(Q35045183)

6 August 2017

title

A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells (English)

1 reference

6 August 2017

1 reference

proto-oncogene protein

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12711631

27 December 2023

1 reference

https://api.crossref.org/works/10.1038/SJ.BJP.0705182

27 December 2023

author name string

Yumiko Matsuoka

1

1 reference

6 August 2017

Yukitoshi Nagahara

2

1 reference

6 August 2017

Masahiko Ikekita

3

1 reference

6 August 2017

Takahisa Shinomiya

4

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 April 2003

1 reference

full work available at URL

6 August 2017

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0705182

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12711631

https://europepmc.org/articles/PMC1573783

27 December 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12711631

https://europepmc.org/articles/PMC1573783?pdf=render

27 December 2023

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12711631

https://doi.org/10.1038/sj.bjp.0705182

27 December 2023

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12711631

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Fsj.bjp.0705182

27 December 2023

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1038/SJ.BJP.0705182

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1038/sj.bjp.0705182

27 December 2023

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1038/SJ.BJP.0705182

British Journal of Pharmacology

27 December 2023

published in

1 reference

6 August 2017

volume

138

1 reference

6 August 2017

issue

7

1 reference

6 August 2017

page(s)

1303-1312

1 reference

Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity

6 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

PTEN controls tumor-induced angiogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

PTEN: life as a tumor suppressor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Cellular function of p70S6K: a role in regulating cell motility

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

PTEN, a unique tumor suppressor gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Protein kinases as mediators of phosphoinositide 3-kinase signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

The PI3K-PDK1 connection: more than just a road to PKB

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Protein phosphorylation and protein phosphatases. De Panne, Belgium, September 19-24, 1999.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Phosphorylation and activation of p70s6k by PDK1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Akt signaling: linking membrane events to life and death decisions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720.

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0705182

p27Kip1 is required for PTEN-induced G1 growth arrest.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573783

Evidence that FTY720 induces T cell apoptosis in vivo

25 October 2018

1 reference

12 December 2020

Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria

1 reference

12 December 2020

Cyclin transcription: Timing is everything

1 reference

12 December 2020

Purification and properties of a distinct protamine kinase from the cytosol of bovine kidney cortex

1 reference

12 December 2020

An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60

1 reference

12 December 2020

Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway

1 reference

12 December 2020

Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas

1 reference

12 December 2020

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues

1 reference

12 December 2020

A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation

1 reference

12 December 2020

Potent immunosuppressants, 2-alkyl-2-aminopropane-1,3-diols

1 reference

12 December 2020

The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720

1 reference

12 December 2020

A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes

1 reference

12 December 2020

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

1 reference

12 December 2020

Identifiers

DOI

1 reference

6 August 2017

1 reference

6 August 2017

1 reference