(Q34121255)

31 July 2017

1 reference

title

Sphingosine 1-phosphate and cancer. (English)

1 reference

31 July 2017

Nigel J Pyne

1

1 reference

31 July 2017

Susan Pyne

series ordinal

2

1 reference

31 July 2017

language of work or name

English

0 references

publication date

17 June 2010

1 reference

31 July 2017

Nature Reviews Cancer

1 reference

31 July 2017

10

1 reference

31 July 2017

489-503

1 reference

31 July 2017

7

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc2875

31 July 2017

0 references

cites work

Sphingosine-1-phosphate: an enigmatic signalling lipid

1 reference

Biologically active sphingolipids in cancer pathogenesis and treatment

31 March 2020

1 reference

Principles of bioactive lipid signalling: lessons from sphingolipids

31 March 2020

1 reference

An oncogenic role of sphingosine kinase

31 March 2020

1 reference

The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction?

31 March 2020

1 reference

Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients

31 March 2020

1 reference

Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue

31 March 2020

1 reference

Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival

31 March 2020

1 reference

Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines

31 March 2020

1 reference

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation

31 March 2020

1 reference

Role for sphingosine kinase 1 in colon carcinogenesis.

31 March 2020

1 reference

Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions

31 March 2020

1 reference

Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.

31 March 2020

1 reference

Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression

31 March 2020

1 reference

PAI-1 and EGFR expression in adult glioma tumors: toward a molecular prognostic classification.

31 March 2020

1 reference

EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells

31 March 2020

1 reference

S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells

31 March 2020

1 reference

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets

31 March 2020

1 reference

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

31 March 2020

1 reference

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

31 March 2020

1 reference

Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

31 March 2020

1 reference

A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC).

31 March 2020

1 reference

The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish.

31 March 2020

1 reference

The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors

31 March 2020

1 reference

Regulation and functional roles of sphingosine kinases

31 March 2020

1 reference

Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease

31 March 2020

1 reference

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

31 March 2020

1 reference

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

31 March 2020

1 reference

The mechanism of membrane targeting of human sphingosine kinase 1.

31 March 2020

1 reference

Effect of acidic phospholipids on sphingosine kinase

31 March 2020

1 reference

Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis

31 March 2020

1 reference

Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells

31 March 2020

1 reference

A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes

31 March 2020

1 reference

Sphingosine kinase 1 is an intracellular effector of phosphatidic acid

31 March 2020

1 reference

Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools

31 March 2020

1 reference

Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling

31 March 2020

1 reference

Mechanisms of PECAM-1-mediated cytoprotection and implications for cancer cell survival

31 March 2020

1 reference

Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members

31 March 2020

1 reference

Aminoacylase 1 is a sphingosine kinase 1-interacting protein

31 March 2020

1 reference

Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma.

31 March 2020

1 reference

Not just for housekeeping: protein initiation and elongation factors in cell growth and tumorigenesis

31 March 2020

1 reference

Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity

31 March 2020

1 reference

Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1

31 March 2020

1 reference

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

31 March 2020

1 reference

Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis

31 March 2020

1 reference

Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.

31 March 2020

1 reference

A lipid binding domain in sphingosine kinase 2

31 March 2020

1 reference

Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis

31 March 2020

1 reference

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin

31 March 2020

1 reference

Sphingosine kinase type 2 activation by ERK-mediated phosphorylation

31 March 2020

1 reference

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

31 March 2020

1 reference

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

31 March 2020

1 reference

Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.

31 March 2020

1 reference

Essential role for sphingosine kinases in neural and vascular development

31 March 2020

1 reference

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

31 March 2020

1 reference

Ceramide as an activator lipid of cathepsin D.

31 March 2020

1 reference

Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells

31 March 2020

1 reference

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

31 March 2020

1 reference

Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis

31 March 2020

1 reference

Sphingosine-1-phosphate mediates transcriptional regulation of key targets associated with survival, proliferation, and pluripotency in human embryonic stem cells

31 March 2020

1 reference

Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner

31 March 2020

1 reference

Bax directly induces release of cytochrome c from isolated mitochondria

31 March 2020

1 reference

Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells

31 March 2020

1 reference

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression

31 March 2020

1 reference

High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation

31 March 2020

1 reference

Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models

31 March 2020

1 reference

Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells

31 March 2020

1 reference

Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells

31 March 2020

1 reference

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

31 March 2020

1 reference

Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models.

31 March 2020

1 reference

Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation.

31 March 2020

1 reference

Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity

31 March 2020

1 reference

S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.

31 March 2020

1 reference

Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN

31 March 2020

1 reference

Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling

31 March 2020

1 reference

Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration

31 March 2020

1 reference

S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells

31 March 2020

1 reference

Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness.

31 March 2020

1 reference

Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells

31 March 2020

1 reference

The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients

31 March 2020

1 reference

Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia

31 March 2020

1 reference

Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation

31 March 2020

1 reference

Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis.

31 March 2020

1 reference

Sphingosine 1-phosphate induces EGFR expression via Akt/NF-kappaB and ERK/AP-1 pathways in rat vascular smooth muscle cells

31 March 2020

1 reference

Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells

31 March 2020

1 reference

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1

31 March 2020

1 reference

Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity

31 March 2020

1 reference

Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells

31 March 2020

1 reference

Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration

31 March 2020

1 reference

Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility

31 March 2020

1 reference

EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

31 March 2020

1 reference

S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).

31 March 2020

1 reference

Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells

31 March 2020

1 reference

Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells

31 March 2020

1 reference

Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1.

31 March 2020

1 reference

Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination

31 March 2020

1 reference

GPCR-jacking: from a new route in RTK signalling to a new concept in GPCR activation

31 March 2020

1 reference

VEGF receptor expression and signaling in human bladder tumors

31 March 2020

1 reference

Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth.

31 March 2020

1 reference

Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.

31 March 2020

1 reference

Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway.

31 March 2020

1 reference

Sliding p21-activated kinase 1 to nucleus impacts tamoxifen sensitivity.

31 March 2020

1 reference

Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival

31 March 2020

1 reference

Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state

31 March 2020

1 reference

Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers.

31 March 2020

1 reference

The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells

31 March 2020

1 reference

Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells

31 March 2020

1 reference

Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2.

31 March 2020

1 reference

Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.

31 March 2020

1 reference

Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells.

31 March 2020

1 reference

Role and regulation of autophagy in cancer

31 March 2020

1 reference

Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation

31 March 2020

1 reference

Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2

31 March 2020

1 reference

Antitumor activity of sphingosine kinase inhibitors

31 March 2020

1 reference

A novel sphingosine kinase inhibitor induces autophagy in tumor cells

31 March 2020

1 reference

S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.

31 March 2020

1 reference

Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer

31 March 2020

1 reference

A molecular signature of metastasis in primary solid tumors

31 March 2020

1 reference

Differential gene expression in ovarian carcinoma: identification of potential biomarkers

31 March 2020

1 reference

High-resolution mapping of genomic imbalance and identification of gene expression profiles associated with differential chemotherapy response in serous epithelial ovarian cancer

31 March 2020

1 reference

Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner.

31 March 2020

1 reference

Sphingosine kinase 1 is up-regulated in colon carcinogenesis

31 March 2020

1 reference

Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability

31 March 2020

1 reference

Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses

31 March 2020

1 reference

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

31 March 2020

1 reference

Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase

31 March 2020

1 reference

A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis

31 March 2020

1 reference

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies

31 March 2020

1 reference

Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents

31 March 2020

1 reference

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

31 March 2020

1 reference

Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization

31 March 2020

1 reference

The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells

31 March 2020

1 reference

Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.

31 March 2020

1 reference

Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects

31 March 2020

1 reference

NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis

31 March 2020

1 reference

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

31 March 2020

1 reference

Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts

31 March 2020

1 reference

Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases

31 March 2020

1 reference

Discovery of novel sphingosine kinase 1 inhibitors

31 March 2020

1 reference

Characterization of B-5354c, a new sphingosine kinase inhibitor, produced by a marine bacterium

31 March 2020

1 reference

S-15183a and b, New Sphingosine Kinase Inhibitors, Produced by a Fungus.

31 March 2020

1 reference

New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets

31 March 2020

1 reference

Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.

31 March 2020

1 reference

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

31 March 2020

1 reference

The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors

31 March 2020

1 reference

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

31 March 2020

1 reference

Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.

31 March 2020

1 reference

The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors

31 March 2020

1 reference

The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity

31 March 2020

1 reference

Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart

31 March 2020

1 reference

Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner

31 March 2020

1 reference

FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells

31 March 2020

1 reference

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia

31 March 2020

1 reference

A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

31 March 2020

1 reference

Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization

31 March 2020

1 reference

Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells

31 March 2020

1 reference

The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.

31 March 2020

1 reference

International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature

31 March 2020

1 reference

Feasibility of chemohyperthermia with docetaxel-embedded magnetoliposomes as minimally invasive local treatment for cancer

31 March 2020

1 reference

Molecular cloning and functional characterization of murine sphingosine kinase

31 March 2020

1 reference

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

31 March 2020

1 reference

Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines

31 March 2020

1 reference

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

31 March 2020

1 reference

Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C.

31 March 2020

1 reference

Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease

31 March 2020

1 reference

Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c.

31 March 2020

1 reference

Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1.

31 March 2020

1 reference

Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors

31 March 2020

1 reference

Sphingosine 1-phosphate analogs as receptor antagonists

31 March 2020

1 reference

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

31 March 2020

1 reference

Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation

31 March 2020

1 reference

FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling

31 March 2020

1 reference

Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment

31 March 2020

1 reference

FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation

31 March 2020

1 reference

Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases

31 March 2020

1 reference

FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.

31 March 2020

1 reference

Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma.

31 March 2020

1 reference

Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival

31 March 2020

1 reference

12 December 2020

FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.

1 reference

12 December 2020

Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes

1 reference

12 December 2020

In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells

1 reference

12 December 2020

Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells

1 reference

12 December 2020

F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete

1 reference

12 December 2020

Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat

1 reference

12 December 2020

S-15183a and b, new sphingosine kinase inhibitors, produced by a fungus

1 reference

12 December 2020

Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity.

1 reference

12 December 2020

The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor

1 reference

12 December 2020

Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice

1 reference

12 December 2020

The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients

1 reference

12 December 2020

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug

1 reference

12 December 2020

Sphingosine 1-phosphate signalling in mammalian cells

1 reference

12 December 2020

Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.

1 reference

12 December 2020

Activation of casein kinase II by sphingosine.

1 reference

12 December 2020

Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.

1 reference

12 December 2020

Discovery and evaluation of inhibitors of human sphingosine kinase

1 reference

12 December 2020

A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin

1 reference

12 December 2020

The role and clinical applications of bioactive lysolipids in ovarian cancer

1 reference

12 December 2020

Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference

1 reference

12 December 2020

Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho.

1 reference

12 December 2020

Lysophospholipids are potential biomarkers of ovarian cancer

1 reference

12 December 2020

Sphingosine kinase: biochemical and cellular regulation and role in disease

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC2875

1 reference

Dimensions Publication ID

31 July 2017

0 references

1 reference