(Q34991901)

5 August 2017

title

The role of small molecules in bone regeneration (English)

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5 August 2017

Qian-Qian Han

1

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5 August 2017

Yi Du

series ordinal

2

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5 August 2017

Pi-Shan Yang

series ordinal

3

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5 August 2017

publication date

1 September 2013

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Future Medicinal Chemistry

5 August 2017

published in

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5 August 2017

volume

5

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5 August 2017

issue

14

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5 August 2017

page(s)

1671-1684

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Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy

5 August 2017

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Bone marrow stromal cells with a combined expression of BMP-2 and VEGF-165 enhanced bone regeneration

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Preclinical investigation of PEGylated tumor necrosis factor alpha in dogs with spontaneous tumors: phase I evaluation

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An injectable method for noninvasive spine fusion

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Vertebral osteolysis after posterior interbody lumbar fusion with recombinant human bone morphogenetic protein 2: a report of five cases

21 January 2018

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Platelet-derived growth factor promotes periodontal regeneration in localized osseous defects: 36-month extension results from a randomized, controlled, double-masked clinical trial

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Chemical genetics to chemical genomics: small molecules offer big insights

21 January 2018

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High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth

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Chemical control of stem cell fate and developmental potential

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21 January 2018

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Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells.

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Quercetin improves bone strength in experimental biliary cirrhosis.

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A naturally occurring rare analog of quercetin promotes peak bone mass achievement and exerts anabolic effect on osteoporotic bone.

21 January 2018

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A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: the role of aryl hydrocarbon receptor as a mediator of osteogenic action.

21 January 2018

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Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell

21 January 2018

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Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells.

21 January 2018

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Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation

21 January 2018

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21 January 2018

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Hesperidin inhibits ovariectomized-induced osteopenia and shows differential effects on bone mass and strength in young and adult intact rats.

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Poncirin promotes osteoblast differentiation but inhibits adipocyte differentiation in mesenchymal stem cells

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Anthraquinone compounds from Morinda officinalis inhibit osteoclastic bone resorption in vitro

21 January 2018

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Emodin accelerates osteoblast differentiation through phosphatidylinositol 3-kinase activation and bone morphogenetic protein-2 gene expression

21 January 2018

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Emodin-8-O-β-D-glucoside from Polygonum amplexicaule D. Don var. sinense Forb. promotes proliferation and differentiation of osteoblastic MC3T3-E1 cells.

21 January 2018

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Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?

21 January 2018

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Thymoquinone accelerates osteoblast differentiation and activates bone morphogenetic protein-2 and ERK pathway

21 January 2018

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Bone defects in LPA receptor genetically modified mice

21 January 2018

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Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.

21 January 2018

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Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

21 January 2018

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Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

21 January 2018

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Glycogen synthase kinase-3 beta inhibitor suppresses Porphyromonas gingivalis lipopolysaccharide-induced CD40 expression by inhibiting nuclear factor-kappa B activation in mouse osteoblasts

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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

21 January 2018

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Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

21 January 2018

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GSK-3 inhibition by an orally active small molecule increases bone mass in rats

21 January 2018

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The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

21 January 2018

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A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation

21 January 2018

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(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate.

21 January 2018

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Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

21 January 2018

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Effects of ONO-5334, a novel orally-active inhibitor of cathepsin K, on bone metabolism.

21 January 2018

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Potential role of odanacatib in the treatment of osteoporosis

21 January 2018

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Pyridone 6, a pan-Janus-activated kinase inhibitor, suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.133

Coptisine inhibits RANKL-induced NF-κB phosphorylation in osteoclast precursors and suppresses function through the regulation of RANKL and OPG gene expression in osteoblastic cells.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

A novel small molecule, NecroX-7, inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1.

21 January 2018

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The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage

21 January 2018

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Determination of a novel TAZ modulator, 2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H imidazo[4,5-b]pyridine] (TM-25659) in rat plasma by liquid chromatography-tandem mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Identification of upregulators of BMP2 expression via high-throughput screening of a synthetic and natural compound library

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis: involvement in Smad activation and NF-κB inhibition.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads

21 January 2018

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Development and optimization of a cell-based assay for the selection of synthetic compounds that potentiate bone morphogenetic protein-2 activity

21 January 2018

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A synthetic compound that potentiates bone morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype

21 January 2018

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The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.

21 January 2018

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Small-molecule inhibitors of the HIF pathway and synthetic lethal interactions

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Mevinolin enhances osteogenic genes (ALP, type I collagen and osteocalcin), CD44, CD47 and CD51 expression during osteogenic differentiation

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: part 2. Synthesis of rigid pyrazolones.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Synthesis and discovery of novel pyrazole carboxamide derivatives as potential osteogenesis inducers

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Osteopromotive activity of a novel pyrazole carboxamide derivative

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Synthetic analogs of daidzein, having more potent osteoblast stimulating effect

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Denervation impairs bone regeneration during distraction osteogenesis in rabbit tibia lengthening

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.133

Hydrocortisone stimulates neurite outgrowth from mouse retinal explants by modulating macroglial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.133

A small molecule approach to engineering vascularized tissue.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

Poncirin prevents bone loss in glucocorticoid-induced osteoporosis in vivo and in vitro

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.133

21 January 2018

Identifiers

DOI

10.4155/FMC.13.133

1 reference

5 August 2017

1 reference