(Q35002458)

English

The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5 (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

author name string

Fang Xie

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Xin Zhou

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Mary Beth Genter

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Melissa Behr

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Jun Gu

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Xinxin Ding

6

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

publication date

17 March 2011

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

39

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

947-951

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation

1 reference

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8 July 2018

Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

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Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism

1 reference

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8 July 2018

Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

8 July 2018

Regulation of cytochrome P450 gene expression in the olfactory mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

8 July 2018

Methimazole-induced damage in the olfactory mucosa: effects on ultrastructure and glutathione levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

8 July 2018

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

8 July 2018

Methimazole-induced hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

8 July 2018

Extrathyroidal actions of antithyroid thionamides

1 reference

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8 July 2018

Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

8 July 2018

Age-related susceptibility to 3,3'-iminodipropionitrile-induced olfactory mucosal damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

8 July 2018

Methimazole toxicity in rodents: covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

8 July 2018

Metabolism of methimazole by rat liver cytochrome P-450-containing monoxygenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

8 July 2018

Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

26 October 2018

In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

26 October 2018

Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

26 October 2018

Bioavailability of transdermal methimazole in a pluronic lecithin organogel (PLO) in healthy cats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

26 October 2018

Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

26 October 2018

Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100904

26 October 2018

Histopathologic examination of the rat nasal cavity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21415250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific expression of flavin-containing monooxygenase (FMO) forms 1 and 2 in the rabbit

1 reference

https://pubmed.ncbi.nlm.nih.gov/21415250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism-dependent toxicity of methimazole in the olfactory nasal mucosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/21415250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21415250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione

1 reference

https://pubmed.ncbi.nlm.nih.gov/21415250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Methimazole and propylthiouracil induced acute toxic hepatitis]

1 reference

https://pubmed.ncbi.nlm.nih.gov/21415250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.110.037895

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

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