(Q36715339)

15 August 2017

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title

Regulation and functional roles of sphingosine kinases (English)

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15 August 2017

Regina Alemany

1

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15 August 2017

Chris J van Koppen

2

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15 August 2017

Kerstin Danneberg

3

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15 August 2017

Michael Ter Braak

4

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15 August 2017

Dagmar Meyer Zu Heringdorf

5

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15 August 2017

23 January 2007

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Naunyn-Schmiedeberg's Archives of Pharmacology

15 August 2017

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15 August 2017

374

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15 August 2017

5-6

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15 August 2017

413-428

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https://scigraph.springernature.com/pub.10.1007/s00210-007-0132-3

15 August 2017

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cites work

Sphingosine-1-phosphate receptors and the development of the vascular system

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Subcellular study of sphingoid base phosphorylation in rat tissues: evidence for multiple sphingosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Sphingolipids and the balancing of immune cell function: lessons from the mast cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Sphingolipid-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Sphingosine kinase: biochemical and cellular regulation and role in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Positive modulation of IL-12 signaling by sphingosine kinase 2 associating with the IL-12 receptor beta 1 cytoplasmic region

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-007-0132-3

Sphingosine kinase transmits estrogen signaling in human breast cancer cells.

21 January 2018

1 reference

12 December 2020

Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism

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12 December 2020

Lysophospholipid receptors: signaling and biology

1 reference

12 December 2020

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

1 reference

12 December 2020

The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane

1 reference

12 December 2020

Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity

1 reference

12 December 2020

The ins and outs of sphingolipid synthesis

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12 December 2020

Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis

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12 December 2020

CpG island of rat sphingosine kinase-1 gene: tissue-dependent DNA methylation status and multiple alternative first exons

1 reference

12 December 2020

Functional characterization of human sphingosine kinase-1

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12 December 2020

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

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12 December 2020

Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.

1 reference

12 December 2020

Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine

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12 December 2020

Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease

1 reference

12 December 2020

Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.

1 reference

12 December 2020

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

1 reference

12 December 2020

Molecular cloning and functional characterization of murine sphingosine kinase

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12 December 2020

Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.

1 reference

12 December 2020

International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature

1 reference

12 December 2020

Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol.

1 reference

12 December 2020

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

1 reference

12 December 2020

Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.

1 reference

12 December 2020

Antitumor activity of sphingosine kinase inhibitors

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12 December 2020

Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models

1 reference

12 December 2020

A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells

1 reference

12 December 2020

Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release

1 reference

12 December 2020

Essential role for sphingosine kinases in neural and vascular development

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12 December 2020

Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis

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12 December 2020

Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells

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12 December 2020

Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis

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12 December 2020

Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.

1 reference

12 December 2020

The mechanism of membrane targeting of human sphingosine kinase 1.

1 reference

12 December 2020

Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase

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12 December 2020

Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases

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12 December 2020

Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation.

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12 December 2020

Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient

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12 December 2020

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

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12 December 2020

Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase

1 reference

12 December 2020

The role of sphingosine-1-phosphate in smooth muscle contraction

1 reference

12 December 2020

Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation.

1 reference

12 December 2020

Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes

1 reference

12 December 2020

Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium

1 reference

12 December 2020

IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses

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12 December 2020

Tumor necrosis factor- induces adhesion molecule expression through the sphingosine kinase pathway

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12 December 2020

Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice

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12 December 2020

Sphingosine kinase signalling in immune cells

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12 December 2020

Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling

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12 December 2020

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate

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12 December 2020

Biologically active sphingolipids in cancer pathogenesis and treatment

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12 December 2020

Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1.

1 reference

12 December 2020

Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival.

1 reference

12 December 2020

Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1.

1 reference

12 December 2020

Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner

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12 December 2020

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

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12 December 2020

Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension

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12 December 2020

Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2

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12 December 2020

Sphingosine-1-phosphate: an enigmatic signalling lipid

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12 December 2020

Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts

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12 December 2020

Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

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12 December 2020

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

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12 December 2020

Discovery and evaluation of inhibitors of human sphingosine kinase

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12 December 2020

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

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12 December 2020

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation

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12 December 2020

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

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12 December 2020

Point-counterpoint of sphingosine 1-phosphate metabolism

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12 December 2020

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

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12 December 2020

Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries

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12 December 2020

Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability

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12 December 2020

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

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12 December 2020

Effect of acidic phospholipids on sphingosine kinase

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12 December 2020

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution

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12 December 2020

Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation

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12 December 2020

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

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12 December 2020

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

1 reference

12 December 2020

Lysophospholipid receptor-dependent and -independent calcium signaling.

1 reference

12 December 2020

Identification of functional nuclear export sequences in human sphingosine kinase 1

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12 December 2020

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.

1 reference

12 December 2020

Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility

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12 December 2020

Sphingosine kinase-dependent activation of endothelial nitric oxide synthase by angiotensin II.

1 reference

12 December 2020

Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis

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12 December 2020

Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis

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12 December 2020

The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function

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12 December 2020

Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization

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12 December 2020

Sphingosine kinase 1 is an intracellular effector of phosphatidic acid

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12 December 2020

Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors

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12 December 2020

Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells

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12 December 2020

Sphingosine kinase 1 is up-regulated in colon carcinogenesis

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12 December 2020

Lysophospholipid G protein-coupled receptors

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12 December 2020

The nucleotide-binding site of human sphingosine kinase 1

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12 December 2020

Purification and characterization of rat kidney sphingosine kinase

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12 December 2020

Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition

1 reference

12 December 2020

Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells

1 reference

12 December 2020

Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation

1 reference

12 December 2020

VEGF receptor expression and signaling in human bladder tumors

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12 December 2020

An oncogenic role of sphingosine kinase

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12 December 2020

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients

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12 December 2020

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

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12 December 2020

FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.

1 reference

12 December 2020

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

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12 December 2020

1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate

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12 December 2020

Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate

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12 December 2020

Physiological and pathological actions of sphingosine 1-phosphate.

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12 December 2020

Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites

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12 December 2020

Enzymes of sphingolipid metabolism: from modular to integrative signaling

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12 December 2020

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

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12 December 2020

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1

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12 December 2020

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

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12 December 2020

Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer

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12 December 2020

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

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12 December 2020

A point mutant of human sphingosine kinase 1 with increased catalytic activity

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12 December 2020

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

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12 December 2020

PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

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12 December 2020

Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.

1 reference

12 December 2020

Lipid phosphate phosphatases and lipid phosphate signalling

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12 December 2020

Role of sphingosine kinase 2 in cell migration toward epidermal growth factor

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12 December 2020

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

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12 December 2020

Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase

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12 December 2020

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

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12 December 2020

10.1007/S00210-007-0132-3

Identifiers

DOI

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15 August 2017

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