(Q34992458)

5 August 2017

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title

Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? (English)

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5 August 2017

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2

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5 August 2017

1

Gert C Scheper

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PubMed ID

12423333

5 August 2017

language of work or name

English

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publication date

1 November 2002

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5 August 2017

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5 August 2017

269

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5 August 2017

5350-5359

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5 August 2017

22

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Cleavage of polypeptide chain initiation factor eIF4GI during apoptosis in lymphoma cells: characterisation of an internal fragment generated by caspase-3-mediated cleavage

5 August 2017

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12 December 2020

Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray

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12 December 2020

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

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12 December 2020

Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo

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12 December 2020

Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells

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12 December 2020

Regulation of mammalian translation factors by nutrients

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12 December 2020

Drosophila S6 kinase: a regulator of cell size.

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12 December 2020

Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors

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12 December 2020

Regulation of translation initiation factors by signal transduction.

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12 December 2020

Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible reg

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12 December 2020

Modifications of eukaryotic initiation factor 4F (eIF4F) in adult cardiocytes by adenoviral gene transfer: differential effects on eIF4F activity and total protein synthesis rates

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12 December 2020

Murine coronavirus replication-induced p38 mitogen-activated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells

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12 December 2020

Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth

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12 December 2020

Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells

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12 December 2020

Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo

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12 December 2020

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology

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12 December 2020

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

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12 December 2020

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

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12 December 2020

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

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12 December 2020

Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta

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12 December 2020

Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies

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12 December 2020

The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways

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12 December 2020

DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling

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12 December 2020

Translation initiation factors induce DNA synthesis and transform NIH 3T3 cells

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12 December 2020

Insulin-stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway

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12 December 2020

Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F

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12 December 2020

Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells

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12 December 2020

eIF4G dramatically enhances the binding of eIF4E to the mRNA 5'-cap structure

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12 December 2020

Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo

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12 December 2020

Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.

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12 December 2020

Stabilization of eukaryotic initiation factor 4E binding to the mRNA 5'-Cap by domains of eIF4G.

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12 December 2020

Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins

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12 December 2020

Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1.

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12 December 2020

Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20.

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12 December 2020

Effect of dietary protein on translation initiation in rat skeletal muscle and liver.

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12 December 2020

Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

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12 December 2020

Prospective study of eukaryotic initiation factor 4E protein elevation and breast cancer outcome

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12 December 2020

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form

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12 December 2020

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

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12 December 2020

Effect of mRNA cap structure on eIF-4E phosphorylation and cap binding analyses using Ser209-mutated eIF-4Es.

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12 December 2020

Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state

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12 December 2020

Translation driven by an eIF4G core domain in vivo

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12 December 2020

Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise.

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12 December 2020

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

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12 December 2020

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

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12 December 2020

Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein

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12 December 2020

Cap-binding protein (eukaryotic initiation factor 4E) and 4E-inactivating protein BP-1 independently regulate cap-dependent translation

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12 December 2020

Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.

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12 December 2020

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

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12 December 2020

Specificity and mechanism of action of some commonly used protein kinase inhibitors

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12 December 2020

The emerging roles of translation factor eIF4E in the nucleus

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12 December 2020

The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth

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12 December 2020

Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure.

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12 December 2020

Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase

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12 December 2020

Isolation of translationally controlled mRNAs by differential screening.

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12 December 2020

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

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12 December 2020

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

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12 December 2020

PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.

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12 December 2020

Molecular mechanisms for the control of translation by insulin

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12 December 2020

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

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12 December 2020

Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency

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12 December 2020

pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167

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12 December 2020

In vitro synthesis, phosphorylation, and localization on 48 S initiation complexes of human protein synthesis initiation factor 4E

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12 December 2020

eIF4E expression in tumors: its possible role in progression of malignancies

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12 December 2020

Protein Phosphorylation in Translational Control

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12 December 2020

Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells

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12 December 2020

Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209

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12 December 2020

A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E

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12 December 2020

Malignant transformation by overproduction of translation initiation factor eIF4G.

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12 December 2020

Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2

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12 December 2020

The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells

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12 December 2020

Regulation of translation initiation by amino acids in eukaryotic cells.

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12 December 2020

Selective killing of cancer cells based on translational control of a suicide gene.

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12 December 2020

10.1046/J.1432-1033.2002.03291.X

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12423333