(Q34999097)

English

Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

desensitization

1 reference

based on heuristic

inferred from title

author name string

Markus Rey

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Patrick Hess

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Martine Clozel

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Stéphane Delahaye

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

John Gatfield

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Oliver Nayler

6

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Beat Steiner

7

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

0 references

publication date

12 September 2013

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

e74285

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

copyright license

Creative Commons Attribution 4.0 International

12 September 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, in the first-in-human study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

Pharmacology of the sphingosine-1-phosphate signalling system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

β-Arrestin-mediated receptor trafficking and signal transduction

1 reference

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8 July 2018

The utility of the small rodent electrocardiogram in toxicology

1 reference

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8 July 2018

Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls

1 reference

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8 July 2018

2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

Sphingosine 1-phosphate receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

Biological effects of lysophospholipids

1 reference

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8 July 2018

Regulation of immunity by lysosphingolipids and their G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

G-protein mediated gating of inward-rectifier K+ channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

8 July 2018

The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074285

21 January 2018

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074285

21 January 2018

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074285

21 January 2018

Practical application of guinea pig telemetry system for QT evaluation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074285

21 January 2018

Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs: a model for screening QT interval prolongation effects

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074285

21 January 2018

Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074285

21 January 2018

Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074285

21 January 2018

Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074285

21 January 2018

The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

26 October 2018

First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771878

26 October 2018

Differences in rapid desensitization of 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptor-mediated phospholipase C activation

1 reference

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26 October 2018

Atrioventricular conduction disturbances during hypoxia. Possible role of adenosine in rabbit and guinea pig heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/24069292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0074285

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

2013PLoSO...874285R

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

0 references

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