeli Science Foundation (ISF) and, in part, by the German Israeli Foundation (
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the heme active site and protein environment in structure, spectra, and function of the cytochrome p450s
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
High-valent intermediates of heme proteins and model compounds
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
The High-Valent Compound of Cytochrome P450: The Nature of the Fe-S Bond and the Role of the Thiolate Ligand as an Internal Electron Donor
1 reference
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Crossref
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7 January 2021
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Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monoxygenase system
1 reference
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
What factors affect the regioselectivity of oxidation by cytochrome p450? A DFT study of allylic hydroxylation and double bond epoxidation in a model reaction
1 reference
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Crossref
reference URL
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7 January 2021
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On the "Rebound" Mechanism of Alkane Hydroxylation by Cytochrome P450: Electronic Structure of the Intermediate and the Electron Transfer Character in the Rebound Step
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
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7 January 2021
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inferred from DOI database lookup
Cytochrome P450-catalyzed hydroxylation of hydrocarbons: kinetic deuterium isotope effects for the hydroxylation of an ultrafast radical clock.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
On the Origin of the Low-Spin Character of Cytochrome P450cam in the Resting State-Investigations of Enzyme Models with Pulse EPR and ENDOR Spectroscopy
1 reference
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Crossref
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7 January 2021
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Searching for the second oxidant in the catalytic cycle of cytochrome P450: a theoretical investigation of the iron(III)-hydroperoxo species and its epoxidation pathways
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Revisiting the mechanism of P450 enzymes with the radical clocks norcarane and spiro[2,5]octane
1 reference
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7 January 2021
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inferred from DOI database lookup
Synthetic active site analogues of heme-thiolate proteins. Characterization and identification of intermediates of the catalytic cycles of cytochrome P450cam and chloroperoxidase
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
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1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
The elusive oxidant species of cytochrome P450 enzymes: characterization by combined quantum mechanical/molecular mechanical (QM/MM) calculations
1 reference
stated in
Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Evidence for two different active oxygen species in cytochrome P450 BM3 mediated sulfoxidation and N-dealkylation reactions
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hydroxylation of camphor by reduced oxy-cytochrome P450cam: mechanistic implications of EPR and ENDOR studies of catalytic intermediates in native and mutant enzymes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900363-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Experimental evidence for multiple oxidation pathways in the (salen) Mn-catalyzed epoxidation of alkenes
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1367-5931(02)00363-0
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12413538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
PubMed publication ID
12413538
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12413538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413538%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
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