(Q34995785)

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Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms

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21 January 2020

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms (English)

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21 January 2020

Markus Morawski

2

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21 January 2020

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21 January 2020

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Maike Hartlage-Rübsamen

1

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21 January 2020

Alexander Waniek

3

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21 January 2020

Carsten Jäger

4

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21 January 2020

Ulrike Zeitschel

5

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21 January 2020

Birgit Koch

6

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21 January 2020

Stephan Schilling

8

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21 January 2020

Reinhard Schliebs

9

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21 January 2020

Hans-Ulrich Demuth

10

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21 January 2020

Steffen Rossner

11

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21 January 2020

publication date

8 February 2011

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21 January 2020

Acta Neuropathologica

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21 January 2020

121

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21 January 2020

6

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21 January 2020

705-719

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21 January 2020

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Are the dorsal and ventral hippocampus functionally distinct structures?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Classification and basic pathology of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Seeding neuritic plaques from the distance: a possible role for brainstem neurons in the development of Alzheimer's disease pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

The hippocampus and memory: insights from spatial processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

The perforant path: projections from the entorhinal cortex to the dentate gyrus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Laminating the hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Basal forebrain cholinergic immunolesion by 192IgG-saporin: evidence for a presynaptic location of subpopulations of alpha 2- and beta-adrenergic as well as 5-HT2A receptors on cortical cholinergic terminals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Noradrenaline nerve terminals in the hippocampal region of the rat and the guinea pig

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Primary structure and functional expression of a glutaminyl cyclase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Neuropathological stageing of Alzheimer-related changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Alzheimer's disease affects limbic nuclei of the thalamus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

8 July 2018

Beta-amyloid plaques: stages in life history or independent origin?

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

The laminar distribution of neuritic plaques in the fascia dentata of patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

N-terminal truncated pyroglutamyl beta amyloid peptide Abetapy3-42 shows a faster aggregation kinetics than the full-length Abeta1-42.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Extracellular amyloid formation and associated pathology in neural grafts

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

beta-amyloid is different in normal aging and in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Presenilin-1 mutations in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Selective deposition of amyloid-beta protein in the entorhinal-dentate projection of a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

The entorhinal cortex of the mouse: organization of the projection to the hippocampal formation

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0806-2

21 January 2018

Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis.

1 reference

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26 October 2018

Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098988

26 October 2018

Noradrenergic innervation of the adult rat hippocampal formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21301857

12 December 2020

based on heuristic

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Glutaminyl-cyclase expression in the bovine/porcine hypothalamus and pituitary

1 reference

https://pubmed.ncbi.nlm.nih.gov/21301857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21301857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal loss and neurofibrillary degeneration in the hippocampal cortex in late-onset sporadic Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21301857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1007/S00401-011-0806-2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21301857%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

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21 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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21 January 2020

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