(Q34998099)

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FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

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author name string

Keng G Lim

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Francesca Tonelli

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Zaiguo Li

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Xuequan Lu

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Robert Bittman

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Susan Pyne

6

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Nigel J Pyne

7

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

0 references

publication date

4 April 2011

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Europe PubMed Central

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5 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

5 August 2017

286

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

21

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

18633-18640

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Sphingosine 1-phosphate and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Antitumor activity of sphingosine kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Sphingosine kinase 1 is up-regulated in colon carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Sphingosine kinase 1 is an intracellular effector of phosphatidic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Discovery and evaluation of inhibitors of human sphingosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Relationships between inhibition constants, inhibitor concentrations for 50% inhibition and types of inhibition: new ways of analysing data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099679

8 July 2018

The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.220756

21 January 2018

Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.220756

21 January 2018

A point mutant of human sphingosine kinase 1 with increased catalytic activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.220756

21 January 2018

FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.220756

21 January 2018

Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.220756

21 January 2018

Identifiers

10.1074/JBC.M111.220756

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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