(Q34999485)

5 August 2017

1 reference

title

Artemisinin: mechanisms of action, resistance and toxicity (English)

1 reference

5 August 2017

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1

Steven R Meshnick

1 reference

5 August 2017

1 December 2002

1 reference

International Journal for Parasitology

5 August 2017

1 reference

5 August 2017

32

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5 August 2017

13

1 reference

5 August 2017

1655-1660

1 reference

Reaction between ferriprotoporphyrin IX and the antimalarial endoperoxide artesunate gives an intermediate species with enhanced redox catalytic activity

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Effects of antimalarials and protease inhibitors on plasmodial hemozoin production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Reaction of antimalarial endoperoxides with specific parasite proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Artemisinin enhances heme-catalysed oxidation of lipid membranes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Immunoprecipitation of [(3)H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

The Plasmodium falciparum translationally controlled tumor protein: subcellular localization and calcium binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Arteether, a new antimalarial drug: synthesis and antimalarial properties

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

EPR evidence for the involvement of free radicals in the iron-catalysed decomposition of qinghaosu (artemisinin) and some derivatives; antimalarial action of some polycyclic endoperoxides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Artemisinin (qinghaosu)--a new gametocytocidal drug for malaria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

The toxicity of artemisinin and related compounds on neuronal and glial cells in culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Stage specific actions of antimalarial drugs on Plasmodium falciparum in culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with Formation of N-oxides — a chemical model for antimalarial mode of action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

The interaction of artemisinin with malarial hemozoin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Induction and isolation of artemisinine-resistant mutants of Plasmodium falciparum.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Qinghaosu-induced changes in the morphology of Plasmodium inui.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Ferryl-oxo heme intermediate in the antimalarial mode of action of artemisinin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Qinghaosu, dietary vitamin E, selenium, and cod-liver oil: effect on the susceptibility of mice to the malarial parasite Plasmodium yoelii

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Two patients with falciparum malaria and poor in vivo responses to artesunate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Morphologic effects of artemisinin in Plasmodium falciparum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Artemisinin derivatives in the treatment of falciparum malaria in pregnancy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Artemisinin derivatives for treating uncomplicated malaria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Ataxia and slurred speech after artesunate treatment for falciparum malaria.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Studies of the neurotoxicity of oral artemisinin derivatives in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Further Evidence Supporting the Importance of and the Restrictions on a Carbon-Centered Radical for High Antimalarial Activity of 1,2,4-Trioxanes Like Artemisinin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Effects of artemisinin derivatives on malaria transmissibility.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Hemoglobin catabolism and iron utilization by malaria parasites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Apparent drug failure following artesunate treatment of Plasmodium falciparum malaria in Freetown, Sierra Leone: four case reports

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Neurotoxic mode of action of artemisinin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Thalassaemia trait, red blood cell age and oxidant stress: effects on Plasmodium falciparum growth and sensitivity to artemisinin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Molecular modeling studies of the artemisinin (qinghaosu)-hemin interaction: docking between the antimalarial agent and its putative receptor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

The potential of artemether for the control of schistosomiasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Artemether-lumefantrine for the treatment of multidrug-resistant falciparum malaria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Enhancement of hemin-induced membrane damage by artemisinin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Antimalarial drug resistance and combination chemotherapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Assessment of the pharmacodynamic properties of antimalarial drugs in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Atovaquone in the treatment of Babesia microti infections in hamsters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarials

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Comparison of 3D quantitative structure-activity relationship methods: analysis of the in vitro antimalarial activity of 154 artemisinin analogues by hypothetical active-site lattice and comparative molecular field analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Alkylation of human albumin by the antimalarial artemisinin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Hemin-catalyzed decomposition of artemisinin (qinghaosu)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

Assessment of the neurotoxicity of parenteral artemisinin derivatives in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

inferred from DOI database lookup

7 January 2021

based on heuristic

The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenes

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2802%2900194-7

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0020-7519(02)00194-7

1 reference

5 August 2017

1 reference

PubMed ID

12435450